Research Faculty


NEED PHOTO

Liu Liu, Ph.D.
Assistant Research Scientist

liuliull@umich.edu
Phone: 734-647-7949

Lab website:

Campus address:
University of Michigan Comprehensive Cancer Center
Room 3111
1500 E. Medical Center Dr.
Ann Arbor, MI 48109/5934

Research Interests


Education and Training

1996 B.Sc., Chemistry, Nanjing University, Nanjing, China
1999 M.Sc., Physical Chemistry, Nanjing University, China
2005 Ph.D., Photochemical Science, Center for Photochemical Science, Bowling Green State University, Bowling Green, Ohio.
Dissertation: Photoactive Metallopeptide to investigate dynamic peptide-protein interaction
2008 Postdoctoral Fellow, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA
2009 Research Fellow, University of Michgian Comprehensive Cancer Center, Ann Arbor, MI

Honors & Awards

2002-2004 Harold McMaster Predoctoral Fellowship in Photochemistry, Bowling Green State University


Selected Peer-Reviewed Publications (2008-present)


  1. Liu L, Komatsu H, Murray IV, Axelsen PH.  Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product. J Mol Biol, 2008 Apr 4; 377(4):1236-1250. (PMID 18304576).

  2. Kim YS, Liu L, Axelsen PH, Hochstrasser RM.  Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40. Proc Natl Acad Sci U S A, 2008 Jun 3; 105(22):7720-7725. (PMID 18499799)  PMC 2409414.

  3. Kim YS, Liu L, Axelsen PH, Hochstrasser RM.  2D IR provides evidence for mobile water molecules in beta-amyloid fibrils. Proc Natl Acad Sci U S A, 2009 Oct 20;106(42):17751-17756. (PMID 19815514)  PMC 2764887.

  4. Sun H, Liu L, Lu J, Qiu S, Yang CY, Yi H, Wang S.  Cyclopeptide Smac mimetics as antagonists of IAP proteins. Bioorg Med Chem Lett, 2010 Apr 3. (PMID 20456952).

  5. Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S.  Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem, 2010 Sep 9; 53(17):6361-6367. (PMID 20684551)  PMC 2936695.

  6. Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, Leopold L, Yang D, Wang S.  A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem, 2011 Apr 28; 54(8):2714-2726. (PMID 21443232)  PMC 3520070.

  7. Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem, 2011 May 12; 54(9):3306-3318. (PMID 21462933)  PMC 3108148.

  8. Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem, 2012 Oct 11; 55(19):8502-8514. (PMID 23030453)  PMC 3495162.

  9. Peng Y, Sun H, Lu J, Liu L, Cai Q, Shen R, Yang CY, Yi H, Wang S.  Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. J Med Chem, 2012 Jan 12; 55(1):106-114. (PMID 22148838).

  10. Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. J Med Chem, 2012 May 24; 55(10):4664-4682. (PMID 22448988) PMC 3397176.

  11. Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity. J Med Chem, 2012 Jul 12; 55(13):6149-6161. (PMID 22747598)  PMC 3417242.

  12. Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H.  Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. J Mammary Gland Biol Neoplasia, 2012 Dec; 17(3-4):217-228. (PMID 23054134)  PMC 3534930.

  13. Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc, 2013 Jan 16; 135(2):669-682. (PMID 23210835).

  14. Zhou H, Liu L, Huang J, Bernard D, Karatas H, Navarro A, Lei M, Wang S. Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction. J Med Chem, 2013 Feb 14; 56(3):1113-1123. (PMID 23244744).

  15. Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, StuckeyJ, Wang S. A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem, 2013 Apr 11; 56(7):3048-3067. (PMID 23448298)

  16. Kurokawa M, Kim J, Geradts J, Matsuura K, Liu L, Ran X, Xia W, Ribar TJ, Henao R, Dewhirst MW, Kim WJ, Lucas JE, Wang S, Spector NL, Kornbluth S.  A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Sci Signal, 2013 May 7; 6(274):ra32. (PMID 23652204).

  17. Sheng R, Sun H, Liu L, Lu J, McEachern D, Wang G, Wen J, Min P, Du Z, Lu H, Kang S, Guo M, Yang D, Wang S.  A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. J Med Chem, 2013 May 23; 56(10):3969-3979. (PMID 23651223).

  18. Zhao Y, Liu L, Sun W, Lu J, McEachern D, Li X, Yu S, Bernard D, Ochsenbein P, Ferey V, Carry JC, Deschamps JR, Sun D, Wang S.  Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors. J Am Chem Soc, 2013 May 15; 135(19):7223-7234. (PMID 23641733).

  19. Ma J, Komatsu H, Kim YS, Liu L, Hochstrasser RM, Axelsen PH.  Intrinsic Structural Heterogeneity and Long-Term Maturation of Amyloid beta Peptide Fibrils. ACS Chem Neurosci, 2013 Jun 12. (PMID 23701594).

  20. Ma W, Kuang H, Wang L, Xu L, Chang WS, Zhang H, Sun M, Zhu Y, Zhao Y, Liu L, XuC, Link S, Kotov NA. Chiral plasmonics of self-assembled nanorod dimers. Sci Rep, 2013; 3:1934. (PMID 23752317)  PMC 3678134.

  21. Zhao Y, Yu S, Sun W, Liu L, Lu J, McEachern D, Shargary S, Bernard D, Li X, Zhao T, Zou P, Sun D, Wang S.  A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice. J Med Chem, 2013 Jun 20. (PMID 23786219).

Updated Oct 2014