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Fall 2009 Newsletter

Message from the Director

The Administration Core coordinated the Michigan Diabetes Research and Training Center’s (MDRTC) application to NIDDK in response to the American Recovery and Reinvestment Act of 2009 (ARRA). We consulted core directors and users to determine how supplementary funds could best be used to accelerate the pace of scientific research. Each core requested equipment up to $100,000. We also requested additional funds to support pilot and feasibility studies in 2009 and 2010. The P/FS program has demonstrated an excellent return on investment, based on the number of publications and grants resulting from the initial work. We have already heard that we will be receiving $600,000 and will keep you appraised of additional funding.

I would like to thank you for responding to the MDRTC survey developed to measure satisfaction with the quality, timeliness and cost of the MDRTC cores. Fifty-seven of our 150 members (38%) responded to the survey. The results of the core survey will be used to enhance current services and determine future services.

I would also like to remind you of the importance of citing the MDRTC in your publications when you have used MDRTC core resources. NIDDK is using the number of research papers citing the grant to evaluate diabetes centers. A national Diabetes Centers website was established which automatically retrieves publications from PubMed Central that contain the Center grant number (see article below). Currently, less than one-third of the publications supported by the MDRTC actually cite the MDRTC grant number in the Acknowledgements. We need to improve our reporting.

The following language should be used to recognize the MDRTC in publications:
“This work utilized ______Core(s) of the Michigan Diabetes Research and Training Center funded by DK020572 from the National Institute of Diabetes and Digestive and Kidney Diseases.”
OR

“This work was funded by a Pilot and Feasibility Study from the Michigan Diabetes Research and Training Center (DK020572 from the National Institute of Diabetes and Digestive and Kidney Diseases).”

Best wishes,
Bill

MDRTC Core Updates

Animal Phenotyping Core

To make animal phenotyping easier for our investigators, we are now providing repeated measurements of energy expenditure, physical activity, body composition, body weight, and food consumption over time. We are also providing on-site animal breeding and housing to assist with studies of young animals. For details, please email Nathan Qi at nathanqi@med.umich.edu or call him at 734-764-7043.

Cell & Molecular Biology Core

The Cell & Molecular Biology Core is now providing subsidies for Next Generation DNA sequencing projects (e.g. ChIP-Seq studies) performed through the U-M DNA Sequencing Core. The project must have a clear connection to diabetes. A formal mechanism for the subsidies is not yet established. Please email Ron Koenig rkoenig@umich.edu for further information.

Biostatistics and Economic Modeling Core:
New Disease Modeling Tools and a new version of the Michigan Model for Diabetes

A new addition to the MDRTC website is Disease Modeling software which should be of use to disease modelers and researchers who did not previously have modeling tools available.
This is free software that can be downloaded under GPL license and allows simulation of diabetes disease progression. The user can create and modify disease models, include population covariates, define intervention rules, and apply cost and health utility estimates. The software includes a user Interface that simplifies the work.

This software was used to create a new and updated version of the Michigan Model for Diabetes. The new model was validated against published results from the United Kingdom Prospective Diabetes Study. This model is available as a file for download and after download can be used by the modeling software. The model is fully documented including the sources of information and results. Simulation results that validate the model against the UKPDS33 study are also available online.

The address of the web site is:
http://www.med.umich.edu/mdrtc/cores/DiseaseModel/

The new website contains videos that explain the method used for disease modeling and also contains an online user manual for using the software. Future improvements will be published online and include improving the model and the software. The current focus is on improving the estimates used to model retinopathy and tools to estimate model parameters using data from multiple studies.

Behavioral, Clinical and Health Systems (BCHS) Intervention Research Core

The most exciting development in the BCHS core is a new collaboration with El Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE) in Mexico. The health care of over 11 million government workers and their families is provided by ISSSTE. Like the VA system, ISSSTE has its own health care providers, hospitals, clinics and pharmacies. There are almost 900,000 patients in the ISSSTE system with diabetes (13.4% prevalence).

ISSSTE has made remarkable progress in improving diabetes care, and is in the process of converting its entire system to electronic medical records. They have set and are exceeding targets for the percent of ISSSTE patients with diabetes having an A1C of less than 7%. The targets for A1Cs less than 7% are 2008: 25%, 2009: 40%, 2010: 50%, 2011: 55%, and 2012: 60%. Currently they are well ahead of their target with 62% of their diabetic patients achieving A1C below 7% by April of 2009.

Their long range goal is to “Achieve patient-responsibility in managing their disease through a systematic process of empowerment, which avoids the complications and increases the quality of life of patients with diabetes and their families.” After studying the literature and meeting with Robert M. Anderson, EdD, Martha M. Funnell, MS, RN, CDE, and John D. Piette, PhD, ISSSTE decided to formally adopt patient empowerment as their system wide approach to diabetes care and education. They have asked the BCHS core to provide consultation, technical assistance, and training to help them achieve this laudable goal.

Early in October of 2009 ISSSTE will bring over 800 of their staff and providers to Mexico City for a three-day diabetes conference. Dr. Anderson and Ms. Funnell will provide the initial and ongoing training related to patient empowerment. Dr. Piette will provide training related to other aspects of diabetes care as well be in charge of evaluating how well ISSSTE integrates empowerment into the routine care it provides it patients.

NIH-Sponsored Medical Student Training Program for Summer 2009

The MDRTC participated in the Medical Student Research Program in Diabetes sponsored by the NIDDK. Four medical students from University of Illinois, Wayne State University and U of M conducted independent research under the direction of established MDRTC investigators. The mentors for this program included John A. Williams, MD, PhD, Molecular & Integrative Physiology, Caroline Richardson, MD, Family Medicine, Amy Rothberg, MD, Internal Medicine, Metabolism, Endocrinology and Diabetes, and Peter Dempsey, PhD, Pediatrics and Communicable Diseases.

The objectives of this program were to provide students the opportunity to conduct diabetes-related research and to gain an improved understanding of career opportunities in biomedical research. Each student presented a brief summary of his/her work at a scientific symposium held at Vanderbilt University in August. Overall satisfaction with the program was high.

The NIDDK plans to continue this program in the summer of 2010.

If you are interested in becoming a preceptor for a medical student for June-August 2010, please email Linda Potter at ldpotter@umich.edu to inform her of your interest and the type of research the medical student would participate in under your mentorship.

Martha M. Funnell Begins Term as National Diabetes Education Program (NDEP) Chair

Established in 1997, the NDEP is a federally-funded program sponsored by the U.S. Department of Health and Human Services, National Institutes of Health, and the Centers for Disease Control and Prevention. It includes over 200 partners at the federal, state and local levels, working together to improve the treatment and outcomes for people with diabetes, promote early diagnosis, and prevent or delay the onset of type 2 diabetes.

Martha M. Funnell, MS, RN, CDE began a two-year term as the NDEP’s new chair on May 28, succeeding Francine Kaufman, M.D. As chair of the NDEP, Ms. Funnell is charged with expanding the program’s partnerships, strengthening collaborations with key organizations, and disseminating information to encourage people to take action to prevent or control diabetes. Ms. Funnell has participated on NDEP committees since 2004 and has served as vice chair of the NDEP’s Health Care Professional Work Group. She is currently guiding the NDEP through its Support Behavior Change Initiative, which is focused on helping consumers and health care professionals by identifying information that can help people to make and sustain lifestyle changes.

Ms. Funnell’s professional efforts have been committed to the development, evaluation, and dissemination of educational programs in patient empowerment and collaborative approaches to diabetes care and education, culturally specific interventions, and the development of patient education curricula.

Pilot and Feasibility Grants (P/FS)

The MDRTC Grants Advisory Council will meet in November 2009 to review applications for P/FS grants from researchers across the University of Michigan. This program provides a minimum of $200,000 per year for P/FS grant awards and through a cost-sharing agreement with the Michigan Comprehensive Diabetes Center, provides an additional $100,000 per year for a Diabetes Interdisciplinary Studies Program grant. The goal of the grant program is to enable awardees to generate a sufficient body of preliminary information for a successful application for major research funding from the National Institutes of Health or other national granting agencies. During the history of the MDRTC, more than one-half of P/FS grants awarded have developed into fruitful extramurally-funded research programs.

MDRTC Represented at American Diabetes Association (ADA) and Endocrine Society Meetings:
69th Scientific Session of the American Diabetes Association

The MDRTC was well represented at the 69th Scientific Session of the American Diabetes Association held June 2009 as evidenced by the number of symposia, oral presentations, and posters MDRTC members presented at the scientific session.

ADA Symposia:
Electronic Records With Patient Portals—Is the Future Now? J. D. Piette

Liver vs. Peripheral Tissues (Muscle and Fat). C. F. Burant

Postpartum Glucose Screening—Are There Programs to Improve Postpartum Screening Performance? C. Kim

National Diabetes Education Program in Action—Identifying and Sharing Information to Support Behavior Change for People with Diabetes and People at Risk. M. M. Funnell

Cost and Effectiveness of Diabetes Prevention and Better Diabetes Care. W.H. Herman, MD

ADA Oral Presentations:
Baseline Characteristics and Mortality in ACCORD. J. Calles, M., D. E. Bonds, R. A., Failor, F. I. Beigi, V. Fonseca, R. Cohen, D. Simons-Morton, D. Kendall, L. Lovato, R. Pop-Busui

The Cost-Utility of Bariatric Surgery in Managed Care. L. Mcewen, R. B. Coelho, L. M. Baumann, D. Bilik, W. H. Herman, MD

Cardiovascular Denervation and Oxidative Stress in Subjects with Metabolic Syndrome. R. Pop-Busui, D. Raffel, J. Byun, A. Giri, K. Ryan, M. Rubenfire, M. Brown, S. Pennathur

Cardiac Autonomic Dysfunction Predicts Cardiovascular Mortality in the Action To Control Cardiovascular Risk in Diabetes (ACCORD) Trial. R. Pop-Busui, G. Evans, H. C. Gerstein, V. Fonseca, S. Genuth, J. Fleg, M. Corson, R. Grimm, R. Prineas

The Extracellular Epitope of IA-2 (aa Residues 1-256) Is Associated with a Heightened Risk of Type 1 Diabetes. M. P. Morran, A. Casu, S. Pietropaolo, Y. Zhang, V. C. Arena, D. J. Becker, M. Pietropaolo

Lack of Insulin Receptor Substrate 2 (Irs2) in Leptin Receptor (LepRb)-Expressing Neurons Causes Obesity and Diabetes. M. Sadagurski, R. L. Leshan, M. G. Myers Jr., M. F. White

ADA Posters:

TBC1D1 Phosphorylation and Insulin-independent Glucose Transport Are Increased Immediately Post-Exercise in Rat Skeletal Muscle, but TBC1D1 Phosphorylation Is Reversed at 3h Post-Exercise When Insulin Sensitivity Is Increased. K.Funai, G. G. Schweitzer, N.Sharma, M. Kanzaki, G. D. Cartee.

Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits. J C. Florez, C. Langenberg, I. Prokopenko, Richasaxena, N. Soranzo, A. U. Jackson, E. Wheeler, N. L. Glazer, N. Bouatia-Naji, R. Sladek, P. Froguel, R. M. Watanabe, J. B. Meigs, L. Groop, M. I. Mccarthy, M. Boehnke, J. Dupuis, I. Barroso

Mutant Proinsulin-Induced Neonatal Diabetes. M. Liu, J. Wright, P. Arvan

Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes. I. Hodish, M.Liu, G. Rajpal, D. Larkin, R. Holz, A. Adams, L. Liu, P. Arvan

Mendelian Randomization Studies of the Role of Biomarkers in Type 2 Diabetes. J. Perry, E. Zeggini, L. Scott, R. Saxena, B. Voight, The Diagram Consortium, L. Ferrucci, M. Maggio, G. Paolisso, T. Sparso, C. Langenberg, H. Grallert, C. Palmer, A. Morris, V. Steinthorsdottir, A. Jackson, U. Thorsteinsdottir, K. Stefansson, M.l Boehnke, T. Hansen, O. Pedersen, T. Illig, N. Wareham, I. Barroso, A. Hattersley, M. Mccarthy, T. Frayling

The Michigan Model for Diabetes. W. Ye, J. Barhak, M. B. Brown, W.H. Herman

Pdx-Cre ErbB4flox/flox Mice Become Obese with Age and Display Decreased Ambulatory Activity and Defective Thermoregulation. W. Yan, H. Muenzberg, P. J. Dempsey

Lack of Sensitivity of HbA1c Determinations in Diagnosis or Screening for Early Diabetic States. S.S. Fajans, W.H. Herman

Safety and Efficacy of Insulin Glargine Compared with NPH Insulin in Older Adults with Type 2 Diabetes: Results from a Pooled Analysis. P.l G. Lee, A. M. Chang, C. S. Blaum, A. A. Vlajnic, M. F. Miller, J. B. Halter

Sustained Glucose and Intact Islet Architecture Are Necessary for Imprinting of Calcium and Insulin Rhythms in Mouse Islets. C. S. Nunemaker, J.F. Dishinger, S. B. Dula, R. Wu, K. R. Reid, R. T. Kennedy, L. S. Satin

Family History among Parous Women with Histories of Gestational Diabetes Mellitus Only and Diagnosed Diabetes Mellitus in the Third National Health and Nutrition Examination Survey. C. Kim, T. Liu, R. Valdez, G. L. Beckles

Impact of Iron Deficiency upon HbA1c Levels among Men and Women without Diabetes NHANES 1999-2006. C. Kim, K. M. Bullard, W. H. Herman, G. L. Beckles

Sexual Dysfunction in Women with Type 1 and Type 2 Diabetes Mellitus. L. P. Wallner, A. V. Sarma, C. Kim

Family Planning Practices among Women with Diabetes and Overweight and Obese Women in the 2002 National Survey for Family Growth. A. Vahratian, J. S. Barber, J. M. Lawrence, C. Kim

Steroid Receptor RNA Activator, SRA, Promotes Adipocyte Differentiation and Insulin-Sensitivity. B. Xu, I. Gerin, O. A. Macdougald, R. J. Koenig

Role of Jak2 Signaling in Leptin Action Independent of Leptin Receptor Tyrosine Phosphorylation. S. A. Robertson, R. Ishida-Takahashi, M. G. Myers Jr.

Leptin Receptor Neurons in the Lateral Hypothalamus Regulate the Mesolimbic Dopamine System and Energy Balance. G. M. Leinninger, Y.-H Jo, R. L. Leshan, G. W. Louis, H.Yang, J. G. Barrera, H. Wilson, J. C. Jones, C. J. Rhodes, S. Chua Jr., S. Diano, T. L. Horvath, R. J. Seeley, J. B. Becker, H. Munzberg, Martin G. Myers Jr.

Parents' Perceptions of Mealtimes Differ Based on the Timing of Mealtime Insulin Dosing in Young Children with Type 1 Diabetes. S. R. Patton, L.B. Williams, L. M. Dolan, S. J. Eder, S. W. Powers

Identification of Mup1 as a Regulator of Glucose and Lipid Metabolism in Mice. Y. Zhou, L. Jiang, L. Rui

Lack of Insulin in Type-1 Diabetes Inhibits Pancreatic Digestive Enzymes Synthesis and Secretion. M. Dolors Sans, S. J. Crozier, L. G. D'alecy, N. L. Vogel

Mendelian Randomization Studies of the Role of Biomarkers in Type 2 Diabetes. J. Perry, E. Zeggini, L. Scott, R. Saxena, B. Voight, The Diagram Consortium, L. Ferrucci, M. Maggio, G.. Paolisso, T. Sparso, C. Langenberg, H. Grallert, C. Palmer, A. Morris, V. Steinthorsdottir, A. Jackson, U.Thorsteinsdottir, K. Stefansson, M. Boehnke, T. Hansen, O. Pedersen, T. Illig, N. Wareham, I. Barroso, A. Hattersley, M. Mccarthy, T. Frayling

Feasibility of Diabetes Prevention in Arab Americans: Preliminary Findings. L. A. Jaber, M.B. Brown, N.R. Pinelli, W. H. Herman

Estimating the Potential Cardiovascular Benefit of A1c Reduction and Weight Loss in Patients with Type 2 Diabetes Treated with Exenatide for at Least Three Years. J. H. Best, W. H. Herman, M. Wintle

2009 (91st) Annual Meeting and Endocrine Society

Symposia:

Hyperlipidemia: A new therapeutic target for diabetic neuropathy. E. L. Feldman

Nutrient-induced changes in peripheral blood metabolomics and transcriptions. C. F. Burant

Molecular and neural mechanism of leptin action. M. G. Myers, Jr.

Oral Presentations:

Impact of fitness, insulin and gynecologic age on luteinizing hormone secretory dynamics in adolescent females. J. Z. Kasa-Vubu, J. Vain, K. B. Welch

Leptin improved nonalcoholic steatohepatitis (NASH) scores in patients with NASH and relative leptin deficiency. E. A. Oral, V. Uhley, T. Chenevert, H. Hussain, H. Conjeevaram, C. Burant

Mutant proinsulin-induced neonatal diabetes. M. Liu, J. Wright, P. Arvan

Novel action of growth hormone (GH) on macrophage results in GH-dependent decrease in IL-1B secretion and increased adipogenesis. C. Lu, R. K. Menon

Novel functions of KRAB zinc finger proteins in intermediary metabolism. C. J. Krebs, D. M. Robins

The role of jagged1-dependent notch signaling in adrenocortical carcinogenesis. D. P. Simon, T. J. Giordano, G. D. Hammer

Ventromedial hypothalamic PTEN regulates peripheral insulin sensitivity through adipogenesis. L. Wang, D. M. Opland, S. A. Schroer, D. Choi, K.-T. T. Nguyen, Y. Liu, G. Sweeney, A. Suzuki, T. W. Mak, M. G. Myers, M. Woo

Posters:

Agouti-related peptide (AgRP) neurons as key targets for the influence of prenatal testosterone on the metabolic system of the ewe. K. M. Sheppard, G. Cheng, L. M. Coolen, V. Padmanabhan, N. Lehman

Altered growth patterns of the Mountain Ok people of Papua New Guinea over 25 years of change. A. Adhikari, A. Sen, R. C. Brumbaugh, J. Schwartz

An inflection of circulating DHEAS is related to ovarian status during the menopausal transition. S. L. Crawford, N. Santoro, G. A. Laughlin, M. F. Sowers, D. McConnell, K. Sutton-Tyrrell, G. Weiss, M. Vuga, B. L. Lasley

Anti-Mullerian hormone and inhibin B variability during normal menstrual cycles. M. F. Sowers, D. McConnell, K. Gast, J. McCarthy, J. F. Randolph.

βIIΣ1-spectrin is a novel SH2B1β-interacting partner. N. J. Lanning, C. Carter-Su

Clinical mutations reveal important roles of SUMOylation in androgen receptor based diseases. S. Mukherjee, E. Bolton, J. A. Iniguez-Lluhi

Collagenolysis initiates diet-induced obesity by coupling collagen catabolism and lipid biosynthesis. T.-H. Chun, M. Inoue

Developmental programming: Differential effects of prenatal testosterone excess on insulin target tissues. S. E. Nada, R. Thompson, V. Padmanabhan

Developmental programming: Opposing effects of prenatal testosterone and estradiol excess on insulin sensitivity and reproductive cyclicity in sheep and modulation by postnatal estradiol. A. Veiga-Lopez, V. Padmanabhan

Dyslipidemia-induced neuropathy in mice: The role of OxLDL/LOX-1. A. M. Vincent, J. M. Hayes, L. L. McLean, A. Vivekanandan-Giri, S. Pennathur, E. L. Feldman

Evidence that luteinizing hormone receptor mRNA and vascular endothelial growth factor mRNA expression are closely coupled during follicle maturation, ovulation and ligand induced down-regulation of the receptor in the ovary. M. Harada, H. Peegel, K. M. J. Menon

Expression of the GH-regulated gene KLF5 is mediated by multiple promoter motifs in adipocytes. T. X. Cui, M. Rathore, Z. Qin, J. Schwartz

Human chorionic gonadotropin stimulates growth and proliferation of Theca-interstitial cells by activating the mTOR-dependent pathway. M. Palaniappan, P. P. Kayampilly, K. M. J. Menon

Hyperglycemia-induced Tau cleavage in vitro and in vivo: A possible link between diabetes and Alzheimer’s disease. B. Kim, S. Oh, C. Backus, E. L. Feldman

Hypoxia alters IGF actions in skeletal muscle cells by reprogramming glucose metabolism and multiple signaling pathways. H. Ren, C. Duan

Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. X. Wang, L. Lu, Y. Li, Q. Feng, M. Li, C. Chen, C. Zhang, C. Duan

Regulation of Akt/mTOR signaling in podocytes by growth hormone (GH): Implications for the pathogenesis of diabetic nephropathy. A. K. Paupulati, J. Sun, K. Inoki, R. K. Menon

Regulation of luteinizing hormone receptor (LHR) expression by Mevalonate Kinase (MVK): Evidence for translational suppression of LHR mRNA by translocation of MVK to ribosomes during ligand-induced downregulation. B. Menon, H. Peegel, K. M. J. Menon

Regulation of Sf-1 transcription factor by Pod1/Capsulin/TCF21 in steroidogenic cell lines. C. F. P. Lotfi, J. H. Heaton, S. E. Quaggin, G. D. Hammer

Role of microRNAs in adrenal development and carcinogenesis. K. T. Krill, G. D. Hammer

Sex differences and the effect of prenatal testosterone on dopamine cells of the ventral tegmental area in the sheep. E. C. Brown, T. M. Lee, V. Padmanabhan, M. N. Lehman, L. M. Coolen
Three year review of a hospital intensive insulin program. R. Y. Gianchandani, M. Fishe

In the News

Sean Morrison, PhD, director of the Center for Stem Cell Biology, was quoted in articles in TIME, the Detroit News, CBS News, the New York Post, the Chicago Tribune, the Boston Globe, and the San Francisco Chronicle about stem cell research. The articles described what types of stem cell research can be covered by taxpayer dollars since the Obama administration lifted some restrictions. "This will eventually make hundreds of new stem cell lines available for use,” Morrison said.

Poor blood sugar control in type 2 diabetes can worsen depression
Researchers at the University of Michigan have determined that poor glycemic control in diabetics/patients may be a risk factor of worsened depressive symptoms. Lead author James Aikens, PhD, a clinical psychologist, Associate Professor in Family Medicine and Assistant Professor in Psychiatry at the University of Michigan Medical School says “Our findings suggest an opportunity for physicians to more carefully monitor these patients for intensified depressive symptoms, or perhaps to initiate treatment for depression”.
The study appearing in the July issue of Diabetes Care. Diabetes Care, volume 32, number 7, pages 1177-1181, July 2009.
Additional authors: D. W. Perkins, MD, B. Lipton, MPH, and JD. Piette, PhD, associate director and chief of the prevention and control division of the Michigan Diabetes Research and Training Center and professor of internal medicine at U-M Medical School.

Heart surgery no better than drugs for patients with type 2 diabetes
There is no difference in mortality among patients with type 2 diabetes and stable heart disease who received prompt bypass surgery or angioplasty compared to drug therapy alone, according to a landmark study focused exclusively on patients with both conditions.
Eric Bates, M.D., an interventional cardiologist and Professor of Internal Medicine at the U-M Medical School, and Rodica Pop-Busui, MD, PhD, an Assistant Professor in the Metabolism, Endocrinology and Diabetes Division of the Department of Internal Medicine at the U-M Medical School, directed the U of M clinical site.

This study was published in the New England Journal of Medicine and presented at the American Diabetes Association 69th Scientific Sessions, N Engl J Med. 2009 Jun 11;360(24):2503-15. Epub 2009 Jun 7.

Triglycerides implicated in diabetes nerve loss
A blood test for triglycerides may allow doctors to predict which patients with diabetes are more likely to develop the serious, common complication of neuropathy.
University of Michigan and Wayne State University researchers analyzed data from 427 diabetic patients with neuropathy. The data revealed that if a patient had elevated triglycerides, he or she was significantly more likely to experience worsening neuropathy over a period of one year. Other factors did not turn out to be significant.

“These results set the stage for clinicians to be able to address lowering lipid counts with their diabetes patients with neuropathy as vigilantly as they pursue glucose control,” says Eva L. Feldman, MD, PhD, senior author of the study and the Russell N. DeJong Professor of Neurology at the U-M Medical School. Diabetes, http://diabetes.diabetesjournals.org/cgi/reprint/db08-1771v1

Accolades to MDRTC Members

Massimo T. Pietropaolo, MD, Professor of Internal Medicine; Professor of
Pediatrics and Communicable Diseases received an award in December from his alma mater, the University of Perugia Medical School in Perugia, Italy, for his career achievements in medicine. Dr. Pietropaolo is one of only four graduates from Perugia’s medical school selected for the award, which was conferred in honor of the university’s celebration of its seventh centenary.

American Association for the Advancement of Science (AAAS) Fellows
The AAAS is the world's largest general scientific society and publisher of the journal Science.
Election as an AAAS Fellow, a tradition that began in 1874, is an honor bestowed upon AAAS members by their peers. This honor was bestowed on two MDRTC members.

Alan R. Saltiel, PhD, John Jacob Abel Collegiate Professor in the Life Sciences, Mary Sue Coleman Director of the Life Sciences Institute, Professor of Internal Medicine, Professor of Molecular and Integrative Physiology. He was honored by AAAS for distinguished research contributions toward understanding the specificity of signal transduction and insulin action, and for leadership as director of the Life Sciences Institute.

Stephen J. Weiss, MD, chief of the Division of Molecular Medicine & Genetics, Upjohn Professor of Medicine and Oncology, and Research Professor at the Life Sciences Institute. Weiss studies the mechanisms that white blood cells, endothelial cells and cancer cells use to remodel tissue structure during events ranging from inflammatory disease and angiogenesis to cancer. AAAS recognized him for distinguished research contributions toward the understanding of protease function and remodeling of the extracellular matrix, and for academic leadership as Editor-in-Chief of the Journal of Clinical Investigation.

Liangyou Rui, PhD, has been named on of three Star Reviewers for the Endocrinology and Metabolism Section of the American Journal of Physiology.

Funding Opportunities

The following funding opportunities in the area of diabetes, its complications and endocrine disorders can be found at the Diabetes Centers website at http://www.diabetescenters.org/

Upcoming Research Conferences

For more information on these conferences, please go to the News and Events section of the MDRTC website at http://www.med.umich.edu/mdrtc/news_events/index.html

National Diabetes Centers Website

The newly developed National Diabetes Center website located at http://www.diabetescenters.org/ contains a wealth of information about the NIDDK-supported Diabetes Endocrinology Research Centers (DERCs) and Diabetes Research and Training Centers (DRTCs). The website provides detailed information on each DERC and DRTC and identifies key personnel, cores, and services. The site also contains recent publications from each center, new programs supported by NIDDK, and new funding opportunites. We suggest that you book mark this site for future reference.