2014 Publications

 

Zhang Z, Shirarsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer RG, Ramnath N, Nagrath S. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget. 2014 1 Dec. PubMed PMID: 25474037.

Deng L, Shang L, Bai S, Chen J, He X, Trevino RM, Chen S, Li X, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginistier C, Ibarra I, Ke J, Luther TK, Clouthier SG, Xu L, Shan G, Song E, Yao H, Hannon GJ, Weiss SJ, Wicha MS, Liu S. microRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Res. 2014 Sep 12. PubMed PMID: 25217527.

Krishnamurthy S, Warner KA, Dong Z, Imai A, Nor C, Ward BB, Helman JI, Taichman RS, Bellile EL, McCauley LK, Polverini PJ, Prince ME, Wicha MS, Nor JE. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells. 2014 Jul 30. PubMed PMID: 25078284.

Murlidhar V, Zeinali M, Grabauskiene S, Ghannad-Rezaie M, Wicha MS, Simeone DM, Ramnath N, Reddy RM, Nagrath S. A radial flow microfluidic device for ultra-high throughput affinity-based isolation of circulating tumor cells. Small. 2014 Jul 29. PubMed PMID: 25074448.

Lombardi S, Honeth G, Ginestier C, Shinomiya Y, Marlow R, Buchupalli B, Gazinska P, Brown J, Catchpole S, Liu S, Barkan A, Wicha M, Purushotham A, Burchell J, Pinder S, Dontu G. Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells. Stem Cell Reports. 2014 June 3; 2(6):780-93. PubMed PMID: 24936466. PMCID: PMC4050343

Kim G, Ouzounova M, Quraishi AA, Davis A, Tawakkol N, Clouthier SG, Malik F, Paulson AK, D'Angelo RC, Korkaya S, Baker TL, Esen ES, Prat A, Liu S, Kleer CG, Thomas DG, Wicha MS, Korkaya H. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. Oncogene. 2014 Feb 17. PubMed PMID: 24531711.

Liu S, Yin F, Zhang J, Wicha MS, Chang AE, Fan W, Chen L, Fan M, Li Q. Regulatory roles of miRNA in the human neural stem cell transformation to glioma stem cells. J Cell Biochem. 2014 Feb 12. PubMed PMID: 24519663.

Fearon ER, Wicha MS. KRAS and cancer stem cells in APC-mutant colorectal cancer. J Natl Cancer Inst. 2014 Feb 1; 106(2). PubMed PMID: 24491303.

Wicha MS. Targeting self-renewal, an Achilles' heel of cancer stem cells. Nat Med. 2014 Jan 7;20(1): 14-5. PubMed PMID 24398956.

Li Q, Lu L, Tao H, Xue C, Teitz-Tennenbaum S, Owen JH, Moyer JS, Prince ME, Chang AE, Wicha MS. Generation of a novel dendritic-cell vaccine using melanoma and squamous cancer stem cells. J Vis Exp. 2014 Jan 6; (83). PubMed PMID: 24430104. PubMed Central PMCID: PMC4063547

Wang SH, Lu L, Fan Y, Wicha MS, Cao Z, Chang AE, Xia J, Baker JR Jr., Li, Q. Characterization of a novel transgenic mouse tumor model for targeting HER2+ cancer stem cells. Int J Biol Sci. 10(1): 25-32. PubMed PMID: 24391448

2013 Publications

Liu, S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, Martin-Trevino R, Shang L, McDermott SP, Landis MD, Hong S, Adams A, D'Angelo R, Ginestier C, Charafe-Jauffret E, Clouthier SG, Birnbaum D, Wong ST, Zhan M, Chang JC, Wicha MS. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports 2013 Dec 27; 2(1): 78-91. PubMed PMID: 24511467.

Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao C, Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J. Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24- Subpopulations of Breast Cancer Cells.
PLoS One. 2013 Dec 23;8(12):e82821. PubMed PMID: 24376586

Conley SJ, Wicha MS. Breast Cancer Stem Cells: From Theory to Therapy. In: Sell S, editor. Stem Cells Handbook. Springer New York; 2013 p. 477–89.

Huang J, Li C, Wang Y, Lv H, Guo Y, Dai H, et al. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin Immunol. 2013 Oct;149(1):156–68. PubMed PMID: 23994769.

Yoon HJ, Kim TH, Zhang Z, Azizi E, Pham TM, Paoletti C, Lin J, Ramnath N, Wicha MS, Hayes DF, Simeone DM, Nagrath S. Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol. 2013 Sep 29. PubMed PMID: 24077027

Luo M, Zhao X, Chen, S, Liu S, Wicha MS, Guan JL. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Research. 2013; 73(17): 5591-602. PubMed PMID: 23832665.

Vu-Phan D, Grachtchouk V, Yu J, Colby LA, Wicha MS, Koenig RJ. The thyroid cancer PAX9-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype. Endocrine-Related Cancer. 2013; 20(5), 725-739. PubMed PMID: 24025583.

Cui TX, Kryczek I, Zhao L, Zhao E, Kuick R, Roh MH, et al. Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2. Immunity. 2013 Sep 4. PubMed PMID: 24012420.

Korkaya H, Wicha MS. HER2 and breast cancer stem cells: More than meets the eye. Cancer Res. 2013 Jun 15;73(12):3489090. PubMed PMID: 23740771.

Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res. 2013 Feb 26. PubMed PMID: 23444212.

Ithimakin S, Day KC, Malik F, Zen Q, Dawsey SJ, Bersano-Begey TF, Quraishi AA, Ignatoski KW, Daignault S, Davis A, Hall CL, Palanisamy N, Heath AN, Tawakkol N, Luther TK, Clouthier SG, Chadwick WA, Day ML, Kleer CG, Thomas DG, Hayes DF, Korkaya H, Wicha MS. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res. 2013 Feb 26. PubMed PMID: 23442322.

Wicha MS. B4 androgen ablation: Attacking the prostate cancer stem cell. J Clin. Invest. 2013 Jan 25: 1-3. PubMed PMID: 23348735.

Schott AF, Landis M, Dontu G, Griffith KA, Layman RM, Krop I, Paskett LA, Wong H, Drobolecki LE, Froehlich AM, Paranilam J, Hayes DF, Wicha MS, Chang JC. Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin. Cancer Res. 2013 Jan 22. PubMed PMID: 23340294.

Azizi E, Wicha MS. Cancer Stem Cells--The Evidence Accumulates. Clin. Chem. 2013 Jan. PubMed PMID: 23143328.

2012 Publications

Wicha MS, Korkaya H. Breast Cancer Stem Cells: We’ve got them surrounded. Clin. Cancer Res. 2012 Dec 18. PubMed PMID: 23251003.

Teitz-Tennenbaum S, Wicha MS, Chang AE, Li Q. Targeting cancer stem cells via dendritic-cell vaccination. Oncoimmunology. 2012 Nov 1;1(8):1401–3. PubMed PMID: 23243607.

Wicha MS. Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame? Breast Cancer Res. 2012 Nov 15;14(6):114. PubMed PMID: 23153392.

Duru N, Fan M, Candas D, Menaa C, Liu H-C, Nantajit D, et al. HER2-associated radiation resistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin. Cancer Res. 2012 Oct 22. PubMed PMID: 23091114.

Petrillo LA, Wolf DM, Kapoun AM, Wang NJ, Barczak A, Xiao Y, Korkaya H, Baehner F, Lewicki J, Wicha M, Park JW, Spellman PT, Gray JW, Van’t Veer L, Esserman LJ. Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors. Breast Cancer Res. Treat. 2012 Oct;135(3):913–922. PubMed PMID: 22941572.

Schwartz T, Stark A, Pang J, Awuah B, Kleer CG, Quayson S, Kingman S, Aitpillah F, Abantanga F, Jiagge E, Oppong JK, Osei-Bonsu E, Martin I, Yan X, Toy K, Adjei E, Wicha M, Newman LA. Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women. Cancer 2012 Aug. PubMed PMID: 22930220.

Malik F, Korkaya H, Clouthier SG, Wicha MS. Breast cancer heterogeneity: Need to review current treatment strategies. Curr Breast Cancer Rep. 2012 Aug, 4(4): 225-231.

Malik F, Korkaya H, Clouthier SG, Wicha MS. Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer. Cell Cycle 2012 Aug;11(15):2780–2781. PubMed PMID: 22833047.

Korkaya H, Kim G-I, Davis A, Malik F, Henry NL, Ithimakin S, Quraishi AA, Tawakkol N, D’Angelo R, Paulson AK, Chung S, Luther T, Paholak HJ, Liu S, Hassan KA, Zen Q, Clouthier SG, Wicha MS. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.Molecular Cell 2012 Jul 19. PubMed PMID: 22819326.

Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, McDermott SP, Shang L, Ke J, Ou SJ, Heath A, Zhang KJ, Korkaya H, Clouthier SG, Charafe-Jauffret E, Birnbaum D, Hannon GJ, Wicha MS. MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet. 2012 Jun 7;8(6):e1002751. PubMed PMID: 22685420.

Wicha MS. PSA lo and behold: Prostate cancer stem cells. Cell Stem Cell. 2012 May 4;10(5):482–3. PubMed PMID: 22560068.

Liu S, Korkaya H, Wicha MS. Are cancer stem cells ready for prime time? The Scientist, 2012 Apr.  Available from: http://the-scientist.com/2012/04/01/are-cancer-stem-cells-ready-for-prime-time/

Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince MEP, Xu Y, Zhang X-L, Huang S, Chang AE, Li Q. Cancer stem cell vaccination confers significant antitumor immunity. Cancer Research 2012 Apr;72(7):1853–1864. PubMed PMID: 22473314

Conley SJ, Wicha MS. Reply to Nugue and Wion: Targeting cancer stem cells’ hypoxic core. PNAS. 2012 Apr 17;109(16):E915. doi: 10.1073/pnas.1203321109

Conley SJ, Wicha MS. Antiangiogenic agents: Fueling cancer’s hypoxic roots. Cell Cycle 2012 Apr;11(7). PubMed PMID: 22421155

Liu S, Clouthier SG, Wicha MS. Role of microRNAs in the regulation of breast cancer stem cells. Journal of Mammary Gland Biology and Neoplasia; 2012 Feb. PubMed PMID: 22331423.

Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, Clouthier SG, Wicha MS. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proceedings of the National Academy of Sciences of the United States of America; 2012 Jan. PubMed PMID: 22308314.

2011 Publications

Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J. Clin. Invest. 2011 Oct;121(10):3804–3809. PubMed PMID: 21965337. PubMed Central PMCID: 3223613.

Zielske SP, Spalding AC, Wicha MS, Lawrence TS. Ablation of breast cancer stem cells with radiation. Transl Oncol 2011 Aug;4(4):227-233. PubMed PMID: 21804918. PubMed Central PMCID: PMC3140010.

Korkaya H, Wicha MS. Inflammation and autophagy conspire to promote tumor growth. Cell Cycle 2011 Aug;10(16):2623. PubMed PMID: 21829104.

Korkaya H, Liu S, Wicha MS. Regulation of cancer stem cells by cytokine networks: Attacking cancers inflammatory roots. Clin Cancer Res 2011 Jun. PubMed PMID: 21685479.

Henry NL, Banerjee M, Wicha M, Van Poznak C, Smerage JB, Schott AF, Griggs JJ, Hayes DF. Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms. Cancer 2011 Jun. PubMed PMID: 21692065.

Reddy RM, Kakarala M, Wicha MS. Clinical trial design for testing the stem cell model for the prevention and treatment of cancer. Cancers (Basel). 2011;3(2):2696–708. PubMed PMID: 24212828

Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R, Wicha MS, Ethier SP, Yang Z-Q. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene 2011 June 13. PubMed PMID: 21666724.

Silva IA, Bai S, McLean K, Yang K, Griffith KA, Dafydd T, Ginestier C, Johnston C, Kueck A, Reynolds K, Wicha MS, Buckanovich RJ. Aldehyde dehydrogenase and CD133 define angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res 2011 Apr. PubMed PMID: 21498635. PubMed Central PMCID: PMC3107359.

Kryczek I, Liu S, Roh M, Vatan L, Szeliga W, Wei S, Banerjee M, Mao Y, Kotarski J, Wicha MS, Liu R, Zou W. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer 2011 Feb. PubMed PMID: 21480217. PubMed Central PMCID: PMC3164893.

Wicha MS, Hayes DF. Circulating tumor cells: Not all detected cells are bad and not all bad cells are detected. J Clin Oncol 2011 Mar. PubMed PMID: 21422428.   

Li Y, Wicha MS, Schwartz SJ, Sun D. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem 2011 Feb. PubMed PMID: 21295962.

Wicha MS. Stemming a tumor with a little miR. Nat. Med 2011 Feb;17(2):162-164.  PubMed PMID: 21297608.

Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, Korkaya H, Heath A, Dutcher J, Kleer CG, Jung Y, Dontu G, Taichman R, Wicha MS. Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Res 2011 Jan;71(2):614-624.  PubMed PMID: 21224357. PubMed Central PMCID: PMC3100554.

2010 Publications

Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE. Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 2010 Dec;70(23):9969-9978. PubMed PMID: 21098716. PubMed Central PMCID: PMC3058885.

D'Angelo RC, Wicha MS. Stem cells in normal development and cancer. Prog Mol Biol Transl Sci 2010;95:113-158. PubMed PMID: 21075331.

Stark A, Kleer CG, Martin I, Awuah B, Nsiah-Asare A, Takyi V, Braman M, Quayson SE, Zarbo R, Wicha M, Newman L. African ancestry and higher prevalence of triple-negative breast cancer: findings from an international study. Cancer 2010 Nov;116(21):4926-4932. PubMed PMID: 20629078. PubMed Central PMCID: PMC3138711.

McDermott SP, Wicha MS. Targeting breast cancer stem cells. Mol Oncol. 2010 Oct;4(5):404-19. Epub 2010 Jun 17. PubMed PMID: 20599450. PubMed Central PMCID: PMC3023958.

McDermott SP, Wicha MS. Breast tumors: of mice and women. Breast Cancer Res. 2010;12(3):108. Epub 2010 May 27. PubMed PMID: 20550730; PubMed Central PMCID: PMC2917013.

Liu S, Wicha MS. Targeting breast cancer stem cells. J Clin Oncol. 2010 Sep 1;28(25):4006-12. Epub 2010 May 24. Review. PubMed PMID: 20498387.

Korkaya H, Wicha MS. Cancer stem cells: nature versus nurture. Nat Cell Biol. 2010 May;12(5):419-21. Epub 2010 Apr 25. PubMed PMID: 20418873.

Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res. 2010 May 1;16(9):2580-90. Epub 2010 Apr 13. PubMed PMID: 20388854; PubMed Central PMCID: PMC2862133.

Clay MR, Tabor M, Owen JH, Carey TE, Bradford CR, Wolf GT, Wicha MS, Prince ME. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck. 2010 Sep;32(9):1195-201. PubMed PMID: 20073073. PubMed Central PMCID: PMC2991066.

Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest. 2010 Feb 1;120(2):485-97. Epub 2010 Jan 4. PubMed PMID: 20051626; PubMed Central PMCID: PMC2810075.

Iniesta MD, Chien J, Wicha M, Merajver SD. One-hit effects and cancer. Cancer Prev Res (Phila) 2010 Jan;3(1):12-15. PubMed PMID: 20051368.

Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, Esterni B, Houvenaeghel G, Extra JM, Bertucci F, Jacquemier J, Xerri L, Dontu G, Stassi G, Xiao Y, Barsky SH, Birnbaum D, Viens P, Wicha MS. Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res. 2010 Jan 1;16(1):45-55. Epub 2009 Dec 22. PubMed PMID: 20028757; PubMed Central PMCID: PMC2874875.

Kakarala M, Brenner DE, Korkaya H, Cheng C, Tazi K, Ginestier C, Liu S, Dontu G, Wicha MS. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat. 2010 Aug;122(3):777-85. Epub 2009 Nov 7. PubMed PMID: 19898931. PubMed Central PMCID: PMC3039120.

Publication archives (2000 - 2009)

Book chapters

AACR abstracts (2006 - 2014)