Research Faculty


Yi Zhang, M.D., Ph.D.
Assistant Professor of Internal Medicine
Phone: 734-647-7755

Lab website:

Campus address:
University of Michigan Comprehensive Cancer Center
1500 East Medical Center Drive
6219 Cancer Center/SPC 5942
Ann Arbor, MI 48109


Research Interests


Education and Training

1983 B.S., Zheng-jiang Medical college, Zheng-jiang, P.R. China
1989 M.Sc., Immunology & Microbiology, Suzhou Medical College, Suzhou, P.R. China
1998 M.D., Ph.D., Molecular Medicine & Immunology, University of Tokyo, School of Medicine, Tokyo, Japan
1998-2000 Postdoctoral Research Fellow, School of Medicine, University of Pennsylvania, Philadelphia, PA
2000-2003 Research Associate, Immunology, Department of Medicine, University of Pennsylvania, Philadelphia, PA

Honors & Awards

1995 Prize for academic achievement, National Education Misistry fo China
1996 Special Prize for the Most Excellent Young Teacher, Education Committee of Jiangsu Province, China
1998 Special Prize for Scientists with Extraordinary Academic Achievements, State Council of P.R. China
2009 Damon Runyon Rachleff Innovation Award
2010 Research Scholars Grant, American Cancer Society
2011 New Investigator Award, Department of Defense, USA
2012 Bai Yu Lan Prize for Research Scholar, Shanghai, China

Selected Publications (2008-present)

Croyle MA, Patel A, Tran KN, Gray M, Zhang Y, Strong JE, Feldmann H, Kobinger GP. Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice. PLoS One, 2008; 3(10):e3548. (PMID 18958172)  PMC 2569416.

He S, Cao Q, Qiu Y, Mi J, Zhang JZ, Jin M, Ge H, Emerson SG, Zhang Y.  A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3 neutralizing antibody. J Immunol, 2008 Dec 1; 181(11):7581-7592. (PMID 19017947).

He S, Cao Q, Yoneyama H, Ge H, Zhang Y.  MIP-3alpha and MIP-1alpha rapidly mobilize dendritic cell precursors into the peripheral blood. J Leukoc Biol, 2008 Dec; 84(6):1549-1556. (PMID 18791167).

Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS.  Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest, 2009 Dec; 119(12):3519-3529. (PMID 19959876)  PMC 2786808.

Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y. Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Biol Blood Marrow Transplant, 2010 Jun; 16(6):751-771. (PMID 20116439)  PMC 2913321.

He S, Kato K, Jiang J, Wahl DR, Mineishi S, Fisher EM, Murasko DM, Glick GD, Zhang Y. Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells. PLoS One, 2011; 6(5):e20107. (PMID 21611151)  PMC 3096660.

Mochizuki K, He S, Zhang Y.  Notch and inflammatory T-cell response: new developments and challenges. Immunotherapy, 2011 Nov; 3(11):1353-1366. (PMID 22053886).

Zhang Y
, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I.  Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Blood, 2011 Jan 6; 117(1):299-308. (PMID 20870902)  PMC 3037751.

He S, Wang J, Kato K, Xie F, Varambally S, Mineishi S, Kuick R, Mochizuki K, Liu Y, Nieves E, Mani RS, Chinnaiyan AM, Marquez VE, Zhang Y.  Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells. Blood, 2012 Feb 2; 119(5):1274-1282. (PMID 22117046)  PMC 3338164.

Wong G, Richardson JS, Pillet S, Patel A, Qiu X, Alimonti J, Hogan J, Zhang Y, Takada A, Feldmann H, Kobinger GP.  Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates. Sci Transl Med, 2012 Oct 31; 4(158):158ra146. (PMID 23115355).

Singh L, Brennan TA, Kim JH, Egan KP, McMillan EA, Chen Q, Hankenson KD, Zhang Y, Emerson SG, Johnson FB, Pignolo RJ.  Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging. Stem Cells, 2013 Mar; 31(3):607-611. (PMID 23193076)  PMC 3582822.

Mochizuki K, Xie F, He S, Tong Q, Liu Y, Guo YJ, Kato K, Yagita H, Mineishi S, and Zhang Y. Delta-like Ligand 4 Identifies a Previously Uncharacterized Population of Inflammatory Dendritic Cells That Plays Important Roles in Eliciting Allogeneic T-cell Responses in Mice. Journal of Immunology 2013. 190(7):3772-82. doi: 10.4049/jimmunol.1202820.

He S, Tong Q, Bishop DK, and Zhang Y.  Histone methyltransferase and histone methylation in inflammatory T cell responses. Immunotherapy, 2013 (in press)

Rev. 7/13