Randall K Ten Haken, PhD
Professor and Director of Physics Division
Randall K. Ten Haken, PhD:
Professor and Director of Physics Division
Randall K. Ten Haken, Ph.D., is the Director of the Physics Division within the Department of Radiation Oncology. He is a tenured Professor and serves as an Associate Departmental Chair. He is a Fellow of the American Association of Physicists in Medicine (FAAPM), a Fellow of the Institute of Physics (FInstP), a Fellow of the American Society for Radiation Oncology (FASTRO), and a Fellow of the American College of Radiology (FACR). He is also the Principal Investigator/Program Director of a long-standing program project grant related to the Optimization of High Dose Conformal Therapy. The overall goal of that program project is to improve the effectiveness of radiation therapy for cancer patients by individualizing therapy beyond simple anatomy. Specifically, we seek to use both anatomical and physiological information acquired during treatment to re-optimize therapy based on the individual patient’s treatment history and response.
Over the past quarter century, Randy Ten Haken has directed the efforts of numerous graduate students, postdoctoral fellows, and medical residents during their research years. He has published numerous articles on geometric and dosimetric uncertainties in patient treatments. He has developed novel iso-toxicity based treatment approaches for radiotherapy dose escalation and published extensively on assessing and modeling treatment outcomes. He recently served as co-guest editor for a special supplement of the International Journal of Radiation Oncology Biology and Physics dedicated to the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC). He couples this background and expertise with investigational leadership and collaborative skills to help combine the physics and clinical outcomes research aspects of many complex projects. In collaboration with his colleagues within the department as well as others throughout the University of Michigan, his research currently focuses primarily on the investigation of patient-based adaptive techniques and outcomes assessments using physiological imaging for use in optimization of treatment techniques. This investigation of “response-based” optimization of adaptive therapy is one of the core focuses of the Physics Division.
Other Experience and Professional Memberships
B.Sc - Applied Mathematics Engineering & Physics, Univ. of Wisconsin, Madison, WI
Key Publications (selected from 170)
Ten Haken RK, Nussbaum GH, Emami B, Hughes WL: Photon activation - 150 decay studies of tumor blood flow. Med Phys 8:324-336, 1981.
Ten Haken RK, Awschalom M, Rosenberg I: The use of non-hydrogenous wedges for therapeutic neutron beam shaping. Med Phys 9:204-207, 1982.
Ten Haken RK, Awschalom M, Rosenberg I: Activation for the major constituents of tissue and air by a fast neutron therapy beam. Med Phys 10:636-641, 1983.
Ten Haken RK, Awschalom M, Rosenberg I: Absolute neutron dosimetry: Effects of ionization chamber wall thickness. Med Phys 12:46-52, 1985.
Ten Haken RK, Fraass BA: Determination of electron beam mean incident energy from d50(Ionization) values. Med Phys 14:985-991, 1987.
Ten Haken RK, Diaz R, McShan DL, Fraass BA, Taren J, Hood TW: From manual to computerized planning for 125-I stereotactic brain implants. Int J Radiat Oncol Biol Phys 15:467-480, 1988.
Ten Haken RK, Perez-Tamayo C, Tesser R, McShan D, Fraass B, Lichter AS: Boost treatment of the prostate using shaped, fixed fields. Int J Radiat Oncol Biol Phys 16:193-200, 1989.
Lawrence TS, Tesser RJ, Ten Haken RK: Application of dose volume histograms to treatment of intrahepatic malignancies with radiation. Int J Radiat Oncol Biol Phys 19:1041-1047, 1990.
Ten Haken RK, Forman JD, Heimburger DK, Gerhardsson A, McShan DL, Perez-Tamayo C, Schoeppel SL, Lichter AS: Treatment planning issues related to prostate movement in response to differential filling of the rectum and bladder. Int J Radiat Oncol Biol Phys 20:1317-1324, 1991.
Ten Haken RK, Thornton AF, Sandler HM, LaVigne ML, Quint DJ, Fraass BA, Kessler ML, McShan DL: A quantitative assessment of the addition of MRI to CT-based, 3-D treatment planning of brain tumors. Radiother Oncol 25:121-133, 1992.
Ten Haken RK, Martel MK, Kessler ML, Hazuka MB, Lawrence TS, Robertson JM, Turrisi AT, Lichter AS: Use of Veff and iso-NTCP in the implementation of dose escalation protocols. Int J Radiat Oncol Biol Phys 27:689-695, 1993.
Kessler ML, Ten Haken RK, Fraass BA, and McShan DL: Expanding the use and effectiveness of dose-volume histograms for 3-D treatment planning I: integration of 3-D dose-display. Int J Radiat Oncol Biol Phys 29:1125-1131, 1994.
Balter JM, Lam KL, Sandler HM, Littles JF, Bree RL, Ten Haken RK: Automated localization of the prostate at the time of treatment using radiopaque markers: technical feasibility. Int J Radiat Oncol Biol Phys 33:1281-1286, 1995.
Balter JM, Ten Haken RK, Lawrence TS, Lam KL, Robertson JM: Uncertainties in CT-based treatment plans due to patient breathing. Int J Radiat Oncol Biol Phys 36:167-174, 1996.
Robertson JM, Ten Haken RK, Hazuka MB, Turrisi AT, Martel MK, Pu AT, Littles JF, Martinez FJ, Francis IR, Quint LE, Lichter AS: Dose escalation for non-small cell lung cancer using conformal radiation therapy. Int J Radiat Oncol Biol Phys. 37:1079-1085, 1997.
McGinn CJ, Ten Haken RK, Ensminger WD, Walker S, Wang S, Lawrence TS: The treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model. J Clin Oncol 16:2246-2252, 1998.
Ten Haken RK, Fraass BA, Lichter AS, Marsh LH, Radany EH, Sandler HM: A brain tumor dose escalation protocol based on effective dose equivalence to prior experience. Int J Radiat Oncol Biol Phys 42:137-141, 1998.
Eisbruch A, Ten Haken RK, Kim HM, Marsh LH, Ship JA: Dose, volume and function relationships in parotid salivary glands following conformal and intensity modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys 45:577-587, 1999.
Lujan AE, Larsen EW, Balter JM, Ten Haken RK: A method for incorporating organ motion due to breathing into 3D dose calculations. Med Phys 26:715-720, 1999.
Balter, JM, Dawson LA, Kazanjian S, McGinn C, Brock KK, Lawrence T, Ten Haken R: Determination of ventilatory liver movement via radiographic evaluation of diaphragm position. Int J Radiat Oncol Biol Phys 51:267-270, 2001.
Dawson LA, Normolle D, Balter J, McGinn C, Lawrence TS, Ten Haken RK: Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 53:810-821, 2002.
Rosu M, Dawson LA, Balter JM, McShan DL, Lawrence TS, Ten Haken RK: Alterations in normal liver doses due to organ motion. Int J Radiat Oncol Biol Phys 57:1472-1479, 2003.
Chetty IJ, Rosu M, McShan DL, Fraass BA, Balter JM, Ten Haken RK: Accounting for center-of-mass target motion using convolution methods in Monte Carlo-based dose calculations of the lung. Med Phys 31:925-932, 2004.
Dawson LA, Biersack M, Lockwood G, Eisbruch A, Lawrence TS, Ten Haken RK: Use of principal component analysis to evaluate the partial organ tolerance of normal tissues to radiation. Int J Radiat Oncol Biol Phys 62:829-837, 2005.
Lam KL, Ten Haken RK, Litzenberg DW, Balter JM, Pollock SM: An application of Bayesian statistical methods to adaptive radiotherapy. Phys Med Biol 50:3849-3858, 2005.
Thomas E, Chapet O, Kessler ML, Lawrence TS, Ten Haken RK: The benefit of using biological parameters (EUD and NTCP) in IMRT optimization for the treatment of intrahepatic tumors. Int J Radiat Oncol Biol Phys 62:571-578, 2005.
Chapet O, Thomas E, Kessler ML, Fraass BA, Ten Haken RK: Esophagus sparing with IMRT in lung tumor irradiation, an EUD-based optimization technique. Int J Radiat Oncol Biol Phys 63:179-187, 2005.
Johnson T, Taylor J, Ten Haken RK, Eisbruch A: A Bayesian mixture model relating dose to critical organs and functional complication in 3D conformal radiation therapy. Biostatistics 6:615-632, 2005.
Sir MY, Pollock SM, Epelman MA, Lam KL, Ten Haken RK: Ideal spatial radiotherapy dose distributions subject to positional uncertainties. Phys Med Biol 51: 6329–6347, 2006.
Spalding AC, Jee K-W, Vineberg K, Jablonowski M, Fraass BA, Pan CC, Lawrence TS, Ten Haken RK, Ben-Josef E: The potential for dose-escalation and reduction of risk using IMRT optimization with lexicographic ordering and gEUD-based cost functions. Med Phys 34:521-529, 2007.
Tsien C, Gomez-Hassan D, Chenevert TL, Lee J, Lawrence TS, Ten Haken RK, Junck LR, Ross B, Cao Y: Predicting outcome of patients with high grade gliomas after radiotherapy using quantitative analysis of T1-weighted magnetic resonance imaging. Int J Radiat Oncol Biol Phys 67:1476-1483, 2007.
Rosu M, Chetty IJ, Tatro DS, Ten Haken RK: The impact of breathing motion versus heterogeneity effects in lung cancer treatment planning. Med Phys 34:1462-1473, 2007.
Kong F-M, Frey KA, Quint LE, Ten Haken RK, Kessler ML, Hayman JA, Chetty IJ, Normolle D, Eisbruch A, Lawrence TS: A pilot study of [18F]Fluorodeoxyglucose positron emission tomography scans during and after radiation based therapy in patients with non-small cell lung cancer. J Clin Oncol 25:3116-3123, 2007.
Lam KL, Balter JM, Ten Haken RK: Effect of daily localization and correction on setup uncertainty: dependences on measurement uncertainty, re-positioning uncertainty and action level. Phys Med Biol 52: 6575–6587, 2007.
Cao Y, Pan C, Balter JM, Platt JF, Francis IR, Knol JA, Normolle D, Ben-Josef E, Ten Haken RK, Lawrence TS: Liver function after irradiation based upon computed tomographic portal vein perfusion imaging. Int J Radiat Oncol Biol Phys 70:154-160, 2008. PMCID: PMC2714771
Lee I, Piert M, Gomez-Hassan D, Junck L, Rogers L, Hayman J, Ten Haken RK, Lawrence TS, Cao Y, Tsien C. Association of 11C-Methionine PET uptake with site of failure after concurrent temozolomide and radiation for primary glioblastoma multiforme. Int J Radiat Oncol Biol Phys 73:479-485, 2009. (PMCID2652133)
Feng M, Kong F-M, Gross M, Fernando S, Hayman JA, Ten Haken RK: Using fluorodeoxyglucose positron emission tomography to assess tumor volume during radiotherapy for non-small cell lung cancer and its potential impact on adaptive dose escalation and normal tissue sparing. Int J Radiat Oncol Biol Phys 73:1228-1234, 2009.
Jin J-Y, Kong F-M, Chetty IJ, Ajlouni M, Ryu S, Ten Haken R, Movsas B. Impact of fraction size on lung radiation toxicity: hypofractionation may be beneficial in dose escalation of radiotherapy for lung cancers. Int J Radiat Oncol Biol Phys 76:782-788, 2010.
Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB, Ten Haken RK, Yorke ED. Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys 76:S3-S9, 2010.
Marks LB, Yorke ED, Jackson A, Ten Haken RK, Constine LS, Eisbruch A, Bentzen S, Nam J, Deasy JO. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys 76:S10-S19, 2010.
Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, Ten Haken RK. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys 76:S94-S100, 2010.
Kavanagh BD, Pan CC, Dawson LA, Das SK, Li XA, Ten Haken RK, Miften M. Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol Biol Phys 76:S101-S107, 2010.
Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TE. Radiation-associated kidney injury. Int J Radiat Oncol Biol Phys 76:S108-S115, 2010.
Jeraj R, Cao Y, Ten Haken RK, Hahn C, Marks L. Imaging for assessment of radiation-induced normal tissue effects. Int J Radiat Oncol Biol Phys 76:S140-S144, 2010. PMCID: PMC2843154
Deasy JO, Bentzen SM, Jackson A, Ten Haken RK, Yorke ED, Constine LS, Sharma A, Marks LB. Improving normal tissue complication probability models: the need to adopt a “data-pooling” culture. Int J Radiat Oncol Biol Phys 76:S151-S154, 2010. PMCID: PMC2854162
Jackson A, Marks LB, Bentzen SM, Eisbruch A, Yorke ED, Ten Haken RK, Constine LS, Deasy JO. The lessons of QUANTEC: recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome. Int J Radiat Oncol Biol Phys 76:S155-S160, 2010.
Houweling AC, Philippens MEP, Dijkema T, Roesink JM, Terhaard CHJ, Schilstra C, Ten Haken RK, Eisbruch A, Raaijmakers CPJ. A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 76:1259-1265, 2010.
Dijkema T, Raaijmakers CPJ, Ten Haken RK, Roesink JM, Braam PM, Houweling AC, Moerland MA, Eisbruch A, Terhaard CHJ. Parotid gland function after radiotherapy: the combined Michigan and Utrecht experience. Int J Radiat Oncol Biol Phys 78:449-453, 2010.
Yuan S, Frey KA, Gross MD, Hayman JA, Arenberg D, Curtis J, Cai X-W, Ramnath N, Kalemkerian GP, Ten Haken RK, Eisbruch A, Kong F-M: Semiquantification and classification of local pulmonary function by V/Q SPECT in patients with non-small cell lung cancer: potential indication for radiotherapy planning J Thorac Oncol 6:71-78, 2011.
Eisbruch A, Kim HM, Feng FY, Lyden TH, Haxer MJ, Feng M, Worden FP, Bradford CR, Prince ME, Moyer JS, Wolf GT, Chepeha DB, Ten Haken RK: Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates. Int J Radiat Oncol Biol Phys, 81:e93-e99, 2011.
Tsien CI, Brown D, Normolle D, Schipper M, Piert M, Junck L, Heth JA, Gomez-Hassan D, Ten Haken RK, Chenevert TL, Cao Y, Lawrence TS: Concurrent temozolomide and dose-escalated intensity modulated radiation therapy in newly diagnosed glioblastoma. Clin Cancer Res 18:273-279, 2012.
Yuan S, Frey KA, Gross MD, Hayman JA, Arenberg D, Cai X-W, Ramnath N, Hassan KH, Moran J, Eisbruch A, Ten Haken RK, Kong F-M: Changes in global function and regional ventilation and perfusion on SPECT during the course of radiotherapy in patients with non-small cell lung cancer. Int J Radiat Oncol Biol Phys 82:e631-e638, 2012.
Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A: Lhermitte sign after chemo-IMRT of head and neck cancer: incidence, doses, and potential mechanisms. Int J Radiat Oncol Biol Phys (In Press, Available online 26 January, 2012).
Cao Y, Wang H, Johnson TD, Pan C, Hussain H, Balter JM, Normolle D, Ben-Josef E, Ten Haken RK, Lawrence TS, Feng M: Prediction of liver function using MR-based portal venous perfusion imaging. Int J Radiat Oncol Biol Phys. (In Press, Available online 18 April, 2012).
Randall Ten Haken, PhD, Professor and Director of Physics Division
|University of Michigan Hospital and Health Systems
Department of Radiation Oncology
1500 East Medical Center Dr.
UH B2 C438, SPC 5010
Ann Arbor, MI 48109