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Richard A. Miller, M.D., Ph.D.

Title and department:
Professor of Pathology
Associate Director for Research, Geriatrics Center
Research Professor, Institute of Gerontology

Mailing address:
University of Michigan
Biomedical Sciences Research Building
Room 3001
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Lab address:
3188 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Phone: (734) 936-2122; Fax: (734) 647-9749

E-mail: millerr@umich.edu

Links to laboratory or personal web pages:
http://www-personal.umich.edu/~millerr/RAM_home_page.htm

Research Interests
Miller's research work centers on problems in the genetics and cell biology of aging in mice. Special interests include:

• analysis of genes and diets that increase life span in mice

• studies of treatments that repair immune function in old age

• relationship of cell stress resistance to extended life span in dwarf mice

• biomarkers of aging rate
   
Brief Biography
Richard A. Miller, M.D., Ph.D., is a professor of Pathology and associate director for research of the Geriatrics Center at the University of Michigan. He received a B.A. degree in 1971 from Haverford College, and M.D. and Ph.D. degrees from Yale University in 1976-1977.  After postdoctoral studies at Harvard and Sloan-Kettering, he moved to Boston University in 1982 and then to his current position at Michigan in 1990.  Dr. Miller has served in a variety of editorial and advisory positions on behalf of the American Federation for Aging Research and the National Institute on Aging, and as an editor-in-chief of Aging Cell.  He is the recipient of the Nathan Shock Award, the AlliedSignal Award, the Irving Wright Award and the Kleemeier Award for aging research. His main research interests all relate to the control of aging rate in mice, and include ongoing studies of mutations that slow aging, the relation of cellular stress resistance to longevity, mapping of genes that influence lifespan and age-sensitive traits, screens for drugs that extend lifespan in mice, and methods to improve function of T lymphocytes from old donors.

Recent Publications
Miller, R. A.  2002.  Extending life: scientific prospects and political obstacles.  Milbank Quarterly 80:155 – 174.   

Harper, J. M., A. B. Salmon, S. F. Leiser, A. T. Galecki, and R. A. Miller.  2007.  Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone.  Aging Cell 6:1-13. 

Miller, R. A.  2009.  Cell stress and aging: new emphasis on multiplex resistance mechanisms.  J Gerontol A Biol Sci Med Sci. 64:179-82. 

Harrison, D. E., R. Strong, Z. D. Sharp, J. F. Nelson, C. M. Astle, K. Flurkey, N. L. Nadon, J. E. Wilkinson, K. Frenkel, C. S. Carter, M. Pahor, M. Javors, E. Fernandez, and R. A. Miller.  2009.  Rapamycin fed from 20 months of age extends lifespan in genetically heterogeneous mice.  Nature 460: 392 - 395.

Leiser, S. F., and R. A. Miller.  2010.  Nrf2 Signaling: a mechanism for cellular stress resistance in long-lived mice.  Molecular and Cellular Biology 30:871-884.