University of Michigan Center for Gastrointestinal Research


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    2016 - 2017

    UMCGR Weekly Noon Conference

    1/11/16-Jeffery Perry, Ph.D. "Functional mapping of the Dengue virus genome by insertional mutagenesis and next generation sequencing"

    1/18/16-Andrew Shreiner, M.D. "Description of a clinical study on the impact of dietary FODMAPs on functional GI symptoms in Crohn's patients"

    1/25/16-John Kao, M.D. "Presenting National Meetings"

    2/1/16-Mo El-Zaatari, Ph.D. "Novel mechanisms mediating GI pre-neoplasia"

    2/8/16-Bishr Omary, M.D., Ph.D. "When is it time to tell your story & to which journal"

    02/15/16-Kate Walton, Ph.D. "Building Intestinal Villi"

    3/7/16-Melody Zeng, Ph.D. "Research Update"

    3/14/16-Rebecca Hughes, Ph.D. and Joe Austin, Ph.D. "IRB 101 Discussion"

    3/21/16-Chung Owyang, M.D. "Academic Skills Workshop Seminar titled "How to write a successful R01 Grant"

    3/28/16-Jason Spence, Ph.D. "Research Advice"

    4/11/16-Alana Chin, Ph.D. "β-catenin destruction complex-independent regulation of hippo-YAP signaling by APC in Intestinal Tumorigenesis"

    4/18/16-Andrea Wright, Ph.D. "Body Composition in Non-Alcoholic Fatty Liver Disease: An Analysis of the Framingham Heart Study"

    4/25/16-Daniel Triner, Ph.D. "Pro-Inflammatory HIF-2a/MAZ Signaling in Colitis and Colon Cancer"

    5/2/16-Graham Brady, M.D. "Role of nuclear lamins in liver disease"

    5/9/16-Heather Schofield, Ph.D. "Elucidating the Role of Bmi1 in Pancreatitis and the Initiation of Pancreatic Cancer"

    5/16/16-Kate Walton, Ph.D. "Defining the role of vasculature in villus morphogenesis"

    No weekly noon seminars for summer months June, July and August

    9/19/16-Heather Schofield, Ph.D. and Daniel Triner, Ph.D., (Research Updates) "New mouse model demonstrates the necessity of mutant p53 expression for pancreatic cancer progression" and "MAZ as a novel regulator of the proinflammatory response in colitis and colon cancer"

    9/26/16-Graham Brady, M.D., and Joseph Pickard Ph.D., (Research Updates) "Role of nuclear lamina in liver disease" and "Mechanisms of colonization resistance to enteric pathogens"

    10/3/16-Tina Morhardt, M.D., and Holly Turala, Ph.D., "IL-10 producing small intestinal macrophages has protective role in intestinal inflammation" and "Host and bacterial modulation of norovirus pathogenesis"

    10/10/16-Matthew Sturm, M.D. "Multiplexed molecular imaging of biliary intraepithelial neoplasia; imaging strategies for the early detection of cancer in indeterminate biliary strictures"

    10/17/16-Marina Pasca di Magliano, Ph.D., "Myeloid cells regulate Acinar cell plasticity and pancreatic remodeling in mice".

    10/24/16-Heather Schofield, Ph.D. " Journal Club"

    10/31/16-Jeffery Perry, Ph.D., "Investigation of Dengue Virus through Functional Mapping of Its Genome"

    11/7/16-Christiane Wobus, Ph.D., TBA

    11/14/16-Daniel Triner, Ph.D., TBA

    11/21/16-Eric Martens, Ph.D., TBA

    11/28/16-Graham Brady, M.D., TBA

    12/5/16-Juanita L. Merchant, M.D., Ph.D., Men1 Gastrinomas

    12/12/16-Yatrik Shah, Ph.D., TBA

    12/19/16-Linda Samuelson, Ph.D., TBA

    12/26/16- No Conference


    2016 Visiting Professor Seminars

    The UMCGR Visiting Professor Seminar Series has been temporarily suspended as the Center grant is on no-cost time extension currently.


    2016 Annual Academic Workshop and Retreat

    Friday February 12, 2016

    Presentations by T32 Trainees and Pilot Awardees in the Medical Science Building II Room 4234.
    Presenters: Melody Zeng, Ph.D., Graham Brady, M.D., Andrew Shreiner, M.D., Alana Chin, Ph.D., Heather Schofield,  Kate Walton, Ph.D., Daniel Triner, Nataliya Razumilava, M.D., Elise Demitrack, Ph.D., and Mary K. Estes, Ph.D.

    12:00 – 12:10 PM- Welcome by Chung Owyang, M.D.
    12:10 – 12:40 PM- Melody Zeng, Ph.D., Research Fellow, Department of Pathology, Medical School. "Gut microbiota-induced IgG in host defense"

    12:40 – 1:10 PM- Graham Brady, M.D., Ph.D., House Officer, Division of Gastroenterology, Internal Medicine, University of Michigan Hospitals. "Role of nuclear lamins in liver disease"

     1:10 – 1:40 PM- Andrew Shreiner, M.D., Clinical Lecturer in Internal Medicine, Division of Gastroenterology, Medical School.  "Introduction to a clinical study: Impact of dietary FODMAPs on functional GI symptoms, microbiota, and inflammation in Crohn's disease patients in remission"

     1:40 – 2:10 PM- Alana Chin, Ph.D. a Ph.D. Candidate, Cell and Developmental Biology, Medical School. "Temporal gradient of increasing Wnt/β-catenin signaling regulates normal intestine development"

     2:10 – 2:40 PM- Heather Schofield, Graduate Student Instructor, Cell and Developmental Biology, Medical School.  "A New Mouse Model Demonstrates the Necessity of Mutant p53 Expression for Pancreatic Cancer Progression"

     2:50 – 3:20 PM- Kate Walton, Ph.D., Research Investigator, Cell and Developmental Biology, Medical School.  "Defining the requirement of vasculature in villus development: modified Notch signaling alters vascular pattern and villus growth"

     3:20 – 3:50 PM- Daniel Triner, Graduate Student Instructor, Molecular and Integrative Physiology, Medical School. "Pro-Inflammatory MAZ in Colitis & Colon Cancer"

     3:50 – 4:20 PM- Nataliya Razumilava, M.D., Clinical Lecturer, Division of Gastroenterology, Internal Medicine, University of Michigan Hospitals. "Hh signaling facilitates metaplastic transformation of the biliary tract"

     4:20 – 4:50 PM- Elise Demitrack, Ph.D., Research Investigator, Molecular and Integrative Physiology, Medical School. "Notch/mTORC1 regulation of gastric stem cells during homeostasis and disease"   

     4:50 – 5:20 PM- Presentation by Mary K. Estes, Ph.D., Professor, Virology & Microbiology, Baylor College of Medicine, Houston, TX, as our key note speaker and fourth year Yamada Lectureship honoree. "Follow the P's: Passion, Persistence, Prepare, Pick your Battles"

    Saturday, February 13, 2016 (Retreat Keynote Speaker)

    Mary K. Estes, Ph.D., Professor, Virology & Microbiology, Baylor College of Medicine, Houston, Texas. Her research is in human mini-gut cultures to understand gastrointestinal virus-host interactions and mechanisms of pathogenesis and immunity. Topic: Understanding Human Noroviruses. 10:00-11:00 AM, Michigan League, Hussey Room on the second floor. Hosted by The Michigan Center for Gastrointestinal Research.


    2016 Midwest DDRCC Academic Workshop- Mayo Clinic June 3-4th

    Friday June 3rd

    Morning Session

    7:30-8:00- Continental Breakfast

    8:00-8:05- Welcome ― Nicholas LaRusso, M.D., Mayo Clinic

    8:05-9:00- Peter Perrin, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases, Working together to put the DDRCC program's mission into action

    9:00-10:00- P&F Presentations — Session 1: Microbiome

    Moderators — Bana Jabri, M.D., Ph.D., University of Chicago and Theresa Pizarro, Ph.D., Case Western Reserve University

    9:00-9:15- Nicole Koropatkin, Ph.D., University of Michigan, Competition and utilization of resistant starch among human gut bacteria

    9:15-9:30- Alexander Rodriguez-Palacios, D.V.M., D.V.Sc., Ph.D., Case Western Reserve University, Pathogenic gut microbiota from 3D-stereomicroscopic cavernous lesions in Crohn's disease

    9:30-9:45- Melody Zeng, Ph.D., University of Michigan, Role of gut microbiota- induced IgG in host defense

    9:45-10:00- Joe Pierre, Ph.D., University of Chicago, Experimental studies of a novel antimicrobial peptide regulator of fungal commensalism

    10:30-11:15- Jason Spence, Ph.D., University of Michigan, Organoids as models for GI biology and pathobiology

    11:15-12:00- Jorge Bezerra, M.D., Cincinnati Children's Hospital Medical Center, Rebuilding the biliary epithelium by immune cells

    12:00-1:00- Buffet Lunch

    Afternoon Session

    1:00-1:45- Keith Robertson, Ph.D., Mayo Clinic, Epigenetics and liver disease

    1:45-3:00- P&F Presentations — Session 2: Gut Inflammation and Enteric Neuroscience

    Moderators — Juanita Merchant, M.D., Ph.D., University of Michigan, and Fabio Cominelli, M.D., Ph.D., Case Western Reserve University

    1:45-2:00- Ganapati Mahabaleshwar, Ph.D., Case Western Reserve University,
    MyeloidKLF6: A critical regulator of chronic intestinal inflammation

    2:00-2:15- Arthur Beyder, M.D., Ph.D., Mayo Clinic, The molecular mechanisms of enterochromaffin cell function

    2:15-2:30- Maxime Mahe, Ph.D., Cincinnati Children's Hospital Medical Center, Generating a human gut with an enteric nervous system to understand neural influences on intestinal epithelium

    2:30-2:45- Blair Madison, Ph.D., Washington University, The Let-7 target PLAGL2 acts as an oncogene in colorectal cancer and cooperatively augments IGF2 expression in conjunction with IGF2BP2

    2:45-3:00- Ting Wen, Ph.D., Cincinnati Children's Hospital Medical Center, Analysis and function of human esophageal intraepithelial lymphocytes (IELs) in eosinophilic esophagitis (EoE)

    4:00-4:45- P&F Presentations — Session 3: Liver Part I

    Moderators — Jorge Bezerra, M.D., Cincinnati Children's Hospital Medical Center and Nicholas Davidson, M.D., D.Sc., Washington University

    4:00-4:15      Luis Batista, Ph.D., Washington University, Molecularand functionalanalysisofdisease-associatedtelomerasemutationsin liver biology

    4:15-4:30      Joel Schilling, M.D., Ph.D., Washington University, Macrophagemetabolismin the pathogenesis of non-alcoholic steatohepatitis

    4:30-4:45      Rory Smoot, M.D., Mayo Clinic, Dysregulated platelet derived growth factor and hippo signaling in cholangiocarcinoma

    Evening Session

    6:00-7:30       Dinner

    7:30-8:30       Career Development Pearls: How to be successful! — Panelists: Nicholas LaRusso, M.D., Gregory Gores, M.D., and Juanita Merchant, M.D., Ph.D.

    Saturday June 4th

    Mayo Clinic Gonda Building, Geffen Auditorium & Nathan Landow Atrium

    7:00-8:00- Networking Breakfast

    8:00-8:45- P&F Presentations — Session 4: Liver (Continued)
    Moderators — Aaron Zorn, Ph.D., Cincinnati Children's Hospital Medical Center and Nicholas LaRusso, M.D., Mayo Clinic
    8:00-8:15- Takuya Sakaguchi, Ph.D., Case Western Reserve University, Gain- of-function mutation in cmklr1, chemerin receptor, leads to NASH-like hepatic inflammation in zebrafish

    8:15-8:30- Chunyue Yin, Ph.D., Cincinnati Children's Hospital Medical Center, Modeling inherited childhood intrahepatic cholestasis using zebrafish

    8:30-8:45-Samar Ibrahim, M.B., Ch.B. Mayo Clinic, CXCL10-/- mice are protected against diet-induced non-alcoholic steatohepatitis

    8:45-9:45- Break & Mentoring Round Tables

    9:45-11:15- Panel Discussion: How toEnhanceCollaboration& Technology Transfer Among Midwest DDRCCs

    Moderator — Gregory Gores, M.D.

    Panelists: Juanita Merchant, M.D., Ph.D., Associate Director, University of Michigan; Jorge Bezerra, M.D., Director, Cincinnati Digestive Disease Health Center; Nicholas Davidson, M.D., Director, Washington University; Fabio Cominelli, M.D., Ph.D., Director, Case Western Reserve University; Nicholas LaRusso, M.D., Director, Mayo Clinic; and Peter Perrin, Ph.D., National Institute of Diabetes and Digestive and Kidney Disorders

    11:15-12:15- Poster Session/Buffet Lunch

    12:15- Adjourn


* Co-sponsored seminars


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