Archives (2000 - 2013)


Liu, S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, Martin-Trevino R, Shang L, McDermott SP, Landis MD, Hong S, Adams A, D'Angelo R, Ginestier C, Charafe-Jauffret E, Clouthier SG, Birnbaum D, Wong ST, Zhan M, Chang JC, Wicha MS. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports 2013 Dec 27; 2(1): 78-91. PubMed PMID: 24511467.

Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao C, Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J. Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24- Subpopulations of Breast Cancer Cells.
PLoS One. 2013 Dec 23;8(12):e82821. PubMed PMID: 24376586

Conley SJ, Wicha MS. Breast Cancer Stem Cells: From Theory to Therapy. In: Sell S, editor. Stem Cells Handbook. Springer New York; 2013 p. 477–89.

Huang J, Li C, Wang Y, Lv H, Guo Y, Dai H, et al. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin Immunol. 2013 Oct;149(1):156–68. PubMed PMID: 23994769.

Yoon HJ, Kim TH, Zhang Z, Azizi E, Pham TM, Paoletti C, Lin J, Ramnath N, Wicha MS, Hayes DF, Simeone DM, Nagrath S. Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol. 2013 Sep 29. PubMed PMID: 24077027

Luo M, Zhao X, Chen, S, Liu S, Wicha MS, Guan JL. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Research. 2013; 73(17): 5591-602. PubMed PMID: 23832665.

Vu-Phan D, Grachtchouk V, Yu J, Colby LA, Wicha MS, Koenig RJ. The thyroid cancer PAX9-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype. Endocrine-Related Cancer. 2013; 20(5), 725-739. PubMed PMID: 24025583.

Cui TX, Kryczek I, Zhao L, Zhao E, Kuick R, Roh MH, et al. Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2. Immunity. 2013 Sep 4. PubMed PMID: 24012420.

Korkaya H, Wicha MS. HER2 and breast cancer stem cells: More than meets the eye. Cancer Res. 2013 Jun 15;73(12):3489090. PubMed PMID: 23740771.

Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res. 2013 Feb 26. PubMed PMID: 23444212.

Ithimakin S, Day KC, Malik F, Zen Q, Dawsey SJ, Bersano-Begey TF, Quraishi AA, Ignatoski KW, Daignault S, Davis A, Hall CL, Palanisamy N, Heath AN, Tawakkol N, Luther TK, Clouthier SG, Chadwick WA, Day ML, Kleer CG, Thomas DG, Hayes DF, Korkaya H, Wicha MS. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res. 2013 Feb 26. PubMed PMID: 23442322.

Wicha MS. B4 androgen ablation: Attacking the prostate cancer stem cell. J Clin. Invest. 2013 Jan 25: 1-3. PubMed PMID: 23348735.

Schott AF, Landis M, Dontu G, Griffith KA, Layman RM, Krop I, Paskett LA, Wong H, Drobolecki LE, Froehlich AM, Paranilam J, Hayes DF, Wicha MS, Chang JC. Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin. Cancer Res. 2013 Jan 22. PubMed PMID: 23340294.

Azizi E, Wicha MS. Cancer Stem Cells--The Evidence Accumulates. Clin. Chem. 2013 Jan. PubMed PMID: 23143328.


Wicha MS, Korkaya H. Breast Cancer Stem Cells: We’ve got them surrounded. Clin. Cancer Res. 2012 Dec 18. PubMed PMID: 23251003.

Teitz-Tennenbaum S, Wicha MS, Chang AE, Li Q. Targeting cancer stem cells via dendritic-cell vaccination. Oncoimmunology. 2012 Nov 1;1(8):1401–3. PubMed PMID: 23243607.

Wicha MS. Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame? Breast Cancer Res. 2012 Nov 15;14(6):114. PubMed PMID: 23153392.

Duru N, Fan M, Candas D, Menaa C, Liu H-C, Nantajit D, et al. HER2-associated radiation resistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin. Cancer Res. 2012 Oct 22. PubMed PMID: 23091114.

Petrillo LA, Wolf DM, Kapoun AM, Wang NJ, Barczak A, Xiao Y, Korkaya H, Baehner F, Lewicki J, Wicha M, Park JW, Spellman PT, Gray JW, Van’t Veer L, Esserman LJ. Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors. Breast Cancer Res. Treat. 2012 Oct;135(3):913–922. PubMed PMID: 22941572.

Schwartz T, Stark A, Pang J, Awuah B, Kleer CG, Quayson S, Kingman S, Aitpillah F, Abantanga F, Jiagge E, Oppong JK, Osei-Bonsu E, Martin I, Yan X, Toy K, Adjei E, Wicha M, Newman LA. Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women. Cancer 2012 Aug. PubMed PMID: 22930220.

Malik F, Korkaya H, Clouthier SG, Wicha MS. Breast cancer heterogeneity: Need to review current treatment strategies. Curr Breast Cancer Rep. 2012 Aug, 4(4): 225-231.

Malik F, Korkaya H, Clouthier SG, Wicha MS. Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer. Cell Cycle 2012 Aug;11(15):2780–2781. PubMed PMID: 22833047.

Korkaya H, Kim G-I, Davis A, Malik F, Henry NL, Ithimakin S, Quraishi AA, Tawakkol N, D’Angelo R, Paulson AK, Chung S, Luther T, Paholak HJ, Liu S, Hassan KA, Zen Q, Clouthier SG, Wicha MS. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.Molecular Cell 2012 Jul 19. PubMed PMID: 22819326.

Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, McDermott SP, Shang L, Ke J, Ou SJ, Heath A, Zhang KJ, Korkaya H, Clouthier SG, Charafe-Jauffret E, Birnbaum D, Hannon GJ, Wicha MS. MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet. 2012 Jun 7;8(6):e1002751. PubMed PMID: 22685420.

Wicha MS. PSA lo and behold: Prostate cancer stem cells. Cell Stem Cell. 2012 May 4;10(5):482–3. PubMed PMID: 22560068.

Liu S, Korkaya H, Wicha MS. Are cancer stem cells ready for prime time? The Scientist, 2012 Apr.  Available from:

Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince MEP, Xu Y, Zhang X-L, Huang S, Chang AE, Li Q. Cancer stem cell vaccination confers significant antitumor immunity. Cancer Research 2012 Apr;72(7):1853–1864. PubMed PMID: 22473314

Conley SJ, Wicha MS. Reply to Nugue and Wion: Targeting cancer stem cells’ hypoxic core. PNAS. 2012 Apr 17;109(16):E915. doi: 10.1073/pnas.1203321109

Conley SJ, Wicha MS. Antiangiogenic agents: Fueling cancer’s hypoxic roots. Cell Cycle 2012 Apr;11(7). PubMed PMID: 22421155

Liu S, Clouthier SG, Wicha MS. Role of microRNAs in the regulation of breast cancer stem cells. Journal of Mammary Gland Biology and Neoplasia; 2012 Feb. PubMed PMID: 22331423.

Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, Clouthier SG, Wicha MS. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proceedings of the National Academy of Sciences of the United States of America; 2012 Jan. PubMed PMID: 22308314.


Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J. Clin. Invest. 2011 Oct;121(10):3804–3809. PubMed PMID: 21965337. PubMed Central PMCID: 3223613.

Zielske SP, Spalding AC, Wicha MS, Lawrence TS. Ablation of breast cancer stem cells with radiation. Transl Oncol 2011 Aug;4(4):227-233. PubMed PMID: 21804918. PubMed Central PMCID: PMC3140010.

Korkaya H, Wicha MS. Inflammation and autophagy conspire to promote tumor growth. Cell Cycle 2011 Aug;10(16):2623. PubMed PMID: 21829104.

Korkaya H, Liu S, Wicha MS. Regulation of cancer stem cells by cytokine networks: Attacking cancers inflammatory roots. Clin Cancer Res 2011 Jun. PubMed PMID: 21685479.

Henry NL, Banerjee M, Wicha M, Van Poznak C, Smerage JB, Schott AF, Griggs JJ, Hayes DF. Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms. Cancer 2011 Jun. PubMed PMID: 21692065.

Reddy RM, Kakarala M, Wicha MS. Clinical trial design for testing the stem cell model for the prevention and treatment of cancer. Cancers (Basel). 2011;3(2):2696–708. PubMed PMID: 24212828

Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R, Wicha MS, Ethier SP, Yang Z-Q. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene 2011 June 13. PubMed PMID: 21666724.

Silva IA, Bai S, McLean K, Yang K, Griffith KA, Dafydd T, Ginestier C, Johnston C, Kueck A, Reynolds K, Wicha MS, Buckanovich RJ. Aldehyde dehydrogenase and CD133 define angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res 2011 Apr. PubMed PMID: 21498635. PubMed Central PMCID: PMC3107359.

Kryczek I, Liu S, Roh M, Vatan L, Szeliga W, Wei S, Banerjee M, Mao Y, Kotarski J, Wicha MS, Liu R, Zou W. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer 2011 Feb. PubMed PMID: 21480217. PubMed Central PMCID: PMC3164893.

Wicha MS, Hayes DF. Circulating tumor cells: Not all detected cells are bad and not all bad cells are detected. J Clin Oncol 2011 Mar. PubMed PMID: 21422428.   

Li Y, Wicha MS, Schwartz SJ, Sun D. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem 2011 Feb. PubMed PMID: 21295962.

Wicha MS. Stemming a tumor with a little miR. Nat. Med 2011 Feb;17(2):162-164.  PubMed PMID: 21297608.

Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, Korkaya H, Heath A, Dutcher J, Kleer CG, Jung Y, Dontu G, Taichman R, Wicha MS. Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Res 2011 Jan;71(2):614-624.  PubMed PMID: 21224357. PubMed Central PMCID: PMC3100554.


Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE. Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 2010 Dec;70(23):9969-9978. PubMed PMID: 21098716. PubMed Central PMCID: PMC3058885.

D'Angelo RC, Wicha MS. Stem cells in normal development and cancer. Prog Mol Biol Transl Sci 2010;95:113-158. PubMed PMID: 21075331.

Stark A, Kleer CG, Martin I, Awuah B, Nsiah-Asare A, Takyi V, Braman M, Quayson SE, Zarbo R, Wicha M, Newman L. African ancestry and higher prevalence of triple-negative breast cancer: findings from an international study. Cancer 2010 Nov;116(21):4926-4932. PubMed PMID: 20629078. PubMed Central PMCID: PMC3138711.

McDermott SP, Wicha MS. Targeting breast cancer stem cells. Mol Oncol. 2010 Oct;4(5):404-19. Epub 2010 Jun 17. PubMed PMID: 20599450. PubMed Central PMCID: PMC3023958.

McDermott SP, Wicha MS. Breast tumors: of mice and women. Breast Cancer Res. 2010;12(3):108. Epub 2010 May 27. PubMed PMID: 20550730; PubMed Central PMCID: PMC2917013.

Liu S, Wicha MS. Targeting breast cancer stem cells. J Clin Oncol. 2010 Sep 1;28(25):4006-12. Epub 2010 May 24. Review. PubMed PMID: 20498387.

Korkaya H, Wicha MS. Cancer stem cells: nature versus nurture. Nat Cell Biol. 2010 May;12(5):419-21. Epub 2010 Apr 25. PubMed PMID: 20418873.

Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res. 2010 May 1;16(9):2580-90. Epub 2010 Apr 13. PubMed PMID: 20388854; PubMed Central PMCID: PMC2862133.

Clay MR, Tabor M, Owen JH, Carey TE, Bradford CR, Wolf GT, Wicha MS, Prince ME. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck. 2010 Sep;32(9):1195-201. PubMed PMID: 20073073. PubMed Central PMCID: PMC2991066.

Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest. 2010 Feb 1;120(2):485-97. Epub 2010 Jan 4. PubMed PMID: 20051626; PubMed Central PMCID: PMC2810075.

Iniesta MD, Chien J, Wicha M, Merajver SD. One-hit effects and cancer. Cancer Prev Res (Phila) 2010 Jan;3(1):12-15. PubMed PMID: 20051368.

Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, Esterni B, Houvenaeghel G, Extra JM, Bertucci F, Jacquemier J, Xerri L, Dontu G, Stassi G, Xiao Y, Barsky SH, Birnbaum D, Viens P, Wicha MS. Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res. 2010 Jan 1;16(1):45-55. Epub 2009 Dec 22. PubMed PMID: 20028757; PubMed Central PMCID: PMC2874875.

Kakarala M, Brenner DE, Korkaya H, Cheng C, Tazi K, Ginestier C, Liu S, Dontu G, Wicha MS. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat. 2010 Aug;122(3):777-85. Epub 2009 Nov 7. PubMed PMID: 19898931. PubMed Central PMCID: PMC3039120.


Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan J. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 2009 Jan;69(2):466-474. PubMed PMID: 19147559.

Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, Hur M, Diebel ME, Monville F, Dutcher J, Brown M, Viens P, Xerri L, Bertucci F, Stassi G, Dontu G, Birnbaum D, Wicha MS. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009 Feb;69(4):1302-1313. PubMed PMID: 19190339. PubMed Central PMCID: 2819227.

Lewis MT, Wicha MS. Tumor-initiating cells and treatment resistance: how goes the war? J Mammary Gland Biol Neoplasia 2009 Mar;14(1):1-2. PubMed PMID: 19238526.

Korkaya H, Wicha MS. HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin. Cancer Res 2009 Mar;15(6):1845-1847.  PubMed PMID: 19276254.

Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009 Apr;69(8):3382-3389. PubMed PMID: 19336570. PubMed Central PMCID: 2789401.

Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 2009 Jun;7(6):e1000121. PubMed PMID: 19492080. PubMed Central PMCID: 2683567.

Ginestier C, Liu S, Wicha MS. Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell 2009 Sep;5(3):229-230. PubMed PMID: 19733528.

Wicha MS. Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. Breast Cancer Res 2009;11(5):108. PubMed PMID: 19804613. PubMed Central PMCID: 2790845.

Ginestier C, Wicinski J, Cervera N, Monville F, Finetti P, Bertucci F, Wicha MS, Birnbaum D, Charafe-Jauffret E. Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle 2009 Oct;8(20):3297-3302. PubMed PMID: 19806016. PubMed Central PMCID: 2861502.

Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG. An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin. Cancer Res 2009 Oct;15(20):6386-6390. PubMed PMID: 19808871. PubMed Central PMCID: 2787085

Gur D, Liu S, Shukla A, Pero SC, Wicha MS, Krag DN. Identification of single chain antibodies to breast cancer stem cells using phage display. Biotechnol. Prog 2009 Dec;25(6):1780-1787. PubMed PMID: 19899107.

Wicha MS. Targeting breast cancer stem cells. Breast 2009 Oct;18 Suppl 3:S56-58. PubMed PMID: 19914544.


Eliane J-P, Repollet M, Luker KE, Brown M, Rae JM, Dontu G, et al. Monitoring serial changes in circulating human breast cancer cells in murine xenograft models. Cancer Res. 2008 Jul 15;68(14):5529–32. PubMed PMID: 18632603. PubMed Central: PMC2789403.

Charafe-Jauffret E, Monville F, Ginestier C, Dontu G, Birnbaum D, Wicha MS. Cancer stem cells in breast: current opinion and future challenges. Pathobiology 2008;75(2):75-84. PubMed PMID: 18544962. PubMed Central PMCID: 2789397.

Wicha MS. Cancer stem cell heterogeneity in hereditary breast cancer. Breast Cancer Res 2008;10(2):105. PubMed PMID: 18423071. PubMed Central PMCID: 2397530.

Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, Dontu G, Wicha MS. BRCA1 regulates human mammary stem/progenitor cell fate. Proc. Natl. Acad. Sci. U.S.A 2008 Feb;105(5):1680-1685. PubMed PMID: 18230721. PubMed Central PMCID: 2234204.

Boman BM, Wicha MS. Cancer stem cells: a step toward the cure. J. Clin. Oncol 2008 Jun;26(17):2795-2799. PubMed PMID: 18539956.

Kakarala M, Wicha MS. Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J. Clin. Oncol 2008 Jun;26(17):2813-2820. PubMed PMID: 18539959. PubMed Central PMCID: 2789399.

Korkaya H, Paulson A, Iovino F, Wicha MS. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008 Oct;27(47):6120-6130. PubMed PMID: 18591932. PubMed Central PMCID: 2602947.

Huang EH, Wicha MS. Colon cancer stem cells: implications for prevention and therapy. Trends Mol Med 2008 Nov;14(11):503-509. PubMed PMID: 18929507. PubMed Central PMCID: 2789402.

Charafe-Jauffret E, Ginestier C, Monville F, Wicinski J, Bertucci F, Viens P, Xerri L, Cabaud O, Dontu G, Wicha MS, Birnbaum D. [Stem cells and epithelial cancers: the example of breast cancer]. Ann Pathol 2008 Nov;28 Spec No 1(1):S30-32. PubMed PMID: 18984292.


Boman BM, Wicha MS, Fields JZ, Runquist OA. Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approaches. Clin. Pharmacol. Ther 2007 Jun;81(6):893-898. PubMed PMID: 17460605.

Ginestier C, Wicha MS. Mammary stem cell number as a determinate of breast cancer risk. Breast Cancer Res 2007;9(4):109. PubMed PMID: 17688678.

Wicha MS. Breast cancer stem cells: the other side of the story. Stem Cell Rev 2007 Jun;3(2):110-112; discussion 113. PubMed PMID: 17873342.

Ashkenazi R, Jackson TL, Dontu G, Wicha MS. Breast cancer stem cells-research opportunities utilizing mathematical modeling. Stem Cell Rev 2007 Jun;3(2):176-182. PubMed PMID: 17873350.

Korkaya H, Wicha MS. Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs 2007;21(5):299-310. PubMed PMID: 17896836.

Kakarala M, Wicha MS. Cancer stem cells: implications for cancer treatment and prevention. Cancer J 2007 Oct;13(5):271-275. PubMed PMID: 17921723.

Ginestier C, Korkaya H, Dontu G, Birnbaum D, Wicha MS, Charafe-Jauffret E. [The cancer stem cell: the breast cancer driver]. Med Sci (Paris) 2007 Dec;23(12):1133-1139. PubMed PMID: 18154716.

** Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007 Nov;1(5):555-567. PubMed PMID: 18371393. PubMed Central PMCID: 2423808.
** Top 10 most highly cited Cell Stem Cell articles from 2007 - 2012:


Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea--a paradigm shift. Cancer Res 2006 Feb;66(4):1883-1890; discussion 1895-1896. PubMed PMID: 16488983.

Liu S, Dontu G, Mantle ID, Patel S, Ahn N, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006 Jun;66(12):6063-6071. PubMed PMID: 16778178.

Wicha MS. Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis. Breast Cancer Res 2006;8(5):109. PubMed PMID: 16934104. PubMed Central PMCID: 1779494.

Wicha MS. Cancer stem cells and metastasis: lethal seeds. Clin. Cancer Res 2006 Oct;12(19):5606-5607. PubMed PMID: 17020960.


Dontu G, Wicha MS. Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia 2005 Jan;10(1):75-86. PubMed PMID: 15886888.

Liu S, Dontu G, Wicha MS. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7(3):86-95. PubMed PMID: 15987436. PubMed Central PMCID: 1143566.

Dontu G, Liu S, Wicha MS. Stem cells in mammary development and carcinogenesis: implications for prevention and treatment. Stem Cell Rev 2005;1(3):207-213. PubMed PMID: 17142857.


Dontu G, El-Ashry D, Wicha MS. Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol. Metab 2004 Jul;15(5):193-197. PubMed PMID: 15223047.

Spahlinger DA, Pai C, Waldinger MB, Billi JE, Wicha MS. New organizational and funds flow models for an academic cancer center. Acad Med 2004 Jul;79(7):623-627. PubMed PMID: 15234911.

Dontu G, Jackson KW, McNicholas E, Kawamura MJ, Abdallah WM, Wicha MS. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 2004;6(6):R605-615. PubMed PMID: 15535842. PubMed Central PMCID: 1064073.


Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A 2003 Apr;100(7):3983-3988. PubMed PMID: 12629218. PubMed Central PMCID: 153034.

Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003 May;17(10):1253-1270. PubMed PMID: 12756227. PubMed Central PMCID: 196056.

Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS. Stem cells in normal breast development and breast cancer. Cell Prolif 2003 Oct;36 Suppl 1:59-72. PubMed PMID: 14521516.


Sumantran VN, Zhang R, Lee DS, Wicha MS. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Cancer Epidemiol. Biomarkers Prev 2000 Mar;9(3):257-263. PubMed PMID: 10750663.

Sumantran VN, Lee DS, Baker VV, Murray S, Strawderman M, Wicha MS. A bcl-x(S) adenovirus demonstrates therapeutic efficacy in an ascites model of human breast cancer. J. Soc. Gynecol. Investig 2000 Jun;7(3):184-189. PubMed PMID: 10865187.

Bennett CL, Stinson TJ, Vogel V, Robertson L, Leedy D, O'Brien P, Hobbs J, Sutton T, Ruckdeschel JC, Chirikos TN, Weiner RS, Ramsey MM, Wicha MS. Evaluating the financial impact of clinical trials in oncology: results from a pilot study from the Association of American Cancer Institutes/Northwestern University clinical trials costs and charges project. J. Clin. Oncol 2000 Aug;18(15):2805-2810. PubMed PMID: 10920127.

Sumantran VN, Lee DS, Woods Ignatoski KM, Ethier SP, Wicha MS. A bcl-xS adenovirus selectively induces apoptosis in transformed cells compared to normal mammary cells. Neoplasia 2000 Jun;2(3):251-260. PubMed PMID: 10935511. PubMed Central PMCID: 1507566.

Hernandez-Alcoceba R, Pihalja M, Wicha MS, Clarke MF. A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors. Hum. Gene Ther 2000 Sep;11(14):2009-2024. PubMed PMID: 11020800.