Links

 

Publications

 

View my collection, "My Bibliography" from NCBI
  1. Udvadia, A.J., Rogers, K.T., Higgins, P.D.R., Murata, Y., Martin, K.H., Humphrey, P.A., Horowitz, J.M.  “Sp-1 binds promoter elements regulated by the RB protein and Sp-1 mediated transcription is stimulated by RB coexpression”.  Proceedings of the National Academy of Sciences USA 1993; 90:  3265-3269.
  2. Rogers, K.T.*, Higgins, P.D.R.*, Milla, M.M., Phillips, R.S., and Horowitz, J.H. “DP-2, a heterodimeric partner of E2F:  Identification and characterization of DP-2 proteins expressed in vivo”.  Proceedings of the National Academy of Sciences USA 1996; 93:  7594-7599.
  3. Higgins, P.D.R. and Askari, FK. Barrett's Esophagus:  Diagnosis and Therapy. The National Organization of Rare Diseases Guide to Rare Diseases, 2001, Lippincott. Review.
  4. Higgins, P.D.R., Russo, C.A., Scheurer, M., Duvall, W.L. “How Well do we Treat Elevated Lipids?” North Carolina Medical Journal 2002; 63(5):  247-52.
  5. Higgins, P.D.R., and Fontana, R. “Transplantation and Acute Liver Failure”. Panminerva Medica 2003;45(2):  85-94.
  6. Higgins, P.D.R., and Rockey, D.C. “Iron Deficiency Anemia”. Techniques in Gastrointestinal Endoscopy  2003; 5: 134-141.  Review.
  7. Higgins, P.D.R., and Laine, L. “Ischemic Colitis: A Systematic Review”. Alimentary Pharmacology and Therapeutics 2004; 19(7):729-38.  Review.
  8. Higgins, P.D.R., and Johanson, J. “A Systematic Review of the Epidemiology of Constipation”. American Journal of Gastroenterology 2004; 99(4): 750-759. Review.
  9. Higgins, P.D.R., and Zimmermann, E.M. “Inflammatory Bowel Disease Diagnosis and Therapy”. Clinics in Family Practice 2004; 6(3): 671-692. Review.
  10. Higgins, P.D.R., Schwartz, M., Mapili, J., and Zimmermann, E.M. “Is Endoscopy Necessary for the Measurement of Disease Activity in Ulcerative Colitis?” American Journal of Gastroenterology 2005; 100(2):355-361.
  11. Higgins, P.D.R., Schwartz, M., Mapili, J., and Zimmermann, E.M. “Patient-Defined Dichotomous End Points for Remission and Clinical Improvement in Ulcerative Colitis”. Gut 2005; 54: 782-788.
  12. Poynter, J.N., Gruber, S.B., Higgins, P.D.R., Almog, R., Bonner, J.D., Rennert, H.S., Low, M., Greenson, J.K., and Rennert, G. Statins and the Risk of Colorectal Cancer. New England Journal of Medicine 2005; 352: 2184-2192.
  13. Higgins, P.D.R., Umar, R. Parker, J.W., and DiMagno, M. Massive Lower Gastrointestinal Bleeding after Rejection of Pancreatic Transplants. Nature Clinical Practice Gastroenterology and Hepatology, 2005; 2: 240-244.
  14. Harris, Richard E., Jeter, Joanne, Chan, Paul, Higgins, P.D.R., Kong, Feng-Ming, Fazel, Reza, Bramson, Candace, Gillespie, Brenda, and Cohort 11 of the UM CRDSA. “Using Accupressure to Modify Alertness in the Classroom: A Single-Blind, Randomized, Crossover Trial” The Journal of Alternative and Complementary Medicine. 2005; 11(4): 673-679.
  15. Demierre, Marie-France*, Higgins, P.D.R.*, Gruber, Stephen B., Hawk, Ernest, and Lippmann, Scott. Statins and Cancer Prevention, Nature Reviews Cancer, 2005; 5:  930-942. Review.
  16. Waljee, A. and Higgins, P.D.R. “Statins Reduce Inflammation, DVT, Osteoporosis, and Colon Cancer: Could they be of Benefit in IBD?” Practical Gastroenterology, 2006; 30(4): 34-46. Editorial.
  17. Waljee, A., Waljee, J., Morris, A., and Higgins, P.D.R. “Three-Fold Increased Risk of Infertility: A Meta-Analysis of Infertility after Ileal Pouch Anal Anastomosis in Ulcerative Colitis” Gut, 2006; 55: 1575-80. (3)
  18. Bhuket, T.P., and Higgins, P.D.R. “Statins and Gastrointestinal Cancer” Nature Clinical Practice Gastroenterology and Hepatology, 2006; 3(10):  552-562. Review.
  19. Menees, S., Higgins, P.D.R., Korsnes, S, Elta, G. Does Colonoscopy Preparation Cause a Flare of Ulcerative Colitis Symptoms? Inflammatory Bowel Diseases, 2007; 13(1):  12-18.
  20. Higgins, P.D.R., Caoili, E., Zimmermann, M., Bhuket, T. P., Sonda, P., Manoogian, B., Platt, J., and Zimmermann, E.M. Computed Tomographic Enterography (CTE) Adds Information to Clinical Management in Small Bowel Crohn’s Disease, Inflammatory Bowel Diseases, 2007; 13(3): 262-268.
  21. Higgins, P.D.R., Leung, J., Schwartz, M., Mapili, J., Wren, P.A., Zimmermann, E.M. The Quantitative Validation of Non-Endoscopic Disease Activity Indices in Ulcerative Colitis, Alimentary Pharmacology and Therapeutics, 2007; 25(3):333-42.
  22. Higgins, P.D.R., Katz, S., Wolf, D.C., and Present, D.H. Clinical Trial Designs in Ulcerative Colitis. Gastroenterology and Hepatology, 2007; 3(3) S10:  1-7.
  23. Bandarenko, N., and Higgins, P.D.R. Treatment of Inflammatory Bowel Disease:  An Overview of Pharmacologics, Biologics, and Selective Leukocyte Apheresis. CME Monograph. MediCine, Inc., New York, NY. June, 2007. Review.
  24. Awais, D., and Higgins, P.D.R. Should we be CHARMed?, Inflammatory Bowel Diseases, 2007 Oct;13(10):1308-9. Editorial.
  25. Elmunzer, J., Higgins, P.D.R., Kwok, Y., and Elta, G. Jumbo forceps are superior to standard large-capacity forceps in obtaining diagnostically adequate inflammatory bowel disease surveillance biopsies. Gastrointestinal Endoscopy, 2008; 68(2):273-8.
  26. Kim, K., Rangwalla, S., Congxian, J., Higgins, P.D.R., and Rubin, J. Non-Invasive Ultrasound Elasticity Imaging (UEI) On Crohn's Disease: Animal Model. Ultrasound in Medicine and Biology, 2008; 34(6):902-12. PMCID:  PMC3157329
  27. Elmunzer, B.J., Waljee, A.K., Elta, G.H., Taylor, J.R., Fehmi, S.M.A., Higgins, P.D.R. A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis. Gut, 2008; 57(9):1262-7.
  28. Bruce E. Sands, William J. Sandborn, Brian Feagan, Robert Löfberg, Toshifumi Hibi, Tao Wang, Lisa–Marie Gustofson, Cindy J. Wong, Margaret K. Vandervoort, Stephen Hanauer, and the Adacolumn Study Group. A Randomized, Double-Blind, Sham-Controlled Study of Granulocyte/Monocyte Apheresis for Active Ulcerative Colitis. Gastroenterology, 2008; 135: 400-409 [P. Higgins – I participated in this study as a site PI, and I am cited in the publication].
  29. Stenson, W.F., Snapper, Scott B., and the CCFA Research Challenges Work Groups. Challenges in IBD Research: Assessing Progress and Rethinking the Research Agenda. Inflammatory Bowel Diseases, 2008; 14: 687-708 [P. Higgins – I co-chaired the Clinical Research Working Group with Bruce Sands].
  30. Spiegel, B.M.R., Ho, W., Esrailian, E., Targan, S., Higgins, P.D.R., Siegel, C., Dubinsky, M., Melmed, G. Controversies in Ulcerative Colitis: A National Survey Comparing Decision-Making of Experts versus Community Gastroenterologists. Clinical Gastroenterology and Hepatology, 2008, 7: 168-174.
  31. Joyce, J.C., Waljee, A.K., Khan, T.A., Wren, P.A., Dave, M., Zimmermann, E.M., Wang, S., Zhu, J., Higgins, P.D.R. Identification of Symptom Domains in Ulcerative Colitis that Occur Frequently During Flares and are Responsive to Changes in Disease Activity. Health and Quality of Life Outcomes 2008, 6:69. PMCID:  PMC2559827
  32. Irvine, E.J., Yeh, C-H, Ramsey, D., Stirling, A.L., Higgins, P.D.R. The effect of mesalamine therapy on quality of life in patients with mildly to moderately active ulcerative colitis. Alimentary Pharmacology and Therapeutics. 2008, 28: 1278-86. 
  33. Rangwalla, S.R., Waljee, A.K., Higgins, P.D.R. The Voting With their Feet (VWF) Endpoint: A Meta-Analysis of an Alternative Endpoint in Clinical Trials, Using 5-ASA Induction Studies in Ulcerative Colitis. Inflammatory Bowel Diseases, 2009, 15(3): 422-8.
  34. Higgins, P.D.R., Rubin, D.T., Kaulback, K., Schoenfeld, P.S., Kane, S.V. Systematic Review: Impact of Non-Adherence to 5-ASA Products on the Frequency and Cost of Ulcerative Colitis Flares. Alimentary Pharmacology and Therapeutics. 2009, 29: 247-57. Review.
  35. Kane, S., Lu, F., Kornbluth, A., Awais. D., Higgins, P.D.R. Controversies in mucosal healing in ulcerative colitis. Inflammatory Bowel Diseases, 2009, 15: 796-800. Editorial.
  36. Waljee, A.K., Joyce, J.C., Wren, P.A., Khan, T.M., Higgins, P.D.R. Patient reported symptoms during an ulcerative colitis flare:  A Qualitative Focus Group Study. European Journal of Gastroenterology & Hepatology. 2009, 21: 558-64. PMCID:  PMC3193174
  37. Singal A, Volk ML, Waljee A, Salgia R, Higgins P.D.R., Rogers MA, Marrero JA. Meta-Analysis: Surveillance with Ultrasound for Early Stage Hepatocellular Carcinoma in Patients with Cirrhosis. Alimentary Pharmacology and Therapeutics. 2009, 30: 37-47.
  38. Rubenstein, J.H., Waljee, A.K., Jeter, J., Velayos, F., Ladabaum, U., Higgins, P.D.R. Cost-Effectiveness of Ulcerative Colitis Surveillance in the Setting of 5-Aminosalicylates. American Journal of Gastroenterology, 2009, 104:  2222-2232. PMCID: PMC2764368
  39. Adler, J., Stidham, R.J., Higgins, P.D.R. Bringing the Inflamed and Fibrotic Bowel into Focus: Imaging in Inflammatory Bowel Disease. Gastroenterology and Hepatology, 2009; 5: 1-11. Review. PMCID: PMC2886363
  40. Awais, D., Seigel, C.A., Higgins, P.D.R., Modeling Dysplasia Detection in Ulcerative Colitis: Clinical Implications of Surveillance Intensity. Gut. 2009, 58: 1498-1503.
  41. Luther, J., Higgins, P.D.R., Schoenfeld, P., Moayyedi, P., Vakil, N., Chey, W. Empiric Quadruple vs. Triple Therapy for Primary Treatment of Helicobacter pylori Infection: Systematic Review and Meta-Analysis of Efficacy and Tolerability. American Journal of Gastroenterology, 2010, 105: 65-73.
  42. Waljee, A.K., Joyce, J.C., Wang, S., Saxena, A., Hart, M., Zhu, J., Higgins, P.D.R. Machine Learning Outperforms Metabolites in Identifying Responders to Thiopurines in Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology, 2010; 8: 143-150.
  43. Luther, J., Dave, M., Higgins, P.D.R., Kao, J.Y. Association between Helicobacter pylori Infection and Inflammatory Bowel Disease: A Meta-analysis and Systematic Review of the Literature. Inflammatory Bowel Diseases, 2010, 16: 1077-84.
  44. Stidham, R.J., Waljee, A.K., Higgins, P.D.R. Evolving Endpoints in IBD Management. IBD Monitor, 2010, 4: 285-291. Review.
  45. Adler, J, Higgins PDR. Getting the Steak without the Sizzle: Is MR enterography as good as CT Enterography? Inflammatory Bowel Diseases, 2010, 16: 712-713. Review.
  46. Dave, M., Elmunzer, B.J., Dwamena, B.A., Higgins, P.D.R. Primary Sclerosing Cholangitis: A meta-analysis of diagnostic performance of Magnetic Resonance Cholangiopancreatography. Radiology, 2010, 256: 387-396.
  47. Huang, E.H., Johnson, L.A., Eaton, K., Hynes, M.J., Carpentino, J.E., Higgins, P.D.R. Atorvastatin Induces Apoptosis in vitro And Slows Growth Of Tumor Xenografts But Not Polyp Formation In Min Mice. Digestive Diseases and Sciences, 2010, 55:3086-94.
  48. Higgins, P.D.R., Book Review: The Changing World of Inflammatory Bowel Disease, Gastroenterology, 2010, 139: 695. Review.
  49. Stidham, R.W., Higgins, P.D.R. The Value of Mucosal Assessment and Biomarkers in Inflammatory Bowel Disease. Expert Review of Gastroenterology & Hepatology, 2010; 4(3):285-91. Review.
  50. Waljee, A.K., Higgins, P.D.R. Machine Learning in Medicine: A primer for physicians. American Journal of Gastroenterology, 2010; 105(6):1224-6. Editorial.
  51. Govani, S., Higgins, P.D.R., Combination of Thiopurines and Allopurinol: Adverse Events and Clinical Benefit in IBD. Journal of Crohn’s and Colitis, 2010, 4: 444-9. PMCID: PMC3157326
  52. Higgins, P.D.R. New Keys to Maintenance Treatment in Ulcerative Colitis. Digestive Diseases, 2010, 28(3):483-9. Review. PMCID:  PMC2980819
  53. Dave, M., Johnson, L.A., Walk, S., Young, V.B., Stidham, R.W., Chaudhary, M.N., FunNell, J., Higgins, P.D.R. A Randomized Trial of Sheathed vs. Standard Forceps for Obtaining Uncontaminated Biopsy Specimens of Microbiota from the Terminal Ileum. Gut, 2011, 60: 1043-9.
  54. D'Haens GR, Panaccione R, Higgins, P.D.R, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, Löfberg R, Quary A, Sands B, Sood A, Watermayer G, Lashner B, Lémann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response? American Journal of Gastroenterology, 2011, 106: 199-212. Practice Guideline.
  55. Waljee AK, Morris AM, Waljee JF, Higgins, P.D.R. Perceived and actual quality of life with ulcerative colitis: a comparison of medically and surgically treated patients. American Journal of Gastroenterology, 2011, 106:794-799.
  56. Pausawasdi, N., Al-Hawary, M., Higgins, P.D.R. Therapeutic High-Density Barium Enema in a Case of Presumed Diverticular Hemorrhage. Case Reports in Gastroenterology 2011; 5: 88-94.
  57. Waljee, A.K., Morris, A.M., Waljee, J.F., Higgins, P.D.R., Individual Health Discount Rate in Patients with Ulcerative Colitis. Inflammatory Bowel Diseases, 2011, 17: 1328-32.
  58. Adler, J, Rangwalla, SC, Dwamena, BA, Higgins, P.D.R. The Prognostic Power of the NOD2 Genotype for Compicated Crohn’s Disease: A Meta-Analysis. American Journal of Gastroenterology, 2011, 106: 699-712.
  59. Adler J, Swanson SD, Schmiedlin-Ren P, Higgins P.D.R, Golembeski CP, Polydorides AD, McKenna BJ, Hussain HK, Verrot TM, Zimmermann EM. Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn’s Disease. Radiology, 2011, 259:127-135. PMCID:  PMC3064818
  60. Higgins, P.D.R, Johnson LA, Sauder K, Moons D, Blanco L, Taube S, Wobus, CE. Transient or Persistent Norovirus Infection Does not Alter the Pathology of Salmonella typhimurium induced intestinal inflammation and fibrosis in mice.  Comp Immunol Microbiol Infect Dis, 2011, 34: 247-257. PMCID:  PMC3167145
  61. Higgins, P.D.R, Johnson, L.A., Luther, J., Zhang, M., Sauder, K.L., Blanco, L.P., Kao, J.Y., Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine. Inflammatory Bowel Diseases. 2011; 17: 1398-1408.
  62. Higgins, P.D.R. Who Wants to Take a Thiopurine Holiday? American Journal of Gastroenterology, 2011, 106: 556-558. Editorial.
  63. Travis SP, Higgins P.D.R., Orchard T, Van Der Woude CJ, Panaccione R, Bitton A, O'Morain C, Panés J, Sturm A, Reinisch W, Kamm MA, D'Haens G. Review article: defining remission in ulcerative colitis. Alimentary Pharmacology and Therapeutics. 2011 34: 113-24. Review.
  64. Stidham, R.W., Xu, J., Johnson, L.A., Kim, K., Moons, D.S., McKenna, B., Rubin, J.M., Higgins, P.D.R. Ultrasound Elasticity Imaging for Detecting Intestinal Fibrosis and Inflammation in Rats and Humans with Crohn’s Disease. Gastroenterology, 2011, 141(3):819-826.
  65. Brown, L.K., Waljee, A.K., Higgins, P.D.R., Waljee, J.F., Morris, A.M. Proximity to disease and perception of utility: Physicians’ vs. patients’ assessment of treatment options for ulcerative colitis. Diseases of the Colon and Rectum. 2011, 54: 1529-36.
  66. Johnson, L.A., Govani, S.M., Joyce, J.C., Waljee, A.K., Gillespie, B.W., Higgins, P.D.R., Spironolactone and colitis: Increased mortality in rodents and humans.  Inflammatory Bowel Diseases, 2012, 18: 1315-1324. PMCID:  PMC3288762
  67. Johnson, L.A., Luke, A., Sauder, K., Moons, D.S., Horowitz, J.C., Higgins, P.D.R. Intestinal Fibrosis is Reduced by Early Elimination in a Mouse Model of IBD: Impact of a “Top-Down” Approach to Intestinal Fibrosis in Mice. Inflammatory Bowel Diseases, 2012, 18:460-71. PMCID:  PMC3206985
  68. Horowitz, JC, Ajayi, IO, Kulasekaran, P, Rogers, DS, White, JB, Townsend, SK, White, ES, Nho RS, Higgins, P.D.R., Huang, SK, Sisson, TH. Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. Int J Biochem Cell Biol., 2012, 44:158-169. PMCID:  PMC3241828
  69. Xu, J., Tripathy, S., Rubin, J.M., Stidham, R.W., Johnson, L.A., Higgins, P.D.R., and Kim, K. A New Nonlinear Parameter in the Developed Strain-To-Applied Strain of the Soft Tissues and Its Application in Ultrasound Elasticity Imaging. Ultrasound in Medicine and Biology, 2012; 38: 511-23. PMCID:  PMC3241828
  70. Elmunzer, B.J., Scheiman, J.M, Lehman, G.A., Chak, A., Mosler, P., Higgins, P.D.R., Hayward, R.A., Romagnuolo, J., Elta, G.H., Sherman, S., Waljee, A.K., Repaka, A., Atkinson, M., Cote, G.A., Kwon, R.S., McHenry, L., Piraka, C., Wamsteker, E.J., Watkins, J.L., Korsnes, S.J., Schmidt. S.E., Turner, S.M., Nicholson, S., Fogel, E.L.  on behalf of the United States Cooperative for Outcomes Research in Endoscopy (USCORE). A Randomized Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis. New England Journal of Medicine, 2012; 366: 1414-22. PMCID:  PMC3339271
  71. Govani, S.M., Higgins, P.D.R. How to Read a Clinical Trial Paper: A Lesson in Basic Trial Statistics. Gastroenterology & Hepatology, 2012; 8: 241-248. PMCID:  PMC3380258
  72. Katz, L, Gisbert, JP, Manoogian, B, Lin, K, Steenholdt, C, Mantzaris, GJ, Atreja, A., Ron, Y, Swaminath, A, Shah, S, Hart, A, Lakatos, PL, Ellul P, Israeli, E, Svendsen, MN, van der Woude, CJ, Katsanos, KH, Yun, L, Tsianos, EV, Nathan, T, Abreu, M, Dotan, I, Lashner, B, Brynskov, J, Terdiman, JP, Higgins, P.D.R., Chaparro, M, Ben-Horin, S.  Doubling the infliximab dose versus halving the infusion intervals in Crohn's disease patients with loss of response. Inflammatory Bowel Diseases, 2012, 18: 2026-33.
  73. Reider, F., Karrasch, T. Ben-Horin, S., Schirebel, A., Ehehalt, R., Wehkamp, J., de Haar, C., Velin, D., Latella, G., Scaldaferri, F., Rogler, G., Higgins, P.D.R., Sans, M. Results of the 2nd Scientific Workshop of the ECCO: Basic Mechanisms of Intestinal Healing. Journal of Crohn’s and Colitis, 2012; 6: 373-385.
  74. Peyrin-Biroulet, L.,  Billoud, V., D’Haens, G., Panaccione, R., Feagan, B., Panes, J., Danese, S., Schreiber, S., Ogata, H., Hibi, T., Higgins, P.D.R., Beaugerie, L., Chowers, Y., Louis, E., Steinwurz, F., Reinisch, W., Rutgeerts, P., Colombel, J.F., Travis, S., Sandborn, W.J. Development of the Paris Definition of Early Crohn’s Disease for Disease-Modification Trials: Results of an International Expert Opinion Process. American Journal of Gastroenterology, 2012, 107: 1770-6.
  75. Johnson, L.A., Sauder, K.L., Rodansky, E.S., Simpson, R.U., Higgins, P.D.R., CARD-024, A Vitamin D Analog, Attenuates the Pro-fibrotic Response to Substrate Stiffness in Colonic Myofibroblasts. Experimental and Molecular Pathology, 2012; 93: 91-98.
  76. Saini, SD, Waljee, AK, Higgins, P.D.R. Cost-Utility of Inflammation-Targeted Therapy In Ulcerative Colitis. Clinical Gastroenterology and Hepatology, 2012, 10: 1143-51.
  77. Stidham, RW, Sauder, K, Higgins, P.D.R.  Using Bibliometrics to Advance Your Academic Career. Gastroenterology, 2012, 143: 520-3.
  78. Dave, Maneesh, Higgins, P.D.R. , Rioux, Kevin. The Human Gut Microbiome: Current Knowledge, Challenges, and Future Directions. Translational Research, 2012, 150: 246-257.
  79. Hueber, W., Sands, B.E., Lewitzky, S., Vandemeulebroecke, M., Reinisch, W., Higgins, P.D.R. , Wehkamp, J., Feagan, B.G., Yao, M.D., Karczewski, M., Karczewski, J., Pezous, N., Bek, S., Bruin, G., Mellgard, B., Berger, C., Londei, M., Bertolino, A.P., Tougas, G., Travis, S.P.L. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut, 2012, 61:1693-1700.
  80. Ajayi, I.O., Sisson, T.H., Higgins, P.D.R., Booth, A.J., Sagana, R.L., Maher, T., Huang, S.K., White, E.S., King, J.E., Moore, B.M., Horowitz, J.C. Increased Survivin Expression Contributes to Apoptosis-resistance in IPF Fibroblasts. Advances in Bioscience and Biotechnology, 2012, 3: 657-664.
  81. Johnson, L.A., Rodansky, E., Sauder, K., Horowitz, J.C., Mih, J., Tschumperlin, D.A. Higgins, P.D.R., Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts. Inflammatory Bowel Diseases, 2013, 19: 891-903.
  82. Elmunzer, B.J., Higgins, P.D.R., Saini, S.D, Scheiman, J.M., Parker, R.A., Chak, A., Romagnuolo, J., Mosler, P., Hayward, R.A., Elta, G.H., Korsnes, S. J., Schmidt, S.E., Sherman, S., Lehman, G.A., Fogel, E.L. Does Rectal Indomethacin Eliminate the Need for Prophylactic Pancreatic Stent Placement in Patients Undergoing High-Risk ERCP? Post hoc Efficacy and Cost-Benefit Analyses Using Prospective Clinical Trial Data. American Journal of Gastroenterology, 2013, 108: 410-415.
  83. Dillman, J.R., Stidham, R.W.,  Higgins, P.D.R. , Moons, D.S., Johnson, L.A., Rubin, J.M. Ultrasound Elastography-Derived Shear Wave Velocity Elastography Helps Distinguish Acutely Inflamed from Fibrotic Bowel in a Crohn Disease Animal Model. Radiology, 267(3), 767-766, 2013.
  84. Denson, L.A., Long, M.D., McGovern, D.P.B., Kugathasan, S., Wu, G.D., Young, V.B., Pizarro, T.T., de Zoeten, E.F., Stappenbeck, T.S., Plevy, S.E., Abraham, C., Nusrat, A., Jobin, C., McCole, D.F., Siegel, C.A., Higgins, P.D.R., Herfarth, H.H., Hyams, J., Sandborn, W.J., Loftus, E.V.,  Kappelman, M.D.,  Lewis, J.D.,  Parkos, C.A.,  Sartor, R.B., Challenges in IBD Research: Update on Progress and Prioritization of the CCFA’s Research Agenda. Inflamm Bowel Dis, 2013, 19: 677-82.
  85. Govani, S.M., Stidham, R.W., Higgins, P.D.R. How Early to Take Arms Against a Sea of Troubles? The Case for Aggressive Early Therapy in Crohn’s Disease to Prevent Fibrotic Intestinal Strictures. Journal of Crohn’s and Colitis, 2013, 7: 923-7.
  86. Sands, B.E., Katz, S., Wolf, D.C., Feagan, B.G., Wang, T., Gustofson, L.M., Wong, C.J., Vandervoort, M.K., Hanauer, S. and the Adacolumn Study Group. A Randomized, Double-Blind, Sham-Controlled Study of Granulocyte/Monocyte Apheresis for Moderate to Severe Crohn’s Disease. Gut, 2013; 62: 1288-1294. [P.D.R. Higgins – I participated in this study as a site PI, and I am cited in the publication].
  87. Waljee, A.K., Mukherjee, A., Singal, A.G., Zhang, Y., Warren, J., Balis, U., Marrero, J., Zhu, J., Higgins, P.D.R. Comparison of Modern Imputation Methods for Missing Laboratory Data in Medicine. BMJOpen, 2013, 3: e002847.
  88. Faubion, W.A., Fletcher, J.G., O’Byrne, S., Feagan, B., Devilliers, W., Salzberg, B.A., Plevy, S., Proctor, D., Valentine, J., Higgins, P.D.R., Tew, W., Keir, M. Emerging Biomarkers for Crohn’s Disease Activity – Role of Cross-Sectional Imaging. American Journal of Gastroenterology, 2013, 108: 1891-900.
  89. Singal, A.G., Mukherjee, A., Elmunzer, B.J., Higgins, P.D.R., Lok, A.S., Zhu, J., Marrero, J.A., Waljee, A.K. Machine Learning Algorithms Outperform Conventional Regression Models in Predicting Development of Hepatocellular Carcinoma. American Journal of Gastroenterology, 2013, 108: 1723-30.
  90. Govani, S.M., Waljee, A.K., Higgins, P.D.R. Anti-adhesion therapies and the Rule of 3 for Rare Events.  American Journal of Gastroenterology, 2013, 108: 1831-2.
  91. Singal, A.G., Higgins, P.D.R., Waljee, A.K. A Primer on Effectiveness and Efficacy Trials. Clin Transl Gastroenterol. 2014, 5: e45.
  92. Magro, F., Peyrin-Biroulet, L., Sokol, H., Aldeger, X., Costa, A., Higgins, P.D.R., Joyce, J.C., Kastanos, K.H., Lopez, A., Mas de Xaxars, T., Toader, E., Beaugerie, L. Extraintestinal malignancies in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (III). Journal of Crohn’s and Colitis, 2014, 8: 31-44.
  93. Waljee, A.K., Higgins, P.D.R., Singal, A.G. A Primer on Predictive Models. Clin Transl Gastroenterol. 2014, 5: e45.
  94. Johnson, L.A., Rodansky, E.S., Haak, A.J., Larsen, S.D., Neubig, R.R., Higgins P.D.R. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-beta induced fibrogenesis in human colonic myofibroblasts. Inflammatory Bowel Diseases 2014, 20: 154-65.
  95. Waljee, A.K., Stidham, R., Higgins, P.D.R., Vijan, S., Saini, S.D. Point-Counterpoint: Are we Overtreating Patients with Mild Ulcerative Colitis? Journal of Crohn’s and Colitis, 2014, 8: 80-4.
  96. Stidham, R.W., Lee, T.C., Higgins, P.D.R., Deshpande, A.R., Sussman, D.A., Singal, A.G., Elmunzer, B.J., Saini, S.D., Vijan, S., Waljee, A.K. Systematic Review with Network Meta-Analysis: The Efficacy of Anti-Tumour Necrosis Factor-Alpha Agents for the Treatment of Ulcerative Colitis. Alimentary Pharmacology and Therapeutics. 2014, 39: 660-71.
  97. Vavricka, S.R., Rogler, G., Maetzler, S., Misselwitz, B., Safroneeva, E., Frei, P., Manser, C.N., Biedermann, L., Fried, M., Higgins, P.D.R., Wojtal, K.A., Schoepfer, A.M. High Altitude Journeys and Flights are Associated with An Increased Risk for Flares in Inflammatory Bowel Disease Patients. Journal of Crohn’s and Colitis, 2014, 8: 191-9.
  98. Stidham, R.W., Lee, T.C., Higgins, P.D.R., Deshpande, A.R., Sussman, D.A., Singal, A.G., Elmunzer, B.J., Saini, S.D., Vijan, S., Waljee, A.K. Systematic Review with Network Meta-Analysis: The Efficacy of Anti-Tumour Necrosis Factor-Alpha Agents for the Treatment of Crohn’s Disease. Alimentary Pharmacology and Therapeutics. 2014, 39(12), 1349-62.
  99. Dillman, J.R., Johnson, L.A., Rubin, J., Moons, D., Stidham, R.W., Higgins, P.D.R., Ultrasound Shear Wave Elastography Helps Discriminate Low-Grade from High-Grade Bowel Wall Fibrosis in Ex Vivo Human Intestinal Specimens. Ultrasound in Medicine and Biology, 2014, 33: 2115-2123.
  100. Govani, S.M., Guentner, A.S., Waljee, A.K., Higgins, P.D.R., Risk Stratification of Emergency Department Patients with Crohn’s Disease Could Reduce Computed Tomography Use by Nearly Half. Clinical Gastroenterology and Hepatology, 2014, 12: 1702-1707.
  101. Rieder, F., deBruyn, J.R., Pham, B.T., Katsonos, K., Annese, V., Higgins, P.D.R., Magro, F., Dotan, I. Results of the 4th Scientific Workshop of the ECCO (Group II): Markers of Intestinal Fibrosis in Inflammatory Bowel Disease. Journal of Crohn’s and Colitis, 2014, 8: 1166-1178.
  102. Factors Associated with Poor Outcomes in Adults with Newly Diagnosed Ulcerative Colitis. Reinisch, W., Renink, A.R., Higgins, P.D.R., Clinical Gastroenterology and Hepatology, 2015, 13: 635-642.
  103. Higgins, P.D.R., Skup, M., Mulani, P.M., Lin, J., Chao, J. Increased Risk of Venous Thromboembolic Events with Corticosteroids Versus Biologic Use in Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology, 2014, 13: 316-21.
  104. Govani, S.M., Waljee, A.K, Higgins, P.D.R. Response to Feagan, et al. American Journal of Gastroenterology, 2014, 109: 1084-5.
  105. Sands, B.E., Feagan, B.G., Rutgeerts, P., Colombel, J.-F., Sandborn, W.J., Sy, R., D’Haens, G., Ben-Horin, S., Zu, j., Rosario, M., Fox, I., Parikh, A., Milch, C., Hanauer, S. Effects of Vedolizumab Induction Therapy for Patients with Crohn’s Disease in Whom Tumor Necrosis Factor Antagonist Treatment Failed. Gastroenterology, 2014, 147: 618-27. [P.D.R. Higgins – I participated in this study as a site PI, and enrolled 15 subjects].
  106. Higgins, P.D.R. The IBD Drug Pipeline – Ready to Deliver? American Journal of Gastroenterology, 2014, 109: 1052-54.
  107. Dillman, J.R., Swanson, S.D., Johnson, L.A., Moons, D.S., Adler, J., Stidham, R.W., Higgins, P.D.R. Comparison of Noncontrast MRI Magnetization Transfer and T2-Weighted Signal Intensity Ratios for Detection of Bowel Wall Fibrosis in a Crohn’s Disease Animal model. J Mag Res Imaging. 2015; 42: 801-810.
  108. Choksi, N, Fogel, EL, Cote, GA, Romagnuolo, J, Elta, GH, Scheiman, JM, Chak, A, Mosler, P, Higgins, PDR, Korsnes, SJ, Schmidt, SE, Sherman, S, Lehman, GA, Elmunzer, BJ. The risk of post-ERCP pancreatitis and the protective effect of rectal indomethacin in cases of attempted but unsuccessful prophylactic pancreatic stent placement. Gastrointestinal Endoscopy 2015; 81: 151-155.
  109. Govani, SM, Higgins, PDR, Stidham, RW, Montain, SJ, Waljee, AK. Increased Ultraviolet Light Exposure is Associated With Reduced Risk of Inpatient Surgery Among Patients With Crohn’s Disease. Journal of Crohn's and Colitis 2015; 9, 77-81.
  110. Herfarth, H.H., Rogler, G., Higgins, P.D.R. Pushing the Pedal to the Metal: Should We Accelerate Infliximab Therapy for Patients with Severe Ulcerative Colitis? Clin Gast Hepatol. 2015, 13: 335-338.
  111. Higgins, PDR, Fletcher, JG. Characterization of Inflammation and Fibrosis in Crohn’s Disease Lesions by Magnetic Resonance Imaging. The American journal of Gastroenterology 2015; 110: 441-443.
  112. Goldsmith, JR, Higgins, PDR. The Current State of the Inflammatory Bowel Disease Drug Pipeline: A Promising Time. Practical Gastroenterology 2015; 20-27.
  113. Xu, G, Johnson, LA, Hu, J, Dillman, JR, Higgins PDR, Wang, X.  Detecting Inflammation and Fibrosis in Bowel Wall with Photoacoustic Imaging in a Crohn’s disease animal model. SPIE BiOS 2105, 932347-932347-5.
  114. Rao, K, Micic, D, Natarajan, M, Winters, S, Kiel, MJ, Walk, ST, Santhosh, K, Mogle, JA, Galecki, AT, LeBar, W, Higgins, PDR, Young, VB, Aronoff, DM. Clostridium difficile Ribotype 027: Relationship to Age, Detectability of Toxins A or B in Stool With Rapid Testing, Severe Infection, and Mortality 2015; 15:233-41.
  115. Govani, SM, Waljee, AK, Stidham, RW, Higgins, PDR. Increasing ultraviolet light exposure is associated with reduced mortality from Clostridium difficile infection. United European Gastroenterology Journal. 2015; 3: 2018-214.
  116. Reinisch, W., Renink, A.R., Higgins, P.D.R., Factors Associated with Poor Outcomes in Adults with Newly Diagnosed Ulcerative Colitis. Clinical Gastroenterology and Hepatology, 2015, 13: 635-642.