Description of Research: Tejal Gandhi
Dr. Gandhi is a member of the HIV/AIDS Treatment
Program and completed additional training specifically
in this area. Research interests include the impact
of incompletely suppressive antiretroviral (ARV) regimens
on opportunistic infection (OI) rates, immunologic
outcomes, virologic outcomes, and occurrence of drug
resistant mutations in patients with highly drug resistant
HIV. We have found that maintaining an incompletely
suppressive ARV regimen reduces OI rates and maintains
a durable virologic and immunologic response in many
patients. In addition, we have also found that patients
with highly drug resistant HIV continue to acquire
new drug resistant mutations while on a failing ARV
Dr. Gandhi is a member of the Antimicrobial Stewardship
Program for the hospital. The goal of our program
is to ensure effective and appropriate utilization
of antimicrobials for hospitalized patients, while
minimizing unintended consequences of antimicrobial
use (c.diff infection, selection of drug resistant
pathogens, and drug toxicities). In addition, we participate
in the development of evidence based guidelines for
antimicrobial use. Research interests include the
diagnosis and management of urinary tract infections
in hospitalized patients.
Psarros G, Riddell J, Gandhi T, Kauffman CA, Cinti SK. Bartonella henselae Infections in Solid Organ Transplant Recipients: Report of Five Cases and Review of the Literature. Medicine (Baltimore) 2012;91(2): 111-21.
Signs KA, Stobierski MG, Gandhi TN. Q Fever Cluster Among Raw Milk Drinkers in Michigan, 2011. Clin Infect Dis 2012; 55(10) 1387-9.
Antworth A, Collins C, Kunapuli A, Klein K, Carver P, Gandhi T, Washer L, Nagel J. Impact of an Antimicrobial Stewardship Program Comprehensive Care Bundle on the Management of Candidemia. Pharmacotherapy 2013; 33(2):137-43.
Khateeb R, Gandhi T, Dhaliwal G. A Raw Deal. Journal of Hospital Medicine 2013; 8(8):464—67. (Case presentation and Review)
Huang A, Newton D, Kunapuli A, Gandhi TN, Washer LL, Isip J, Collins CD, Nagel JL. Rapid Organism Identification via Matrix-Assisted Laser Desorption Ionization Time-of-Fligh Combined with Antimicrobial Stewardship Team Intervention Decreases Mortality and Improves Time to Clinical Response in Adult Patients with Bacteremia and Candidemia. Clin Infect Dis 2013;57(9):1237-45.
Hartley S, Valley S, Kuhn L, Washer L, Gandhi T, Meddings J, Chenoweth C, Malani A, Saint S, Srinivasan A, Flanders SA. Inappropriate Testing for Urinary Tract Infection in Hospitalized Patients: An Opportunity for Improvement. Infect Control Hosp Epidemiol 2013;34 (11):1204-7.
Jameson A, Kauffman CA, Cinti, SK, Gandhi T. Cytomegalovirus Appendicitis in Human Immunodeficiency Virus Infection. Infect Dis Clin Pract 2014; 22(4):190-193.
Nagel J, Huang A, Kunapuli A, Gandhi T, Washer L, Lassiter J, Patel T, and Newton D. Impact of Antimicrobial Stewardship Intervention in Conjunction with Rapid Diagnostic Testing on Management of Patients with Positive Cultures with Coagulase-Negative Staphylococci. J Clin Microbiol 2014;52(8):2849-54
Hartley S, Valley S, Kuhn L, Washer L, Gandhi T, Meddings J, Chenoweth C, Malani AN,
Saint S, Srinivasan A, Flanders S. Overtreatment of Asymptomatic Bacteriuria: Identifying
Targets for Improvement. Infect Contol Hosp Epidemiol 2015 (Accepted)
Nagel J, Washer L, Kunapuli A, Heidmann J, Pisani J, Gandhi T. Clinical Efficacy of
Fosfomycin for the Treatment of Uncomplicated and Complicated Lower Urinary Tract
Infections. Submitted to Antimicrobial Agents and Chemotherapy Oct 2014