Archives (2000 - 2009)
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Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan J. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 2009 Jan;69(2):466-474. PubMed PMID: 19147559.

Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, Hur M, Diebel ME, Monville F, Dutcher J, Brown M, Viens P, Xerri L, Bertucci F, Stassi G, Dontu G, Birnbaum D, Wicha MS. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009 Feb;69(4):1302-1313. PubMed PMID: 19190339. PubMed Central PMCID: 2819227.

Lewis MT, Wicha MS. Tumor-initiating cells and treatment resistance: how goes the war? J Mammary Gland Biol Neoplasia 2009 Mar;14(1):1-2. PubMed PMID: 19238526.

Korkaya H, Wicha MS. HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin. Cancer Res 2009 Mar;15(6):1845-1847.  PubMed PMID: 19276254.

Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009 Apr;69(8):3382-3389. PubMed PMID: 19336570. PubMed Central PMCID: 2789401.

Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 2009 Jun;7(6):e1000121. PubMed PMID: 19492080. PubMed Central PMCID: 2683567.

Ginestier C, Liu S, Wicha MS. Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell 2009 Sep;5(3):229-230. PubMed PMID: 19733528.

Wicha MS. Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. Breast Cancer Res 2009;11(5):108. PubMed PMID: 19804613. PubMed Central PMCID: 2790845.

Ginestier C, Wicinski J, Cervera N, Monville F, Finetti P, Bertucci F, Wicha MS, Birnbaum D, Charafe-Jauffret E. Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle 2009 Oct;8(20):3297-3302. PubMed PMID: 19806016. PubMed Central PMCID: 2861502.

Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG. An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin. Cancer Res 2009 Oct;15(20):6386-6390. PubMed PMID: 19808871. PubMed Central PMCID: 2787085

Gur D, Liu S, Shukla A, Pero SC, Wicha MS, Krag DN. Identification of single chain antibodies to breast cancer stem cells using phage display. Biotechnol. Prog 2009 Dec;25(6):1780-1787. PubMed PMID: 19899107.

Wicha MS. Targeting breast cancer stem cells. Breast 2009 Oct;18 Suppl 3:S56-58. PubMed PMID: 19914544.


Eliane J-P, Repollet M, Luker KE, Brown M, Rae JM, Dontu G, et al. Monitoring serial changes in circulating human breast cancer cells in murine xenograft models. Cancer Res. 2008 Jul 15;68(14):5529–32. PubMed PMID: 18632603. PubMed Central: PMC2789403.

Charafe-Jauffret E, Monville F, Ginestier C, Dontu G, Birnbaum D, Wicha MS. Cancer stem cells in breast: current opinion and future challenges. Pathobiology 2008;75(2):75-84. PubMed PMID: 18544962. PubMed Central PMCID: 2789397.

Wicha MS. Cancer stem cell heterogeneity in hereditary breast cancer. Breast Cancer Res 2008;10(2):105. PubMed PMID: 18423071. PubMed Central PMCID: 2397530.

Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, Dontu G, Wicha MS. BRCA1 regulates human mammary stem/progenitor cell fate. Proc. Natl. Acad. Sci. U.S.A 2008 Feb;105(5):1680-1685. PubMed PMID: 18230721. PubMed Central PMCID: 2234204.

Boman BM, Wicha MS. Cancer stem cells: a step toward the cure. J. Clin. Oncol 2008 Jun;26(17):2795-2799. PubMed PMID: 18539956.

Kakarala M, Wicha MS. Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J. Clin. Oncol 2008 Jun;26(17):2813-2820. PubMed PMID: 18539959. PubMed Central PMCID: 2789399.

Korkaya H, Paulson A, Iovino F, Wicha MS. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008 Oct;27(47):6120-6130. PubMed PMID: 18591932. PubMed Central PMCID: 2602947.

Huang EH, Wicha MS. Colon cancer stem cells: implications for prevention and therapy. Trends Mol Med 2008 Nov;14(11):503-509. PubMed PMID: 18929507. PubMed Central PMCID: 2789402.

Charafe-Jauffret E, Ginestier C, Monville F, Wicinski J, Bertucci F, Viens P, Xerri L, Cabaud O, Dontu G, Wicha MS, Birnbaum D. [Stem cells and epithelial cancers: the example of breast cancer]. Ann Pathol 2008 Nov;28 Spec No 1(1):S30-32. PubMed PMID: 18984292.


Boman BM, Wicha MS, Fields JZ, Runquist OA. Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approaches. Clin. Pharmacol. Ther 2007 Jun;81(6):893-898. PubMed PMID: 17460605.

Ginestier C, Wicha MS. Mammary stem cell number as a determinate of breast cancer risk. Breast Cancer Res 2007;9(4):109. PubMed PMID: 17688678.

Wicha MS. Breast cancer stem cells: the other side of the story. Stem Cell Rev 2007 Jun;3(2):110-112; discussion 113. PubMed PMID: 17873342.

Ashkenazi R, Jackson TL, Dontu G, Wicha MS. Breast cancer stem cells-research opportunities utilizing mathematical modeling. Stem Cell Rev 2007 Jun;3(2):176-182. PubMed PMID: 17873350.

Korkaya H, Wicha MS. Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs 2007;21(5):299-310. PubMed PMID: 17896836.

Kakarala M, Wicha MS. Cancer stem cells: implications for cancer treatment and prevention. Cancer J 2007 Oct;13(5):271-275. PubMed PMID: 17921723.

Ginestier C, Korkaya H, Dontu G, Birnbaum D, Wicha MS, Charafe-Jauffret E. [The cancer stem cell: the breast cancer driver]. Med Sci (Paris) 2007 Dec;23(12):1133-1139. PubMed PMID: 18154716.

** Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007 Nov;1(5):555-567. PubMed PMID: 18371393. PubMed Central PMCID: 2423808.
** Top 10 most highly cited Cell Stem Cell articles from 2007 - 2012:


Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea--a paradigm shift. Cancer Res 2006 Feb;66(4):1883-1890; discussion 1895-1896. PubMed PMID: 16488983.

Liu S, Dontu G, Mantle ID, Patel S, Ahn N, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006 Jun;66(12):6063-6071. PubMed PMID: 16778178.

Wicha MS. Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis. Breast Cancer Res 2006;8(5):109. PubMed PMID: 16934104. PubMed Central PMCID: 1779494.

Wicha MS. Cancer stem cells and metastasis: lethal seeds. Clin. Cancer Res 2006 Oct;12(19):5606-5607. PubMed PMID: 17020960.


Dontu G, Wicha MS. Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia 2005 Jan;10(1):75-86. PubMed PMID: 15886888.

Liu S, Dontu G, Wicha MS. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7(3):86-95. PubMed PMID: 15987436. PubMed Central PMCID: 1143566.

Dontu G, Liu S, Wicha MS. Stem cells in mammary development and carcinogenesis: implications for prevention and treatment. Stem Cell Rev 2005;1(3):207-213. PubMed PMID: 17142857.


Dontu G, El-Ashry D, Wicha MS. Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol. Metab 2004 Jul;15(5):193-197. PubMed PMID: 15223047.

Spahlinger DA, Pai C, Waldinger MB, Billi JE, Wicha MS. New organizational and funds flow models for an academic cancer center. Acad Med 2004 Jul;79(7):623-627. PubMed PMID: 15234911.

Dontu G, Jackson KW, McNicholas E, Kawamura MJ, Abdallah WM, Wicha MS. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 2004;6(6):R605-615. PubMed PMID: 15535842. PubMed Central PMCID: 1064073.


Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A 2003 Apr;100(7):3983-3988. PubMed PMID: 12629218. PubMed Central PMCID: 153034.

Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003 May;17(10):1253-1270. PubMed PMID: 12756227. PubMed Central PMCID: 196056.

Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS. Stem cells in normal breast development and breast cancer. Cell Prolif 2003 Oct;36 Suppl 1:59-72. PubMed PMID: 14521516.


Sumantran VN, Zhang R, Lee DS, Wicha MS. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Cancer Epidemiol. Biomarkers Prev 2000 Mar;9(3):257-263. PubMed PMID: 10750663.

Sumantran VN, Lee DS, Baker VV, Murray S, Strawderman M, Wicha MS. A bcl-x(S) adenovirus demonstrates therapeutic efficacy in an ascites model of human breast cancer. J. Soc. Gynecol. Investig 2000 Jun;7(3):184-189. PubMed PMID: 10865187.

Bennett CL, Stinson TJ, Vogel V, Robertson L, Leedy D, O'Brien P, Hobbs J, Sutton T, Ruckdeschel JC, Chirikos TN, Weiner RS, Ramsey MM, Wicha MS. Evaluating the financial impact of clinical trials in oncology: results from a pilot study from the Association of American Cancer Institutes/Northwestern University clinical trials costs and charges project. J. Clin. Oncol 2000 Aug;18(15):2805-2810. PubMed PMID: 10920127.

Sumantran VN, Lee DS, Woods Ignatoski KM, Ethier SP, Wicha MS. A bcl-xS adenovirus selectively induces apoptosis in transformed cells compared to normal mammary cells. Neoplasia 2000 Jun;2(3):251-260. PubMed PMID: 10935511. PubMed Central PMCID: 1507566.

Hernandez-Alcoceba R, Pihalja M, Wicha MS, Clarke MF. A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors. Hum. Gene Ther 2000 Sep;11(14):2009-2024. PubMed PMID: 11020800.