The graphic on the previous page show that immunization with HAV vaccine induces antibody levels that far exceed those obtained by passive immunization with immune serum globulin. We know that the antibodies in serum globulin protect against clinical hepatitis. How would you determine whether the vaccine will protect humans against clinical hepatitis A?
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| A. | Vaccinate monkeys, and then inoculate them with hepatitis A virus. |
| B. | Vaccinate people, and then check their antibodies for viral neutralizing activity in an in vitro assay of viral infectivity. |
| C. | Vaccinate groups of people with either HAV or HBV vaccine, then wait to see which group gets the most hepatitis A. |
| D. | None of the above. |
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