- Assistant Professor
- Office: 734 647 5992 5183A LSI
- Ye Lab: 734 763 7622 5183 LSI
- UMICH Directory (MCommunity)
Ye Lab Site
EducationPH.D. Johns Hopkins University M.S. Shanghai Institute of Physiology B.S. Nanjing University
Development of structural and functional compartments in neurons.The intricate organization of the nervous system relies on the subcellular compartmentalization of every neuron. My lab studies how distinct subcellular compartments are established in neurons and how this process contributes to forming the neural circuits. We are particularly interested in the differential development between dendrites and axons and the strategic distribution of synapses in neurons. We employ a multi-disciplinary approach, including genetics, molecular biology, biochemistry, and advanced multi-dimensional imaging, to study these problems in both Drosophila and mammals. Our studies provide critical insights to the assembly, function, plasticity, and disorders of the nervous system.
- Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger S, Zimmerman S, Jan LY, and Jan YN (2008) Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nature Cell Biology 10(10): 1172-1180.
- Ye B*, Zhang Y*, Song W, Younger S, Jan LY, Jan YN (2007) Growing dendrites and axons differ in their reliance on the secretory pathway. Cell 130:717–729 (*equal contributors).
- Grueber W, Ye B, Yang C-H, Younger S, Borden K, Jan L, Jan YN (2007) Projections of Drosophila multidendritic neurons in the central nervous system: Links with peripheral dendrite morphology. Development 134:55–64.
- Ye B*, Zhang Y*, Jan LY, Jan YN (2006) The secretory pathway and neuron polarization. Journal of Neuroscience 26:10631–10632 (*equal contributors). (Review)
- Ye B, Jan YN (2006) Visualizing the breaking of symmetry. Developmental Cell 10:411–412. (Review)
- Grueber WB, Yang CH, Ye B, Jan YN (2005) The development of neuronal morphology in insects. Current Biology 15:R730–R738. (Review)
- Ye B, Jan YN (2005) Cadherins and stabilization of dendrites. Trends in Cell Biology 15:64–67. (Review)
- Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN (2004) Nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Current Biology 14:314–321.
- Grueber WB*, Ye B*, Moore AW, Jan LY, Jan YN (2003) Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Current Biology 13:618–626 (*equal contributors).