2018 Publications

Colacino JA, Azizi E, Brooks MD, Harouaka R, Fouladdel S, McDermott S, Lee M, Hill D, Madden J, Boerner J, Cote ML, Sartor MA, Rozek LS, Wicha MS; Heterogeneity of human breast stem and progenitor cells as revealed by transcriptional profiling. Stem Cell Reports, 2018 (Publication in Process)

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouilette P, Hardt O, Chin, AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai Y, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson L, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA; Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma Cells. Development (Publication in Process)

Sehl ME, Wicha MS; (2018) Modeling of Interactions between Cancer Stem Cells and their Microenvironment: Predicting Clinical Response. In: von Stechow L. (eds) Cancer Systems Biology, vol 1711. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7493-1_16. PMID:29344897

Lin H, Hurt EM, Zhao L, Szeliga W, Harms P, Vats P, Lao C, Wicha MS, Mandai M, Zou W, Wei S, Green MD, Vatan L, Herbst R, Fecher L, Chinnaiyan AM, Lawrence T, Hamanishi J, Kryczek I; Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression. Journal of Clinical Investigation, January 2018. doi: 10.1172/JCI96113

2017 Publications

Azizi E, Granger J, Harouaka R, Luther T, Wicha MS, Stem Cells in Breast Development and Cancer; The Breast (Fifth Edition) 5 September 2017 (online); DOI: 10.1016/B978-0-323-35955-9.00023-4

Ronquist S, Patterson G, Muir LA, Lindsly S, Chen H, Brown M, Wicha MS, Bloch A, Brockett R, Rajapakse I; Algorithm for cellular reprogramming; Proceedings of the National Academy of Sciences; 2017 November 7, vol. 114 no. 46; doi: 10.1073/pnas.1712350114

Halperin RF, Carpten JD, Manojlovic Z, Aldrich J, Keats J, Byron S, Liang WS, Russell M, Enriquez D, Claasen A, Cherni I, Awuah B, Oppong J, Wicha MS, Newman LA, Jaigge E, Kim S, Craig DW. A method to reduce ancestry related germline false positives in tumor only somatic variant calling. BMC Med Genomics. 2017 Oct 19;10(1):61. doi: 10.1186/s12920-017-0296-8. PMID: 29052513 PMIC: PMC5649057

Lin E*, Rivera-Baez L*, Fouladdel, S*, Yoon H, Guthrie S, Wieger J, Deol Y, Keller E, Sahai B, Simeone D, Burness ML, Azizi E, Wicha M, Nagrath S; High Throughput Microfluidic Labyrinth for the Label Free Isolation of CTCs for Single Cell Gene Expression Profiling; Cell Systems, 2017 September 20; DOI:10.1016/j.cels.2017.08.12  PMID: 28941584 *these authors contributed equally

Wang D, Zu J, Liu B, He X, Zhou L, Hu X, Qiao F, Zhang, A, Xu X, Zhang H, Wicha M, Zhang L, Shao Z, Liu S, IL6 blockade potentiates the anti-tumor effects of y–secretase inhibitors in Notch3-expressing breast cancer; Cell Death and Differentiation, 13 October 2017 DOI: 10.1038/cdd.2017.162. PMID: 29027990

Jiagge EM, Jibril A, Divine G, Gyan KK, Bensenhaver JM, Oppong JK, Awuah B, Adjei E, Merajver S, Wicha M, Newman LA, Beyond triple-negative breast cancer and African ancestry: Tumor phenotypes among internationally diverse patient populations; Journal of Clinical Oncology 35, no.15_suppl (May 2017) 1101-1101; DOI:10.1200/JCO.2017.35.15

Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhang Z, Nor F, Wagner VP, Vargas PA, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, Nor JE, 5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Aquamous Cell Carcinoma; Clinical Cancer Research 2017 May 15;23((10):2516-2527. doi: 10.1158/1078-0432.CCR-16-1834. Epub 2066 Oct 25. PMID: 27780858

Zhang XF, Weng DSH, Pan K, Zhou ZQ, Pan QZ, Zhao JJ, Tang Y, Jiang SS, Chen CL, Li YQ, Zhang HX, Chang AE, Wicha MS, Zeng YX, Li Q, Xia JC, Dendritic-cell-based immunotherapy evokes potent anti-tumor immune responses in CD105+ human renal cancer stem cells; Molecular Carcinogenesis – 16 June 2017 doi/10.1002/mc.22697  

Nagrath S, Murlidhar V, Reddy R, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, Zhang Z, Lin J, Chang AC, Carrott PW Jr, Lynch WR, Orringer MB, Kumar-Sinha C, Palanisamy N, Beer DG, Wicha MS, Ramnath N, Azizi E, Poor Prognosis Indicated by Venout Circulating Tumor Cell Clusters in Early Stage Lung Cancer; Cancer Research - DOI: 10:1158/0008-5472.CAN-16-2072; 17 July 2017

Schott AF, Goldstein L, Cristofanilli M, Wicha MS, Phase 1b pilot study to evaluate reparixin in combination with weekly paclitaxel in patients with HER-2 negative metastatic breast cancer (MBC); Clinical Cancer Research; 2017 May; doi:10.1158/1078-0432.CCR-16-2748. PMID: 28539464 PMICD: PMC5600824

Kolev VN, Tam WF, Wright Q, McDermott SP, Vidal CM, Shapiro IM, Xu Q, Wicha M, Pachter JA, Weaver DT, Inhibition of FAK kinase activity preferentially targets cancer stem cells; Oncotarget - doi: 10.18632/oncotarget.18517; June 2017. PMID: 25486195 PMCID:  PMC4614818

Burnett JP, Lim G, Li Y, Shah RB, Lim R, Paholak HJ, McDermott SP, Sun L, Tsume Y, Bai S, Wicha MS, Sun D, Zhang T. Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells. Cancer Lett. 2017 May 28;394:52-64. doi: 10.1016/j.canlet.2017.02.023. Epub 2017 Feb 27. PMID: 28254410

Chen YC, Baac H, Lee KT, Fouladdel S, Teichert K, Ok J G, Cheng YH, Ingram P, Hart A J, Azizi E, Guo L J, Wicha M, Yoon E, Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analysis; ACS Nano, 2017 May 23. doi:10.1021/scsnano.7b00413. Epub 2017 May 8. PMID: 28480715

Wadehra M, Kiyohara M, Dillard C, Kim S, Lu J, Sachdev D, Goodglick L, Tao M, Torous V, Wang W, Gordon L, Braun J, McDermott S, Wicha M, Aryasomayajula C, Najafzadeh P, Tsui J, EMP2 is a novel therapeutic target for endometrial cancer cells; Oncogene - doi: 10.1038/onc2017.142. PMID: 28604744. PMCID: PMC5648618

Zou W, Nagarsheth N, Wicha M. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy; Nature Reviews Immunology - May 2017, doi:10.1038/nri.2017.49. PMID: 28555670

Tan Z, Nie S, McDermott SP, Wicha MS, Lubman DM. Single Amino Acid Variant Profilesof Subpopulations in the MCF-7 Breast Cancer Cell Line. J Proteome Res. 2017 Feb 3;16(2):842-851. doi: 10.1021/acs.jproteome.6b00824. Epub 2017 Jan 20. PMID: 28076950

Liu Y, Burness ML, Martin-Trevino R, Guy J, Bai S, Harouaka R, Brooks MD, Shang L, Fox A, Luther TK, Davis A, Baker TL, Colacino J, Clouthier SG, Shao ZM, Wicha MS, Liu S. RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer; Clinical Cancer Research. 2017 Jan 15;23(2):514-522. doi: 10.1158/1078-0432.CCR-15-1348. Epub 2016 Dec 29. PMID: 28034904

Jack RM, Hussain, K, Rodrigues D, Azizi, E, Wicha MS, Simeone D, Nagrath S. Microfluidic Continuum Sorting of Sub-Populations of Tumor Cells via Surface Antibody Expression Levels; Lab on a Chip, 2017, DOI: 10.1039/C6LC01496H. PMID: 28294230

2016 Publications

Prince M, Zhou L, Moyera J, Tao H, Lua L, Owen J, Etigena M, Zheng F, Chang A, Xia J, Wolf G, Max S Wicha, Huang S, Ren X, Li Q. Evaluation of the immunogenicity of ALDH high human head and neck squamous cell carcinoma cancer stem cells in vitro. Oral Oncology, 59:30-42, 2016 August. doi:10.1016/j.oraloncology.2016.05.013. PMID: 27424180

Hu Y, Lu L, Xia Y, Chen X, Chang A, Hollingsworth  R, Hurt E, Owen J, Moyer J, Prince M, Dai F, Bao Y, Wang Y, Whitfield J, Xia J, Huang S, Wicha M, Li Q. Therapeutic efficacy of cancer stem cell vaccines in the adjuvant setting. Cancer Research, 76(16):4661-72 2016, Aug 15. doi: 10.1158/0008-5472.CAN-15-2664. PMID: 27325649

Paholak H, Stevers N, Chen H, Burnett J, He M, Korkaya H, McDermott S, Deol Y, Clouthier S, Luther T, Li Q, Wicha MS, Sun, D. Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated phototermal therapy. Biomaterials, 104:145-57, 2016 June 23. doi: 10.1016/j.biomaterials.2016.06.045. PMID: 27450902

Chen Y, Zhang Z, Fouladdel S, Deol Y, Ingram P, McDermott S, Azizi E, Wicha M, Yoon E. Single Cell Dual Adherent-Suspension Co-Culture Micro-Environment for Studying Tumor-Stormal Interactions with Functionally Selected Cancer Stem-like Cells. Lab Chip, 16, 2935-2945, 2016. PMID: 27381658

Chen Y, Ingram P, Fouladdel S, McDermottS, Azizi E, Wicha M, Yoon E. High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis. Scientific Reports, 6, 27301. 2016. PMID: 27292795

Sun L, Burnett J, Gasparyan M, Xu F, Jiang H, Lin C, Myers I, Korkaya H, Liu Y,  Connarn J, He H, Zhang N, Wicha M, Sun D. Novel Cancer Stem Cell Targets during Epithelial to Mesenchymal Transition in PTEN-deficient Trastuzumab-resistant. Breast Cancer. Oncotarget. 2016 Jun 6. doi: 10.18632/oncotarget.9839. PMID: 27285982

Colacino JA, McDermott SP, Sartor MA, Wicha MS, Rozek LS. Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. Breast Cancer Research and Treatment, pp 1-13, June 15, 2016. PMID: 27306423

Hsu E, Kulp S, Huang H, Tu H, Chao M, Tseng Y, Yang M, Salunke S, Sullivan N, Chen W, Zhang J, Teng C, Fu W, Sun D, Wicha M, Shapiro C, Chen C. Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer. Carcinogenesis, 37(4) pp 430-442, April 1, 2016. PMID: 26905583

Finkel K, Warner, Kerk S, Bradford C, McLean S, Prince M, Zhong H, Hurt E, Hollingsworth R, Wicha M, Tice D, Nör J. IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence. Neoplasia, 18(5) pp 273-281, May 31, 2016. PMID: 27237319

Peng D, Tanikawa T, Li W, Zhao L, Vatan L, Szeliga W, Wan S, Wei S, Wang Y, Liu Y, Staroslawska E, Szubstarski F, Rolinski J, Grywalska E, Stanisławek A, Polkowski W, Kurylcio A, Kleer C, Chang A, Wicha M, Sabel M, Zou W, Kryczek I. Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling. Cancer Research, 76 (11) pp 3156-3165, June 1, 2016. PMID: 27197152

Murthy P, Kidwell KM, Schott AF, Merajver SD, Griggs JJ, Smerage JD, Van Poznak CH, Wicha MS, Hayes DF, Henry NL. Clinical predictors of long-term survival in HER2-positive metastatic breast cancer. Breast Cancer Research and Treatment. 2016 Feb 13. PMID: 26875184

Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone D, Wicha MS, Kim J, Nagrath S. Efficient capture and release of circulating tumor cells by temperature-sensitive polymer-graphene oxide composite. Advanced Materials, 2016 Apr 26; DOI:10.1002/adma.201600658, 2016. PMID: 27115557

Jack R, Grafton M, Rodrigues D,. Giraldez M,Griffith C, Cieslak R, Zenali M, Kumar-Sinha C, Azizi E, Wicha M,  Tewari M, Simeone D, and Nagrath S. Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling. Advanced Science, DOI: 10.1002/advs.201600063, 2016.

Zhong H, Davis A, Ouzounova M, Carrasco RA, Chen C, Breen S, Chang YS, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice DA, Clouthier SG, Xiao Z, Wicha MS, Korkaya H, Hollingsworth RE. A novel IL6 antibody sensitizes multiple tumor types to chemotherapy including trastuzumab-resistant tumors. Cancer Research, 76(2):480-490, 2016. PMID: 26744529

2015 Publications

Hsu E, Kulp S, Huang H, Tu H, Salunke S, Sullivan N, Sun D, Wicha M, Shapiro C, Chen C. Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating y-Secretase-Mediated Notch1 Activation in Caveolae. Neoplasia. 2015 June 30; 17(6), 497-508. PMID: 26152358

Kim G, Ouzounova M, Quraishi AA, Davis A, Tawakkol N, Clouthier S, Malik F, Paulson AK, D'Angelo RC, Korkaya S, Baker TL, Esen ES, Prat A, Liu S, Kleer CG, Thomas DG, Wicha MS, Korkaya H. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. Oncogene. 2015 Feb; 34 (6), 671-680. PMID: 24531711

Proctor E, Kidwell K, Jiagge E, Bensenhaver J, Awuah B, Gyan K, Toy K, Kwaku Oppong J, Kyei I, Aitpillah F, Osei-Bonsu E, Adjei E, l Ohene-Yeboah M, Newman Brewer R, Ahenkorah Fondjo L, Owusu-Afriyie O, Wicha MS, Merajver S, Kleer C, Newman L. Characterizing Breast Cancer in Population with Increased Prevalence of Triple-Negative Breast Cancer: Androgen Receptor and ALDH1 Expression in Ghanaian Women. Annals of surgical oncology. 2015 March 6, 1-5. PMID: 25743329

Malik F, Korkaya H, Clouthier S, Wicha MS. Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in Metastatic Niche. Principles of Stem Cell Biology and cancer, Future Applications and Therapeutics. 2015 May 1, 123-143.

Pan Q, Wang Q, Dan J, Pan K, Li Y, Zhang Y , Zhao J, Weng D, Tang Y, Huang L, He J, Chen S, Ke M, CHen M, Wicha MS, Chang A, Zeng Y, Li Q, Xia J. A Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma. Scientific reports. 2015 March 17; 5:9202 DOI: 10.1038/srep09202. PMID: 25776856

Brooks M, Wicha MS. Tumor Twitter: Cellular Communication in the Breast Cancer Stem Cell Niche. Cancer Discovery. 2015 May 4; 5(5), 469-71. DOI:10.1158/2159-8290.CD-15-0327

Lu L, Tao H, Chang A, Hu Y, Shu G, Chen Q, Egenti M, Owen J, Moyer J, Prince M, Huang S, Wicha MS, Xia J, Li Q. Cancer stem cells vaccine inhibits metastases of primary tumors and induces humoral immue responses against cancer stem cells. OncoImmunology. 2015 May 1; 4:3, e990767, DOI: 10.4161/2162402X.2014.990767

Pan Q, Li Q, Liu S, Ning N, Zhang Z, Xu, Chang AE, Wicha MS. Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells. 2015 Apr 15. PubMed PMID: 25873269

Conley SJ, Baker TL, Burnett JP, Theisen RL, Lazarus D, Peters CG, Clouthier SG, Eliasof S, Wicha MS. CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat. 2015 Apr 2. PubMed PMID: 25833208

Ke J, Zhao Z, Hong SH, Bai S, He Z, Malik F, Xu J, Zhou L, Chen W, Martin-Trevino R, Wu X, Lan P, Yi Y, Ginestier C, Ibarra I, Shang L, McDermott S, Luther T, Clouthier SG, Wicha MS, Liu S. Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells.Oncotarget. 2015 Jan 21. PubMed PMID: 2568682

D'Angelo RC, Ouzounova M, Davis A, Choi D, Tchuenkam SM, Kim G, Luther T, Quraishi AA, Senbabaoglu Y, Conley SJ, Clouthier SG, Hassan KA, Wicha MS, Korkaya H. Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. Mol Cancer Ther. 2015 Feb 11. PubMed PMID: 25673823.

Liu Y, Chen C, Qian P, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T, Zhao Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat Commun. 2015 Jan 23. PubMed PMID: 25612916

2014 Publications

Zhang Z, Shiratsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer DG, Ramnath N, Nagrath S. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget. 2014 Dec 15. PubMed PMID: 25474037.

Luo M, Brooks M, Wicha MS. Epithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistance. Curr Pharm Des. 2014 Dec 11. PubMed PMID: 25506895.

Murlidhar V, Zeinali M, Grabauskiene S, Ghannad-Rezaie M, Wicha MS, Simeone DM, Ramnath N, Reddy RM, Nagrath S. A radial flow microfluidic device for ultra-high throughput affinity-based isolation of circulating tumor cells. Small. 2014 Dec. PubMed PMID: 25074448.

Zhang Z, Shirarsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer RG, Ramnath N, Nagrath S. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget. 2014 1 Dec. PubMed PMID: 25474037.

Deng L, Shang L, Bai S, Chen J, He X, Trevino RM, Chen S, Li X, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginistier C, Ibarra I, Ke J, Luther TK, Clouthier SG, Xu L, Shan G, Song E, Yao H, Hannon GJ, Weiss SJ, Wicha MS, Liu S. microRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Res. 2014 Sep 12. PubMed PMID: 25217527.

Krishnamurthy S, Warner KA, Dong Z, Imai A, Nor C, Ward BB, Helman JI, Taichman RS, Bellile EL, McCauley LK, Polverini PJ, Prince ME, Wicha MS, Nor JE. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells. 2014 Jul 30. PubMed PMID: 25078284.

Lombardi S, Honeth G, Ginestier C, Shinomiya Y, Marlow R, Buchupalli B, Gazinska P, Brown J, Catchpole S, Liu S, Barkan A, Wicha M, Purushotham A, Burchell J, Pinder S, Dontu G. Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells. Stem Cell Reports. 2014 June 3; 2(6):780-93. PubMed PMID: 24936466. PMCID: PMC4050343

Kim G, Ouzounova M, Quraishi AA, Davis A, Tawakkol N, Clouthier SG, Malik F, Paulson AK, D'Angelo RC, Korkaya S, Baker TL, Esen ES, Prat A, Liu S, Kleer CG, Thomas DG, Wicha MS, Korkaya H. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. Oncogene. 2014 Feb 17. PubMed PMID: 24531711.

Liu S, Yin F, Zhang J, Wicha MS, Chang AE, Fan W, Chen L, Fan M, Li Q. Regulatory roles of miRNA in the human neural stem cell transformation to glioma stem cells. J Cell Biochem. 2014 Feb 12. PubMed PMID: 24519663.

Fearon ER, Wicha MS. KRAS and cancer stem cells in APC-mutant colorectal cancer. J Natl Cancer Inst. 2014 Feb 1; 106(2). PubMed PMID: 24491303.

Wicha MS. Targeting self-renewal, an Achilles' heel of cancer stem cells. Nat Med. 2014 Jan 7;20(1): 14-5. PubMed PMID 24398956.

Li Q, Lu L, Tao H, Xue C, Teitz-Tennenbaum S, Owen JH, Moyer JS, Prince ME, Chang AE, Wicha MS. Generation of a novel dendritic-cell vaccine using melanoma and squamous cancer stem cells. J Vis Exp. 2014 Jan 6; (83). PubMed PMID: 24430104. PubMed Central PMCID: PMC4063547

Wang SH, Lu L, Fan Y, Wicha MS, Cao Z, Chang AE, Xia J, Baker JR Jr., Li, Q. Characterization of a novel transgenic mouse tumor model for targeting HER2+ cancer stem cells. Int J Biol Sci. 10(1): 25-32. PubMed PMID: 24391448

2013 Publications

Liu, S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, Martin-Trevino R, Shang L, McDermott SP, Landis MD, Hong S, Adams A, D'Angelo R, Ginestier C, Charafe-Jauffret E, Clouthier SG, Birnbaum D, Wong ST, Zhan M, Chang JC, Wicha MS. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports 2013 Dec 27; 2(1): 78-91. PubMed PMID: 24511467.

Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao C, Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J. Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24- Subpopulations of Breast Cancer Cells.
PLoS One. 2013 Dec 23;8(12):e82821. PubMed PMID: 24376586

Conley SJ, Wicha MS. Breast Cancer Stem Cells: From Theory to Therapy. In: Sell S, editor. Stem Cells Handbook. Springer New York; 2013 p. 477–89.

Huang J, Li C, Wang Y, Lv H, Guo Y, Dai H, et al. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin Immunol. 2013 Oct;149(1):156–68. PubMed PMID: 23994769.

Yoon HJ, Kim TH, Zhang Z, Azizi E, Pham TM, Paoletti C, Lin J, Ramnath N, Wicha MS, Hayes DF, Simeone DM, Nagrath S. Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol. 2013 Sep 29. PubMed PMID: 24077027

Luo M, Zhao X, Chen, S, Liu S, Wicha MS, Guan JL. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Research. 2013; 73(17): 5591-602. PubMed PMID: 23832665.

Vu-Phan D, Grachtchouk V, Yu J, Colby LA, Wicha MS, Koenig RJ. The thyroid cancer PAX9-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype. Endocrine-Related Cancer. 2013; 20(5), 725-739. PubMed PMID: 24025583.

Cui TX, Kryczek I, Zhao L, Zhao E, Kuick R, Roh MH, et al. Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2. Immunity. 2013 Sep 4. PubMed PMID: 24012420.

Korkaya H, Wicha MS. HER2 and breast cancer stem cells: More than meets the eye. Cancer Res. 2013 Jun 15;73(12):3489090. PubMed PMID: 23740771.

Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res. 2013 Feb 26. PubMed PMID: 23444212.

Ithimakin S, Day KC, Malik F, Zen Q, Dawsey SJ, Bersano-Begey TF, Quraishi AA, Ignatoski KW, Daignault S, Davis A, Hall CL, Palanisamy N, Heath AN, Tawakkol N, Luther TK, Clouthier SG, Chadwick WA, Day ML, Kleer CG, Thomas DG, Hayes DF, Korkaya H, Wicha MS. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res. 2013 Feb 26. PubMed PMID: 23442322.

Wicha MS. B4 androgen ablation: Attacking the prostate cancer stem cell. J Clin. Invest. 2013 Jan 25: 1-3. PubMed PMID: 23348735.

Schott AF, Landis M, Dontu G, Griffith KA, Layman RM, Krop I, Paskett LA, Wong H, Drobolecki LE, Froehlich AM, Paranilam J, Hayes DF, Wicha MS, Chang JC. Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin. Cancer Res. 2013 Jan 22. PubMed PMID: 23340294.

Azizi E, Wicha MS. Cancer Stem Cells--The Evidence Accumulates. Clin. Chem. 2013 Jan. PubMed PMID: 23143328.

2012 Publications

Wicha MS, Korkaya H. Breast Cancer Stem Cells: We’ve got them surrounded. Clin. Cancer Res. 2012 Dec 18. PubMed PMID: 23251003.

Teitz-Tennenbaum S, Wicha MS, Chang AE, Li Q. Targeting cancer stem cells via dendritic-cell vaccination. Oncoimmunology. 2012 Nov 1;1(8):1401–3. PubMed PMID: 23243607.

Wicha MS. Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame? Breast Cancer Res. 2012 Nov 15;14(6):114. PubMed PMID: 23153392.

Duru N, Fan M, Candas D, Menaa C, Liu H-C, Nantajit D, et al. HER2-associated radiation resistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin. Cancer Res. 2012 Oct 22. PubMed PMID: 23091114.

Petrillo LA, Wolf DM, Kapoun AM, Wang NJ, Barczak A, Xiao Y, Korkaya H, Baehner F, Lewicki J, Wicha M, Park JW, Spellman PT, Gray JW, Van’t Veer L, Esserman LJ. Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors. Breast Cancer Res. Treat. 2012 Oct;135(3):913–922. PubMed PMID: 22941572.

Schwartz T, Stark A, Pang J, Awuah B, Kleer CG, Quayson S, Kingman S, Aitpillah F, Abantanga F, Jiagge E, Oppong JK, Osei-Bonsu E, Martin I, Yan X, Toy K, Adjei E, Wicha M, Newman LA. Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women. Cancer 2012 Aug. PubMed PMID: 22930220.

Malik F, Korkaya H, Clouthier SG, Wicha MS. Breast cancer heterogeneity: Need to review current treatment strategies. Curr Breast Cancer Rep. 2012 Aug, 4(4): 225-231.

Malik F, Korkaya H, Clouthier SG, Wicha MS. Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer. Cell Cycle 2012 Aug;11(15):2780–2781. PubMed PMID: 22833047.

Korkaya H, Kim G-I, Davis A, Malik F, Henry NL, Ithimakin S, Quraishi AA, Tawakkol N, D’Angelo R, Paulson AK, Chung S, Luther T, Paholak HJ, Liu S, Hassan KA, Zen Q, Clouthier SG, Wicha MS. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.Molecular Cell 2012 Jul 19. PubMed PMID: 22819326.

Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, McDermott SP, Shang L, Ke J, Ou SJ, Heath A, Zhang KJ, Korkaya H, Clouthier SG, Charafe-Jauffret E, Birnbaum D, Hannon GJ, Wicha MS. MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet. 2012 Jun 7;8(6):e1002751. PubMed PMID: 22685420.

Wicha MS. PSA lo and behold: Prostate cancer stem cells. Cell Stem Cell. 2012 May 4;10(5):482–3. PubMed PMID: 22560068.

Liu S, Korkaya H, Wicha MS. Are cancer stem cells ready for prime time? The Scientist, 2012 Apr.  Available from: http://the-scientist.com/2012/04/01/are-cancer-stem-cells-ready-for-prime-time/

Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince MEP, Xu Y, Zhang X-L, Huang S, Chang AE, Li Q. Cancer stem cell vaccination confers significant antitumor immunity. Cancer Research 2012 Apr;72(7):1853–1864. PubMed PMID: 22473314

Conley SJ, Wicha MS. Reply to Nugue and Wion: Targeting cancer stem cells’ hypoxic core. PNAS. 2012 Apr 17;109(16):E915. doi: 10.1073/pnas.1203321109

Conley SJ, Wicha MS. Antiangiogenic agents: Fueling cancer’s hypoxic roots. Cell Cycle 2012 Apr;11(7). PubMed PMID: 22421155

Liu S, Clouthier SG, Wicha MS. Role of microRNAs in the regulation of breast cancer stem cells. Journal of Mammary Gland Biology and Neoplasia; 2012 Feb. PubMed PMID: 22331423.

Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, Clouthier SG, Wicha MS. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proceedings of the National Academy of Sciences of the United States of America; 2012 Jan. PubMed PMID: 22308314.

2011 Publications

Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J. Clin. Invest. 2011 Oct;121(10):3804–3809. PubMed PMID: 21965337. PubMed Central PMCID: 3223613.

Zielske SP, Spalding AC, Wicha MS, Lawrence TS. Ablation of breast cancer stem cells with radiation. Transl Oncol 2011 Aug;4(4):227-233. PubMed PMID: 21804918. PubMed Central PMCID: PMC3140010.

Korkaya H, Wicha MS. Inflammation and autophagy conspire to promote tumor growth. Cell Cycle 2011 Aug;10(16):2623. PubMed PMID: 21829104.

Korkaya H, Liu S, Wicha MS. Regulation of cancer stem cells by cytokine networks: Attacking cancers inflammatory roots. Clin Cancer Res 2011 Jun. PubMed PMID: 21685479.

Henry NL, Banerjee M, Wicha M, Van Poznak C, Smerage JB, Schott AF, Griggs JJ, Hayes DF. Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms. Cancer 2011 Jun. PubMed PMID: 21692065.

Reddy RM, Kakarala M, Wicha MS. Clinical trial design for testing the stem cell model for the prevention and treatment of cancer. Cancers (Basel). 2011;3(2):2696–708. PubMed PMID: 24212828

Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R, Wicha MS, Ethier SP, Yang Z-Q. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene 2011 June 13. PubMed PMID: 21666724.

Silva IA, Bai S, McLean K, Yang K, Griffith KA, Dafydd T, Ginestier C, Johnston C, Kueck A, Reynolds K, Wicha MS, Buckanovich RJ. Aldehyde dehydrogenase and CD133 define angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res 2011 Apr. PubMed PMID: 21498635. PubMed Central PMCID: PMC3107359.

Kryczek I, Liu S, Roh M, Vatan L, Szeliga W, Wei S, Banerjee M, Mao Y, Kotarski J, Wicha MS, Liu R, Zou W. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer 2011 Feb. PubMed PMID: 21480217. PubMed Central PMCID: PMC3164893.

Wicha MS, Hayes DF. Circulating tumor cells: Not all detected cells are bad and not all bad cells are detected. J Clin Oncol 2011 Mar. PubMed PMID: 21422428.   

Li Y, Wicha MS, Schwartz SJ, Sun D. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem 2011 Feb. PubMed PMID: 21295962.

Wicha MS. Stemming a tumor with a little miR. Nat. Med 2011 Feb;17(2):162-164.  PubMed PMID: 21297608.

Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, Korkaya H, Heath A, Dutcher J, Kleer CG, Jung Y, Dontu G, Taichman R, Wicha MS. Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Res 2011 Jan;71(2):614-624.  PubMed PMID: 21224357. PubMed Central PMCID: PMC3100554.

2010 Publications

Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE. Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 2010 Dec;70(23):9969-9978. PubMed PMID: 21098716. PubMed Central PMCID: PMC3058885.

D'Angelo RC, Wicha MS. Stem cells in normal development and cancer. Prog Mol Biol Transl Sci 2010;95:113-158. PubMed PMID: 21075331.

Stark A, Kleer CG, Martin I, Awuah B, Nsiah-Asare A, Takyi V, Braman M, Quayson SE, Zarbo R, Wicha M, Newman L. African ancestry and higher prevalence of triple-negative breast cancer: findings from an international study. Cancer 2010 Nov;116(21):4926-4932. PubMed PMID: 20629078. PubMed Central PMCID: PMC3138711.

McDermott SP, Wicha MS. Targeting breast cancer stem cells. Mol Oncol. 2010 Oct;4(5):404-19. Epub 2010 Jun 17. PubMed PMID: 20599450. PubMed Central PMCID: PMC3023958.

McDermott SP, Wicha MS. Breast tumors: of mice and women. Breast Cancer Res. 2010;12(3):108. Epub 2010 May 27. PubMed PMID: 20550730; PubMed Central PMCID: PMC2917013.

Liu S, Wicha MS. Targeting breast cancer stem cells. J Clin Oncol. 2010 Sep 1;28(25):4006-12. Epub 2010 May 24. Review. PubMed PMID: 20498387.

Korkaya H, Wicha MS. Cancer stem cells: nature versus nurture. Nat Cell Biol. 2010 May;12(5):419-21. Epub 2010 Apr 25. PubMed PMID: 20418873.

Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res. 2010 May 1;16(9):2580-90. Epub 2010 Apr 13. PubMed PMID: 20388854; PubMed Central PMCID: PMC2862133.

Clay MR, Tabor M, Owen JH, Carey TE, Bradford CR, Wolf GT, Wicha MS, Prince ME. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck. 2010 Sep;32(9):1195-201. PubMed PMID: 20073073. PubMed Central PMCID: PMC2991066.

Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest. 2010 Feb 1;120(2):485-97. Epub 2010 Jan 4. PubMed PMID: 20051626; PubMed Central PMCID: PMC2810075.

Iniesta MD, Chien J, Wicha M, Merajver SD. One-hit effects and cancer. Cancer Prev Res (Phila) 2010 Jan;3(1):12-15. PubMed PMID: 20051368.

Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, Esterni B, Houvenaeghel G, Extra JM, Bertucci F, Jacquemier J, Xerri L, Dontu G, Stassi G, Xiao Y, Barsky SH, Birnbaum D, Viens P, Wicha MS. Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res. 2010 Jan 1;16(1):45-55. Epub 2009 Dec 22. PubMed PMID: 20028757; PubMed Central PMCID: PMC2874875.

Kakarala M, Brenner DE, Korkaya H, Cheng C, Tazi K, Ginestier C, Liu S, Dontu G, Wicha MS. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat. 2010 Aug;122(3):777-85. Epub 2009 Nov 7. PubMed PMID: 19898931. PubMed Central PMCID: PMC3039120.

Publication archives (2000 - 2009)

Book chapters

AACR abstracts (2006 - 2015)