Administrative Core

Dean Brenner, M.D.

Diane Simeone, M.D.

The Administrative Core is responsible for leadership, guidance, and management. The Administrative Core oversees all aspects and performs numerous duties across the expansive scope of the SPORE. This core provides the framework to support the success and mission of the UMCCC SPORE as a cohesive group of investigators committed to the development of translational research in GI cancers.


Biosample Core

Thomas Giordano, M.D., Ph.D.

The overarching mission of the GI SPORE Biosample Core is to collect, catalogue and distribute human biological samples with associated pertinent clinical data to the projects to facilitate and translation research and help them accomplish their specific aims. The Biosample will be housed and administered within the Department of Pathology to ensure uncompromised patient care and confidentiality. The explicit goals of the Biosample Core include:

  • Uncompromised pathology diagnosis and patient care. Tissues will be collected with informed consent under IRB-approved protocols and patient confidentiality will be protected.
  • Prospective procurement and processing of colonic and pancreatic tissues from resection specimens. The Biosample Core with work closely with and enhance the existing Tissue Procurement Service to obtain high-quality tissue samples not needed for diagnosis.
  • Prospective collection of blood and serum from patients with colorectal and pancreatic cancer, both pre-operative and post-operative.
  • Expert pathology review of colonic and pancreatic tissues. Internationally recognized colonic and pancreatic pathologists will review all collected tissues and assist with selection of tissues for tissue array construction and interpretation of immunohistochemically-stained slides.
  • Data management. Pertinent pathologic and clinical information will be collected and managed in conjunction with GI SPORE Biostatistics and Bioinformatics Core and the Bioinformatics Group at Dartmouth Medical College.
  • Tissue array construction for validation studies. In conjunction with the UMCCC Tissue Core, the Biosample Core will construct colonic and pancreatic tissue arrays from archival pathology material.
  • Assist in tissue-based gene expression and biomarker validation studies, such as immunohistochemistry and automated in situ protein detection. Collectively, the many services of the GI SPORE Biosample Core will facilitate translational research and enhance the resources of other NCI-supported networks and groups.


Biostatistics and Informatics Core

Ananda Sen, Ph.D.

To these ends, the GI SPORE has recruited experienced biostatistical investigators who are familiar with advanced data analysis techniques, oncology and translational research, and an experienced data management team at Dartmouth Medical School, with whom the biostatisticians have considerable experience and in whom they have confidence. The biostatistical investigators keep abreast of contemporary data analysis methods in relevant fields such as machine learning and clinical trial design. Informatics personnel participate heavily in national informatics initiatives such as CaBIG.

The specific aims of the biostatistics and informatics core are:

1. To provide expertise in hypothesis formulation, experimental design, project monitoring, data analysis and development projects and cores of the GI SPORE.
2. To ensure that data collected in clinical, per-clinical and translational research is promptly, reliably and securely acquired, stored, recovered and distributed, and to support the sample management needs of translational researchers engaged in mulit-center research.

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