Description of Research: Krishna Rao
Dr. Rao’s clinical and research interests include the diagnosis and management of healthcare-associated infections, especially Clostridium difficile infection. His clinical work includes managing the University of Michigan Fecal Microbiota Transplantation (stool transplant) program for recurrent Clostridium difficile infection, which he co-founded. He also works with the Antimicrobial Subcommittee of the Pharmacy and Therapeutics Committee, where he provides expertise and support in the use of procalcitonin, a novel and promising biomarker for bacterial infections. He is also studies infections in older adults and the biology of aging, in affiliation with the Claude D. Pepper Older Americans Independence Center of the University of Michigan Institute of Gerontology.
His research is primarily conducted through the Enterics Research Investigative Network. His overall research aim is to investigate how biochemical, microbiological, and clinical factors can help decision-making in the treatment of healthcare-associated infections, and he hopes to ultimately integrate these factors into robust risk-prediction algorithms for use by clinicians.
Rao K, Walk ST, Micic D, Chenoweth E, Deng L, Galecki AT, Jain R, Trivedi I, Yu M, Santhosh K, Ring C, Young VB, Huffnagle GB, Aronoff DM. Procalcitonin Levels Associate with Severity of Clostridium difficile Infection. PLoS One. 2013;8(3):e58265. PMID: 23505476.
Rao K, Micic D, Chenoweth E, Deng L, Galecki AT, Ring C, Young VB, Aronoff DM, Malani PN. Decreased Functional Status as a Risk Factor for Severe Clostridium difficile Infection among Hospitalized Older Adults. J Am Geriatr Soc. 2013;in press.
Rao K, Berland D, Young C, Walk ST, Newton DW. The Nose Knows Not: Poor Predictive Value of Stool Sample Odor for Detection of Clostridium difficile. Clin Infect Dis. 2013;56(4):615-6. PMID: 23166192.
Bagdasarian N, Rao K, Malani PN. Changing Epidemiology and Control of Clostridium difficile in Older Adults. Curr Transl Geriatr and Exp Gerontol Rep. 2013;in press.