Research Faculty


Haiying Sun, Ph.D.
Adjunct Research Assistant Professor
Phone: 734-615-5473

Campus address:
University of Michigan Comprehensive Cancer Center
Room 3110/SPC 5934
1500 E. Medical Center Drive
Ann Arbor, MI 48109

Research Interests

Design and synthesis of small molecular ligands to target proteins which play important roles in human diseases

Education and Training

1991 B.S., Chemistry, Lanzhou University, Department of Chemistry, Lanzhou, China
1997 M.S., Organic Chemistry, Lanzhou University
2000 Ph.D., Organic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, Chine
2000-2002 Postdoc Research Fellow, Georgetown University
2002-2003 Postdoc Research Fellow, University of Michigan

Selected Publications (2008-present)

  1. Sun H, Nikolovska-Coleska Z, Yang CY, Qian D, Lu J, Qiu S, Bai L, Peng Y, Cai Q, Wang S. Design of small-molecule peptidic and nonpeptidic Smac mimetics. Acc Chem Res, 2008 Oct; 41(10):1264-1277. (PMID 18937395)  PMC 2676167.

  2. Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S.  SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res, 2008 Nov 15; 68(22):9384-9393. (PMID 19010913) PMC 2784911.

  3. Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP). J Med Chem, 2008 Nov 27; 51(22):7169-7180. (PMID 18954041) PMC 2688463.

  4. Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. J Med Chem, 2008 Dec 11; 51(23):7352-7355. (PMID 19012392)  PMC 2662380.

  5. Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D, Wang S. Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases. J Med Chem, 2008 Dec 25; 51(24):8158-8162. (PMID 19049347)  PMC 2679375.

  6. Sun W, Nikolovska-Coleska Z, Qin D, Sun H, Yang CY, Bai L, Qiu S, Wang Y, Ma D, Wang S. Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. J Med Chem, 2009 Feb 12; 52(3):593-596. (PMID 19138149) PMC 2795317.

  7. Yang CY, Sun H, Chen J, Nikolovska-Coleska Z, Wang S.  Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction. J Am Chem Soc, 2009 Sep 30; 131(38):13709-13721. (PMID 19736924)  PMC 2773700.

  8. Sun H, Liu L, Lu J, Qiu S, Yang CY, Yi H, Wang S.  Cyclopeptide Smac mimetics as antagonists of IAP proteins. Bioorg Med Chem Lett, 2010 May 15; 20(10):3043-3046. (PMID 20443226) PMC 2997469.

  9. Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S.  Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem, 2010 Sep 9; 53(17):6361-6367. (PMID 20684551)  PMC 2936695.

  10. Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang C-Y, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, Leopold L, Yang D, Wang S.  A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem, 2011; 54(8):2714-2726. (PMID 21443232).

  11. Yang J, McEachern D, Li W, Davis MA, Li H, Morgan MA, Bai L, Sebolt JT, Sun H, Lawrence TS, Wang S, Sun Y.  Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases. Mol Cancer Ther, 2011 Apr; 10(4):658-669. (PMID 21282353)  PMC 3073022.

  12. Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S.  Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. Mol Cancer Ther, 2011 May; 10(5):902-914. (PMID 21372226)  PMC 3091962.

  13. Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem, 2011 May 12; 54(9):3306-3318. (PMID 21462933)  PMC 3108148.

  14. Peng Y, Sun H, Lu J, Liu L, Cai Q, Shen R, Yang CY, Yi H, Wang S.  Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. J Med Chem, 2012 Jan 12; 55(1):106-114. (PMID 22148838).

  15. Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S.  LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFalpha expression and receptor tyrosine kinase signaling. Cancer Res, 2012 Mar 1; 72(5):1229-1238. (PMID 22241084)  PMC 3294058.

  16. Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H.  Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. J Mammary Gland Biol Neoplasia, 2012 Dec; 17(3-4):217-228. (PMID 23054134)  PMC 3534930.

  17. Sheng R, Sun H, Liu L, Lu J, McEachern D, Wang G, Wen J, Min P, Du Z, Lu H, Kang S, Guo M, Yang D, Wang S.  A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. J Med Chem, 2013 May 23; 56(10):3969-3979. (PMID 23651223).


Updated Oct 2014