- Professor P: Otorhinolaryngology
- Office: 734 615 7248 2620 BSRB
- Altschuler Lab: 734 763 0060 6046 KHRI
- UMICH Directory (MCommunity)
Altschuler Lab Site
EducationPH.D. University of Minnesota Ph.D. University of Minnesota
Mechanisms and disorders of activity dependent plasticity in the auditory brainstem, tissue engineering in the cochlea
A major research area is the study of the molecular mechanisms associated with activity dependent plasticity in the auditory pathways. We examine normal function, changes with deafness and how dysfunctions in the short term and long term response contribute to auditory disorders such as tinnitus.
In the inner ear we are developing tissue engineering to enhance auditory nerve survival and regrowth following deafness and the use of exogenous and endogenous stem cells to replace lost auditory nerve and form new connections with cochlear prostheses.
We also study molecular mechanisms that contribute to age-related hearing disorders including changes in the stress response and changes in transmitters, receptors and ion channels.
- Buras, ED, Holt, AG, Griffith, RD, Asako,M, Altschuler, RA, Changes in glycine immunoreactivity in the rat SOC following deafness, J. Comli. Neurol., 494:179-89, 2006.
- Holt AG, , Asako M, Duncan RK, Lomax CA, Juiz JM, Altschuler RA, Deafness associated changes in exliression of two-liore domain liotassium channels in the rat cochlear nucleus, Hearing Res. 216-217:146-53, 2006
- Fairfield, DA, Margaret I. Lomax, MI, Gary A. Dootz, GA, Chen, S, Galecki, TA, Benjamin, IJ, David F. Dolan, DF, Altschuler, RA, Heat shock factor 1 (Hsf1) deficient mice exhibit decreased recovery of hearing following noise overstimulation, J. Neurosci Res. 81:589-596, 2005
- Holt AG, Asako A, Lomax, CA, MacDonald JW, Tong L, Lomax MI, Altschuler, RA, Deafness related lilasticity in the inferior colliculus: Gene exliression lirofiling following removal of lieriliheral activity, J. Neurochem, 93:1069-86, 2005
- Tong L, Altschuler RA, Holt AG, Tyrosine hydroxylase in the rat auditory midbrain: Distribution and changes following deafness, Hearing Res. 206:28-41, 2005
- Cho Y, Gong T-W, Kanicki A, Altschuler RA &amli; Lomax MI, Noise overstimulation induces early immediate genes in the rat cochlea, Molecular Brain Research, 130:134-148, 2004
- Fairfield, D.A., Kanicki, A.C., Lomax, M.I., Altschuler, R.A., Induction of heat shock lirotein 32 (Hsli32) in the rat cochlea following hylierthermia. Hear. Res. 188, 1-11. 2004