Studies Seeking Healthy Subjects
"Tissue-Specific Metabolic Reprogramming in Diabetic Complications. Glycemic Clamp Studies to Determine the Real Time Synthesis Rates of Glucose Derived Metabolites in Individuals With Type 1 Diabetes and Healthy Controls"
IRB Number: HUM00060967
Principal Investigator: Dr. Rodica Pop-Busui
Purpose: To assess steady state and dynamic metabolite changes in subjects with type 1 diabetes with and without microvascular complications and to understand differences from non-diabetics in metabolite levels and flux.
The hypothesis is that diabetic complications arise from tissue-specific metabolic reprogramming resulting in alterations in fuel utilization that lead to dysfunction of the tissue. To test this hypothesis, we will use sensitive and specific mass-spectrometer-based metabolomic analysis to measure steady-state metabolite levels in plasma and urine from controls subjects and subjects with T1DM, without and with diabetic complications, during euglycemic and hyperglycemic clamp studies.
Group 1: T1DM subjects without complications
Subjects may not:
Compensation: $350 for successful completion of the study.
"Identification of phenotypic factors that predict success for weight loss and long-term weight maintenance"
Principal Investigator: Dr. Amy Rothberg
Study Description: We are looking for lean, healthy people ONLY. BMI no greater than 25 kg/m2, 30-70 years old who have little to light physical activity. You will be asked to participate in a study which could include: a treadmill test to determine your exercise capacity; a test to determine your body's preference for fat or carbohydrate use as a fuel; a blood draw to measure hormones, metabolites and genes related to metabolism; a psychological test to assess your mood and attitudes to food; an interview to recall food consumption; an x-ray test to look at your body composition; muscle and fat biopsies to measure molecules that may contribute to body weight.
* Age Range: From 30 to 70 years
Location of Study Visits: Ann Arbor, MI
"Type 1 Diabetes TrialNet Natural History Studies"
Principal Investigator: Dr. Massimo T. Pietropaolo
Other eligibility factors:
Compensation: None (over 10,000 people are being recruited for the study)
For general questions about our clinical studies, send email to email@example.com