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Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K, Eberhart CG. Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells. International Journal of Cancer. Mar 1;138(5):1246-55, 2016. PMID: 26422827; PMCID: PMC4772139.
Nie S, Gurrea M, Zhu J, Thakolwiboon S, Heth JA, Muraszko KM, Fan X*, Lubman DM*. Tenascin-C: A Novel Candidate Marker for Cancer Stem Cells in Glioblastoma Identified by Tissue Microarrays. Journal of Proteome Research, Feb 6;14(2):814-22, 2015 (*: Corresponding Author).
Lim KJ, Brandt WD, Heth JA, Muraszko KM, Fan X, Bar EE, and Eberhart CG. Lateral inhibition of Notch signaling in neoplastic cells. Oncotarget, Jan 30;6(3):1666-77, 2015.
Baxter PA, Li Q, Mao H, Kogiso M, Zhao X, Liu Z, Huang Y, Voicu H, Gurusiddappa S, Su JM, Adesina AM, Perlaky L, Dauser RC, Leung HE, Muraszko KM, Heth JA, Fan X, Lau CC, Man TK, Chintagumpala M, and Li XN. Silencing BMI1 Eliminates Tumor Formation of Pediatric Glioma CD133+ Cells Not by Affecting Known Targets But by Down-regulating a Novel Set of Core Genes. Acta Neuropathologica Communications, Dec 20;2:160. 2014.
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Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc A, Garzia L, Peacock J, Mack S, Wu X, Rolider A, Morrissy S, Cavalli F, Jones DT, Zitterbart K, Faria CC, Schuller U, Kren L, Kumabe T, Tominaga T, Ra YS, Garami M, Hauser P, Chan JA, Robinson S, Bogn‡r L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, Iolascon A, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Cho B, Kim S, Wang K, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho Y, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Delattre O, Doz FF, Reynaud SS, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD. Cytogenetic Prognostication within Medulloblastoma Subgroups. Journal of Clinical Oncology, [Epub ahead of print], Feb 18, 2014.
Hervey-Jumper SL, Altshuler DB, Wang AC, He X, Maher CO, Robertson PL, Garton HJ, Fan X, Muraszko KM, Camelo-Piragua S. The Role of CD133+ Cells in a Recurrent Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR). Brain Pathology, Jan;24(1):45-51, 2014.
He J, Liu Y, Zhu J, Wu J, Nie S, Heth JA, Muraszko KM, Fan X, and Lubman DM. Immunohistochemical Staining, Laser Capture Microdissection and FASP Assisted Proteomic Analysis of Target Cell Populations within Tissue Samples. Electrophoresis, Jun;34(11):1627-36, 2013.
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He J, Liu Y, Zhu T, Zhu J, Dimeco F, Vescovi AL, Heth JA, Muraszko KM, Fan X*, Lubman DM*. CD90 is identified as a marker for cancer stem cells in primary high-grade gliomas using tissue microarrays. Molecular and Cellular Proteomics, Jun;11(6):M111.010744, 2012. (*: Corresponding Author).
Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, He X, Hervey-Jumper SL, Heth JA, Muraszko KM, DiMeco F, Vescovi AL, and Fan X*. Endothelial cells create a stem cell niche in glioblastoma by providing Notch ligands that nurture self-renewal of cancer stem-like cells. Cancer Research, Sep 15;71(18):6061-72, 2011. (*: Corresponding Author).
Dai L, He J, Liu Y, Byun J, Vivekanandan A, Pennathur S, Fan X*, Lubman DM*. Dose-dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with gamma-secretase inhibitor. Proteomics. Dec;11(23):4529-40, 2011. (*: Corresponding Author).
Dai L, Liu Y, He J, Flack CG, Talsma CE, Crowley JG, Muraszko KM, Fan X*, Lubman DM. Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with gamma-secretase inhibitor. Proteomics. Oct;11(20):4021-8, 2011. (*: Corresponding Author).
Enguita-German M, Gurrea M, Schiapparellia P, Zhu TS, Crowley JG, Hamm LL, Costello MA, He X, Talsma CE, Flack CG, Hervey-Jumper SL, Heth JA, Muraszko KM, Rey JA, Fan X*, and Javier S. Castresana*. KIT expression and methylation in medulloblastoma and PNET cell lines and tumors. Journal of Neuro-Oncology, Jun;103(2):247-53, 2011. (*: Corresponding Author).
Shahi MH, Afzal M, Sinha S, Eberhart CG, Rey JA, Fan X, and Castresana JS. Human Hedgehog Interacting protein (HHIP) expression and promoter methylation in medulloblastoma cell lines and primary tumor samples. Journal of Neuro-Oncology, Jun;103(2):287-96, 2011.
He J, Liu Y, Zhu TS, Xie X, Costello MA, Talsma CE, Flack CG, Crowley JG, DiMeco F, Vescovi AL, Fan X*, and Lubman DM*. Glycoproteomic Analysis of Glioblastoma Stem Cell Differentiation. Journal of Proteome Research, Jan 7;10(1):330-338, 2011 (*: Corresponding Author).
Shahi MH, Afzal M, Sinha S, Eberhart CG, Rey JA, Fan X, and Castresana JS. Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in major brain tumors. BMC Cancer, Nov 8;10:614, 2010.
He J, Liu Y, Xie X, Zhu T, Soules M, DiMeco F, Vescovi AL, Fan X*, and Lubman DM*. Identification of cell surface glycoprotein markers for glioblastoma-derived stem-like cells using a lectin microarray and LC-MS/MS approach. Journal of Proteome Research, May 7;9(5):2565-72, 2010. (*: Corresponding Author).
Fan X*, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J, Nikkhah G, DiMeco F, Piccirillo S, Vescovi AL, Eberhart CG. Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts. Stem Cells, Jan;28(1):5-16, 2010. (*: Corresponding Author).
Mullendore ME, Koorstra J, Li YM, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG, Maitra A, Feldmann G. Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clinical Cancer Research, Apr 1;15(7):2291-301, 2009.
Li Y, Fan X, Goodwin CR, Laterra J, Xia S. Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5. BMC Cancer, Nov 7;8(1):325, 2008.
Fan X*, Eberhart CG*. Medulloblastoma Stem Cells. Journal of Clinical Oncology, (Invited Review), Jun 10;26(17):2821-7, 2008. (*: Corresponding Author).
Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. EGFR and notch pathways participate in the tumor suppressor function of gamma -secretase. Journal of Biological Chemistry, Nov 2;282(44):32264-73, 2007.
Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Vescovi AL, Piccirillo S, Dimeco F, Olivi A, Eberhart CG. Growth Inhibition of GBM and Glioma-Associated Cancer Stem Cells by Cyclopamine. Stem Cells, Oct;25(10):2524-33, 2007.
Dang L, Fan X (co-first author), Chaudhry A, Wang M, Gaiano N, Eberhart CG. Notch3 Signaling Initiates Choroid Plexus Tumor Formation. Oncogene, Jan 19;25(3):487-91, 2006.
Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, Eberhart CG. Notch Pathway Inhibition Depletes Stem-Like Cells and Blocks Engraftment in Embryonal Brain Tumors. Cancer Research, August 1; 66(15):7445-52, 2006.
Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner EB, Eberhart C, Laterra J, Abounader R. The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy. Cancer Research, Oct 15; 65(20):9355-62, 2005.
Inda MM, Perot C, Guillaud-Bataille M, Danglot G, Rey JA, Bello MJ, Fan X, Eberhart C, Zazpe I, Portillo E, Tunon T, Martinez-Penuela JM, Bernheim A, Castresana JS. Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous system. Histopathology, Dec; 47(6):631-7, 2005.
Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D, Brat DJ, Perry A, Eberhart CG. Notch1 and Notch2 have opposite effects on embryonal brain tumor growth. Cancer Research, Nov 1;64 (21):7787-93, 2004. (Featured on cover).
Fan X, Wang Y, Kratz J, Brat DJ, Robitaille Y, Moghrabi A, Perlman EJ, Dang CV, Burger PC, Eberhart CG. hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. American Journal of Pathology, Jun;162 (6):1763-9, 2003.
Inda MM, Fan X, Munoz J, Perot C, Fauvet D, Danglot G, Palacio A, Madero P, Zazpe I, Portillo E, Tunon T, Martinez-Penuela JM, Alfaro J, Eiras J, Bernheim A, Castresana JS. Chromosomal abnormalities in human glioblastomas: gain in chromosome 7p correlating with loss in chromosome 10q. Molecular Carcinogenesis, Jan;36(1):6-14, 2003.
Fan X, Aalto Y, Sanko SG, Knuutila S, Klatzmann D, Castresana JS. Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas. International Journal of Oncology, Nov;21(5):1141-50, 2002.
Fan X, Munoz J, Sanko SG, Castresana JS. PTEN, DMBT1, and p16 alterations in diffusely infiltrating astrocytomas. International Journal of Oncology, Sep;21(3):667-74, 2002.
Mercapide J, Zhang SY, Fan X, Furio-Bacete V, Schneider J, Lopez de la Osa I, Patchefsky AS, Klein-Szanto AJ, Castresana JS. CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast. Molecular Carcinogenesis, Sep;35(1):6-12, 2002.
Fan X, Inda MM, Tunon T, Castresana JS. Improvement of the methylation specific PCR technical conditions for the detection of p16 promoter hypermethylation in small amounts of tumor DNA. Oncology Reports, 9(1):181-3, 2002.
Fan X, Paetau A, Aalto Y, Valimaki M, Sane T, Poranen A, Castresana JS, Knuutila S. Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas. Cancer Genetics and Cytogenetics, 15;128(2):97-103, 2001.
Fan X, Furnari FB, Cavenee WK, Castresana JS. Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells. International Journal of Oncology, 18(5):1023-6, 2001.
Fan X, Gomez L, Sierrasesumaga L, Nistal M, Castresana JS. Lack of gene amplification as a mechanism of CDK4 activation in human neuroblastoma. Oncology Reports, 6(3):647-650,1999.
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