Description of Research: Laraine
Our research focuses upon the epidemiology of healthcare
associated infections including antibiotic resistant
Dialysis related infections
The major focus of our research has been bloodstream
infections in patients receiving dialysis for acute
renal failure. Our analysis has shown that the rate
of bloodstream infections for patients in ICUs receiving
the continuous renal replacement therapy mode of dialysis
have a high rate of catheter associated bloodstream
infections compared to other ICU patients. We are
analyzing potential risk factors which might be modifiable
to decrease rates of infection.
Emerging antibiotic resistance
We are interested in the emergence of antibiotic resistant
organisms in the hospital and the community. We are
currently evaluating the risk factors associated with
development of extended spectrum beta lactamase producing
gram negative infections in hospitalized patients.
We are also interested in the emergence of carbapenamase
producing gram negative bacteria in hospitalized patients.
Washer, LL and Chenoweth, CE. Infection control strategies
for methicillin-resistant Staphylococcus aureus and
vancomycin-resistant enterococcus: What is the evidence?
Journal of Clinical Outcomes Management 13(6): 333-341,
Washer, L and Malani, P. Travel vaccines in older
adults. Clinical Geriatrics 14(8): 36-44, 2006.
Washer LL, Riddell IV J, Rider J, Chenoweth CE.
Mycobacterium neoaurum bloodstream infections: report
of 4 cases and review of the literature. Clin Infect
Dis 2007; 45:e10-13.
Cinti SK, Washer LL, Chenoweth CE. Clostridium difficile
colitis: A reemerging threat. J Clin Outcomes Management
14 (9): 505-514, 2007.
Chenoweth CE, Washer LL, Obeyesekera K, Friedman
C, Brewer K, Fugitt GE, Lark R. Ventilator-associated
pneumonia in the home care setting. Infect Contr Hosp
Epidemiol 28 (8): 910-915, 2007.
Cinti SK, Washer LL, Chenoweth CE. Clostridium difficile-associated
disease. Infectious Diseases Board Review Manual.
Hosp Phys 10 (3):1-12, 2007.
Young MH, Washer L, Malani PN. Surgical site infections
in older adults - Epidemiology and management. Drugs
Aging 25 (5): 399-414, 2008.
Rasheed JK, Biddle JW, Anderson KF, Washer L, Chenoweth
C, Perrin J, Newton DW, Patel JB. Detection of KPC-1
Carbapenem-hydrolyzing enzyme in clinical isolates
of Citrobacer freundii and Klebsiella oxytoca carrying
a common plasmid. J Clin Microbiol 46 (6):2066-2069,
Shuman EK, Washer LL, Arndt JL, Zalewski CA, Hyzy RC, Napolitano LM, Chenoweth CE. Analysis of Central Line-Associated Bloodstream Infections in the Intensive Care Unit after Implementation of Central Line Bundles. Infect Contr Hosp Epidemiol 31 (5): 551-553, 2010.
Gandhi TN, DePestel DD, Collins CD, Nagel J, Washer LL. Managing antimicrobial resistance in intensive care units. Crit Care Med 38 (8): S315-S323 Suppl. S, 2010.