Be sure to visit the University of Michigan’s
main gateway to clinical research trials:
There you can find trials actively recruiting
at U of M and general information about research and
how to participate.
For specific information on HIV research
you can also speak with your medical provider at your
next appointment or research personnel at 734-647-9830
Current Research Seeking HIV+ Individuals
Molecular Mechanisms of HIV Disease Pathogenesis
Sponsor: National Institutes of
Goal: On therapy viral load decreases,
but once stopped viral load becomes high again. Where
is the virus waiting in the body when is it “undetectable”
in the blood? This study suggests it may be bone marrow.
Method: A sample of bone marrow
is taken from the hip. Requires a 1 hour visit in
the hospital for the procedure.
Recruiting: 10 people with viral
load over 50,000 c/mL and no serious illness.
IMPACT: I50L mutation on a failed Reyataz (atazanavir)
Sponsor: Bristol-Myers Squibb
Goal: Therapy can become ineffective
due to the development of resistance when the virus
mutates to get around the drug. Tests like a genotype
can detect these mutations and provide your doctor
information for a better regimen for you. This study
suggests one specific mutation called the I50L
substitution occurs with Reyataz, and seeks to
better understand treatment options.
Method: A blood sample is taken
to test. Requires 1 blood draw in Taubman Center.
Recruiting: People taking Reyataz
with a viral load over 1,000 c/mL.
Goal: Long term data collection
on the FDA approved Maraviroc. To track the rates
of •CDC Category C Opportunistic Infections
•Viral encephalitis •All malignancies
•Liver failure •Myocardial infarction
or ischemia •Rhabdomyolysis •Death from
Method: There are no special appointments.
Patients come to their normal clinical appointments
in Taubman Center and the data is collected from the
Recruiting: Any patient in need
of salvage therapy considering Maraviroc.